KR960017659A - New pyrrolidine derivatives and preparation methods thereof - Google Patents

New pyrrolidine derivatives and preparation methods thereof Download PDF

Info

Publication number
KR960017659A
KR960017659A KR1019940029176A KR19940029176A KR960017659A KR 960017659 A KR960017659 A KR 960017659A KR 1019940029176 A KR1019940029176 A KR 1019940029176A KR 19940029176 A KR19940029176 A KR 19940029176A KR 960017659 A KR960017659 A KR 960017659A
Authority
KR
South Korea
Prior art keywords
general formula
same
formula
compound
halogen
Prior art date
Application number
KR1019940029176A
Other languages
Korean (ko)
Other versions
KR100196462B1 (en
Inventor
조성민
박상후
이경주
Original Assignee
이웅열
주식회사 코오롱
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이웅열, 주식회사 코오롱 filed Critical 이웅열
Priority to KR1019940029176A priority Critical patent/KR100196462B1/en
Publication of KR960017659A publication Critical patent/KR960017659A/en
Application granted granted Critical
Publication of KR100196462B1 publication Critical patent/KR100196462B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/12—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

본 발명은 다음 일반식(Ⅰ)로 표시되는 새로운 피롤리딘 유도체 및 이를 제조하는 방법에 관한 것이다.The present invention relates to a novel pyrrolidine derivative represented by the following general formula (I) and a method for producing the same.

상기식 중에서 M는 할로겐, -OR1또는 -SR2이고 (여기서 R1, R2는 서로 같거나 다르며, 각가 수소원자 또는 탄소수 1∼3개의 저급알킬기를 나타낸다.), n은 1 또는 2의 정수이다.Wherein M is halogen, -OR 1 or -SR 2 (wherein R 1 , R 2 are the same as or different from each other, each represents a hydrogen atom or a lower alkyl group having 1 to 3 carbon atoms), and n is 1 or 2 Is an integer.

일반식(Ⅰ)로 표시된 화합물은 3번 위치의 비대칭탄소로 인환 광학이성질체를 포함한다.The compound represented by the general formula (I) includes a ring-ring optical isomer with an asymmetric carbon at position 3.

또한 본 발명은 상기 일반식(Ⅰ) 화합물의 제조방법을 제공하는 것이다.The present invention also provides a method for preparing the general formula (I) compound.

Description

새로운 피롤리딘 유도체와 그 제조방법New pyrrolidine derivatives and preparation methods thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

다음의 일반식(Ⅰ)로 표시되면 3번 위치의 비대칭탄소로 생성되는 광학 이성질체를 포함하는 새로운 피롤리딘 유도체A novel pyrrolidine derivative comprising an optical isomer produced by the asymmetric carbon at position 3, represented by the following general formula (I): 상기식 중에서 M는 할로겐, -OR1또는 -SR2이고 (여기서 R1, R2는 서로 같거나 다르며, 각가 수소원자 또는 탄소수 1∼3개의 저급알킬기를 나타낸다.), n은 1 또는 2의 정수이다.Wherein M is halogen, -OR 1 or -SR 2 (wherein R 1 , R 2 are the same as or different from each other, each represents a hydrogen atom or a lower alkyl group having 1 to 3 carbon atoms), and n is 1 or 2 Is an integer. 일반식(Ⅱ)로 표시되는 화합물을 에틸2,3-디할로프로피오네이트와 고리화 반응을 실시하여 일반식(Ⅲ)인 화합물을 만든 다음 리튬알루미늄하이드라이드를 사용하여 다음 일반식(Ⅳ)로 표시되는 알콜화합물을 제조한 후 수소반응을 통해 벤질기를 제거하여 목적화합물(Ⅰ)을 제조하는 방법.The compound represented by formula (II) was subjected to cyclization reaction with ethyl 2,3-dihalopropionate to form a compound of formula (III), followed by the following formula (IV) using lithium aluminum hydride. Method of preparing the target compound (I) by removing the benzyl group through the hydrogen reaction after preparing the alcohol compound represented by. 상기식 중에서 M는 할로겐, -OR1또는 -SR2이고 (여기서 R1, R2는 서로 같거나 다르며, 각가 수소원자 또는 탄소수 1∼3개의 저급알킬기를 나타낸다.), n은 1 또는 2의 정수이다.Wherein M is halogen, -OR 1 or -SR 2 (wherein R 1 , R 2 are the same as or different from each other, each represents a hydrogen atom or a lower alkyl group having 1 to 3 carbon atoms), and n is 1 or 2 Is an integer. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940029176A 1994-11-08 1994-11-08 Novel pyrrolidine derivatives and process for the preparations thereof KR100196462B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940029176A KR100196462B1 (en) 1994-11-08 1994-11-08 Novel pyrrolidine derivatives and process for the preparations thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940029176A KR100196462B1 (en) 1994-11-08 1994-11-08 Novel pyrrolidine derivatives and process for the preparations thereof

Publications (2)

Publication Number Publication Date
KR960017659A true KR960017659A (en) 1996-06-17
KR100196462B1 KR100196462B1 (en) 1999-06-15

Family

ID=19397348

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940029176A KR100196462B1 (en) 1994-11-08 1994-11-08 Novel pyrrolidine derivatives and process for the preparations thereof

Country Status (1)

Country Link
KR (1) KR100196462B1 (en)

Also Published As

Publication number Publication date
KR100196462B1 (en) 1999-06-15

Similar Documents

Publication Publication Date Title
KR830004201A (en) Antidepressant Derivatives of Trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
KR830004202A (en) Method for preparing cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivative as antidepressant
KR850003890A (en) Method for preparing 1H-imidazo [4,5c] -quinolin-4-amine
KR910015568A (en) Neuroprotective 3-piperidino-4-hydroxy chroman derivative
KR850004492A (en) Method for preparing an enol ether derivative of oxycam
KR850001905A (en) Method for preparing benzocyclo alkan derivatives
KR830007626A (en) Method for producing 2- (1,4-benzodioxan-2-ylalkyl) imidazole
KR900006301A (en) Method for preparing 1,4-diazabicyclo [3.2.2] nonane
KR840001152A (en) Preparation of New Heterocyclic Compounds
KR870003107A (en) Method for preparing chianthine derivative
KR960017659A (en) New pyrrolidine derivatives and preparation methods thereof
KR910009661A (en) Method for preparing N- (2-hydroxyethyl) -2-hydroxymethyl-3,4,5-trihydroxypiperidine and synthetic intermediates thereof
KR880007499A (en) Optically active 2,3-dihydro benzoxazine derivatives and preparation method thereof
KR830005122A (en) Method for producing 1-aryloxy-3-alkylamino-2-propanols
KR860003212A (en) Method for preparing 2-pyridine-thiol derivatives and acid addition salts thereof
KR910009647A (en) Method for preparing 3,4-epoxybutyrate and intermediates therefor
KR840004105A (en) Process for preparing N, N-substituted azole carboxamide derivatives
KR970027043A (en) Novel anthraquinone derivatives and preparation methods thereof
KR970001313A (en) Method for preparing formamidine derivatives
KR850004583A (en) Method for preparing phenylacetanilide derivative
KR860002454A (en) Method for preparing salicylamide derivative
KR930023357A (en) Conjugates of tocopherol-salicylic acid derivatives and preparation method thereof
KR840002848A (en) Method for preparing organophosphate
KR960000882A (en) Novel pyridone carboxylic acid derivatives and preparation method thereof
KR870011144A (en) Method for preparing cephalosporin derivative

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20031203

Year of fee payment: 6

LAPS Lapse due to unpaid annual fee