KR930023357A - Conjugates of tocopherol-salicylic acid derivatives and preparation method thereof - Google Patents
Conjugates of tocopherol-salicylic acid derivatives and preparation method thereof Download PDFInfo
- Publication number
- KR930023357A KR930023357A KR1019920007662A KR920007662A KR930023357A KR 930023357 A KR930023357 A KR 930023357A KR 1019920007662 A KR1019920007662 A KR 1019920007662A KR 920007662 A KR920007662 A KR 920007662A KR 930023357 A KR930023357 A KR 930023357A
- Authority
- KR
- South Korea
- Prior art keywords
- tocopherol
- salicylic acid
- hydrogen
- general formula
- acid derivative
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims abstract 9
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 125000000217 alkyl group Chemical group 0.000 claims abstract 3
- 125000001589 carboacyl group Chemical group 0.000 claims abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 claims 1
- 150000003611 tocopherol derivatives Chemical class 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000003078 antioxidant Effects 0.000 abstract 1
- 230000002093 peripheral Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000010926 purge Methods 0.000 abstract 1
- 230000036269 ulceration Effects 0.000 abstract 1
Abstract
본 발명은 다음 일반식(Ⅰ)의 토코페롤- 살리실산 유도체의 콘주게이트 화합물을 제공하는 것이며,The present invention provides a conjugated compound of the following tocopherol-salicylic acid derivative of general formula (I),
식중 R은 수소, 탄산수 1-4의 저급알킬, 탄소수 1-4의 저급알카노일이며, R1, R2및 R3는 각각 수소원자 또는 메틸기이다.(단, R1, R2및 R3는 동시에 수소원자는 아니다.)Wherein R is hydrogen, lower alkyl of 1-4 carbon atoms, lower alkanoyl of 1-4 carbon atoms, and R 1 , R 2 and R 3 are each a hydrogen atom or a methyl group, provided that R 1 , R 2 and R 3 Is not a hydrogen atom at the same time.)
상기 일반식(Ⅰ)의 토코페롤-살리실산 유도체의 콘주게이트 화합물은 우수한 향산화효과 및 말초순화게선 효과를 가지고 있으나 궤양형성효과는 낮은 우수한 약리효과를 가진다.The conjugate compound of the tocopherol-salicylic acid derivative of the general formula (I) has excellent antioxidative effect and peripheral purge effect, but ulceration effect has low excellent pharmacological effect.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
제 1도는 토코페롤- 아스피린 콘주게이트의 NMR 챠트이며, 제 2도는 토코페롤- 살리실산 콘주게이트의 NMR챠트이다.FIG. 1 is an NMR chart of the tocopherol-aspirin conjugate, and FIG. 2 is an NMR chart of the tocopherol-salicylic acid conjugate.
Claims (2)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930023357A true KR930023357A (en) | 1993-12-18 |
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