KR960009644B1 - Micro multiple sphere composition containing cosmetic component with skin activity and its preparation - Google Patents

Abstract

The micro multiple sphere is composed of 2-20 wt% cosmetic component having skin activity, 0.01-5 wt% ceramide, 0.01-5 wt% sitosterol and 0.01-5 wt% cholesterol. The manufacturing method of the micro multiple sphere is composed of 5 processes: the first process melts glycerin, cetylphosphate and distilled water under 60-120 deg.C.; the second melts ceramide, sitosterol and cholesterol under 60-150 deg.C.; the third cools after the mixture of the components from the above processes damps under 60-150 deg.C. The forth makes micro multi lamella structure by passing the mixture of the component of the third process and the skin active cosmetic component melted by 40-80 deg.C through a high pressure mixer. The fifth cools the mixture of the component of the forth process and distilled water containing a preservative to 20-40 deg.C.

Description

Micro Multiple Sphere Composition Containing Skin-Activated Beauty Ingredients and Its Manufacturing Method

Figure 1 is a frozen cut electron micrograph (160,000 magnification) of the micro-small microspheres containing a vitamin complex as a skin active cosmetic ingredient according to the present invention.

Figure 2 is a frozen cut electron micrograph (130,000 magnification) of the micro-polymorphic spheres containing the bioactive complex as a skin active cosmetic ingredient according to the present invention.

Figure 3 is a frozen cut electron micrograph (100,000 magnification) of the micro-small microspheres containing the herbal herbal complex as a skin active cosmetic ingredient according to the present invention.

The present invention relates to a micro multiple sphere containing a skin active ingredient (Micro Multiple Sphere) and a method for manufacturing the same, and more particularly contained in cosmetics to prevent aging of the skin, physiological function of the skin and skin protection function When skin-active beauty ingredients such as water-soluble, fat-soluble vitamins, bioactive ingredients extracted from animals and plants, or Chinese Herbs (China Herb) that have various functions such as The present invention relates to a microsphere lamellar structure globule composition containing a skin active cosmetic ingredient and to a method for producing the same so that the sustained release of the ingredient and the ingredient preservation ability can be greatly improved.

Recently, various cosmetic products include moisturizers such as glycerin, propylene glycol, 1,3-butylene glycol, oils such as hydrocarbons, fatty acids, fatty acid esters, and various sterols. In addition to the ingredient supplements, skin active beauty ingredients such as various water-soluble, fat-soluble vitamins, bioactive ingredients extracted from animals and plants, or herbal herbal medicine ingredients are added to the skin for application of moisture and evaporation of moisture due to body temperature. In addition to the simple function of the conventional cosmetics to compensate for the damage to sebum components in accordance with the moisturizing function and skin drying to inhibit it has been given the function to prevent the aging of the skin, and activate the physiological function of the skin.

However, there is a problem that can not properly exhibit the function due to the following unique properties when added to the skin active beauty ingredients in a simple mixing method.

That is, various water-soluble and fat-soluble vitamins are mostly unstable, and since they are easily oxidized, discolored, and destroyed by oxygen, light, and heat in the air, their inherent actions and ingredients are difficult to preserve when they are simply mixed in cosmetics. In addition, most of the animal and vegetable bioactive ingredients have a polymer structure and a large molecular weight, so it is difficult to penetrate and absorb into the epidermis as well as the dermis when applied to the skin, and sensitive beauty ingredients uniquely obtained by biotechnology In addition to the main ingredients, saponins, glycosides such as tannins, flavonoids, carotenoids and other monosaccharides, polysaccharides, polysaccharides, amino acids, proteins, vitamins, minerals, etc. Since there are many substances, the amount of use There was a problem in the selection of raw materials and securing the stability of the product. Also, herbal herbal ingredients have been recognized for their safety through long clinical experience, but their inherent pharmacological action is slow, so that they are difficult to obtain fast effects.

As a result, it is possible to initially select the release rate, release time, and release location of the components, such as drug delivery system or release control function (Slow release effect), which are widely used in the pharmaceutical industry in the cosmetic field. Attempts have been made to allow for control. As part of this effort, volatilization of low boiling point components can be achieved by liposomes or microcapsules using coacervation or in-situ neutralization. It is effective by applying the globules containing skin-active beauty ingredients with such functions while preventing, concealing color and taste odors, powdering liquids, reducing toxicity, and improving the stability of the product. The functional improvement by stabilization of ingredients, the provision of new effects by the stable blending of new active ingredients, the degree of freedom of composition by the powdering of liquids, and the effect of giving new forms of products were brought.

However, as shown in Table 1, the globules containing such skin-active cosmetic ingredients show a somewhat improved effect compared to the conventional simple mixing method, but have a relatively large particle size of 1 to 500 µm and constitute a globule membrane. Due to the nature of the material, the preservation power of the active ingredient is reduced, and because the release and penetration of the cosmetic ingredient is instantaneous, there was a problem that the inherent functions and effects of the skin active beauty ingredient can not be sufficiently exhibited.

[Table 1] Types and characteristics comparison table of various globules

The present invention has been made in order to solve the above-mentioned conventional problems, the object of the present invention is a skin active beauty component such as a water-soluble, fat-soluble vitamin complex, or a bioactive complex or herbal medicine complex extracted from animals and plants of the human body skin By using microceramic glomeruli with ceramide, cytosterol and cholesterol, which are similar to the intercellular lipid component of the stratum corneum, it improves the skin penetration of the component when applied to the skin and inherently contains the active skin active ingredients. The present invention provides a micromulti-sphere globules containing skin active cosmetic ingredients of a new micro-multiple lamella structure that can maintain a more stable state by improving the preservation of ingredients while improving the function and effect of the same.

In addition, an object of the present invention, in the method for producing a micro-multi globule containing the skin active cosmetic ingredients, the ceramide, cytososterol, cholesterol similar to the interstitial lipid component of the stratum corneum layer by a solvent or heating method, The dissolved components are mixed uniformly with each skin active beauty ingredient, and then formed into a micro multiple lamella structure by using a high pressure micro homogeneous mixer to form a micro multiple lamella structure, and thus the skin's percutaneous absorption ability is excellent. The present invention provides a method for producing globules having a micromultiple lamellar structure containing a novel skin active cosmetic ingredient capable of improving sustained release and ingredient preservation.

Hereinafter, the present invention will be described in more detail.

The micromultiple globules containing the skin active cosmetic ingredient according to the present invention contain 2.00 to 20.00 weight% of skin active beauty ingredient, 0.01 to 5.00 weight% of ceramide, and 0.01 to 5.00 weight% of cholesterol of 0.01 to 5.00 weight% of cholesterol.

In another aspect, the present invention provides a method for providing a micro-polyspheres containing the skin active cosmetic ingredient, the first step of heating and dissolving a portion of purified water and glycerin, cetyl phosphate and salts thereof at 60 to 120 ℃, ceramide, cytosterol In addition, the second step of hydrolyzing the cholesterol and cethes separately at 60-150 ° C. using a heating method or a solvent, and the components of the first step and the second step were wetted at 60-150 ° C. After cooling and dissolving the third step of cooling and skin active cosmetic ingredients to 40-80 ° C., the mixture is uniformly mixed with the wet and cooled raw material in the third step, and then a high-pressure micromixer having a pressure of 200 to 1000 Bar. The second step of the microspheres by passing through 2-3 times, and the preservatives are dissolved in the remaining amount of purified water, and then mixed with the fine multi-spheres obtained in the fourth step and then cooled to 20-40 ℃ to stabilize It is made of a fifth step of.

In the present invention, the skin active cosmetic ingredient is selected from a water-soluble, fat-soluble vitamin complex or animal and plant bioactive complex or herbal medicine complex, the water-soluble vitamins constituting the vitamin complex is a vitamin-C derivative, vitamin -B6 and the like, and fat-soluble vitamins are vitamin-A palmitate, vitamin-D, vitamin-E, and vitamin-F.

In addition, the animal bioactive components in the bioactive complex include Pracenta Extract, Hyaluronic Acid, Animal Protein, Yeast Extract, Collagen, Elastin, and the like. Plant bioactive ingredients are Rose hip oil, Macademia oil, Tea Extract, and the like.

In addition, the herbal herbal medicine constituting the herbal medicine complex is ginseng extract, Ganoderma lucidum extract, Angelica extract, licorice acid, royal jelly, yulmu extract, self-root extract, pearl calk extract, golden extract and the like.

On the other hand, the structure of the micropolysilicon produced by the present invention described above is a fine multi-lamellar structure, the particle size of the average of 0.05㎛ ~ 1㎛.

Such effects of the present invention are as follows.

The micromultiple globules containing the skin active cosmetic ingredient of the present invention contain a hydrophilic component and a lipophilic component, and since the material of the glomerular membrane is composed of lipids similar to the intercellular lipid components of the stratum corneum, irritation is It has almost no effect of excellent bio-friendliness, excellent stabilization and preservation of effective beauty ingredients, and has the function of continuously and stepwise release and penetrating cosmetic ingredients.

In addition, it is possible to blend a high concentration of skin active cosmetic ingredients in the micro-multi globules, and has an excellent effect on skin penetration when applied to the skin.

In addition, since the micromulti-spherical sphere according to the present invention is made of a fine multi-lamellar structure, it has an excellent effect on the transdermal absorption of skin.

The micromultiple globules containing the skin active cosmetic ingredient according to the present invention are described in more detail by the following examples, which are not intended to limit the present invention.

Example 1

The raw material of the micromultiple globules of the present invention prepared in this Example was used as described in Table 2, and was carried out in the following order.

(1) A part of constant water, glycerin, cetyl phosphate and salts thereof were heated and dissolved at a temperature of 60 to 120 ° C.

(2) Ceramides, cytosterols, cholesterol, and cetes were lyophilised by using a solvent or a heating method in a separate dissolution zone to 60 to 150 ° C.

(3) The components dissolved in (1) and (2) were uniformly mixed, wetted at 60 to 150 ° C, and then cooled.

(4) After dissolving the water-soluble vitamins and a part of purified water to 40 ~ 80 ℃, uniformly mixed with the raw materials wet in the above (3), using a high pressure micro homogenizer of 200 ~ 1000 Bar pressure, 1 Primary microspheres.

(5) The remaining fat-soluble vitamins, except for vitamin-A palmitate, were dissolved by heating at 40 to 80 ° C., cooled, and completely dissolved by adding vitamin-A palmitate.

(6) After homogenizing the primary microspherolized components in (4) and the fat-soluble nontanminols dissolved in (5) using a turbine stirrer, using a high pressure micro homogenizer of 200 to 1000 Bar pressure again. 3 times through the micromultiple glomeruli.

(7) After dissolving the remaining amount of purified water and preservative, it is mixed with the micromultiple globules formed in (6), and then cooled and stabilized to 20-40 ° C. to contain the skin-active cosmetic ingredient (vitamin complex) of the present invention. One micromultiple globules were prepared.

TABLE 2 Component Contents of Examples 1, 2 and 3

Example 2

The raw material of the micromultiple globules of the present invention prepared in this Example was used as described in Table 2, and was carried out in the following order.

(1) A part of purified water and glycerin were heated and dissolved at a temperature of 60 to 120 ° C.

(2) Ceramide, cytosterol, and cholesterol were separately dissolved in a dissolution unit by heating to a temperature of 60 to 150 ° C. for homogenization.

(3) After uniformly mixing the components dissolved in the bowling machines (1) and (2), the mixture was wetted at a temperature of 60 to 150 ° C. and then cooled.

(4) Animal plant bioactive components were subjected to primary to third microspheres under the same conditions as in Example (4).

(5) A micromultiple globule containing the skin active cosmetic ingredient (bioactive complex) of the present invention was prepared under the same conditions as in (7) of Example 1.

Example 3

In this embodiment, the raw material of the micromultiple globules of the present invention was used as described in Table 2, and was carried out in the following order.

(1), (2) and (3) were implemented on the conditions similar to (1), (2), (3) of the said Example 2.

(4) The herbal herbal composites were subjected to the same conditions as in Example 4 (4) to form primary to third microspheres.

(5) The micromulti-spheres containing the skin active cosmetic ingredient (herbal herbal medicine complex) of the present invention were prepared under the same conditions as in (7) of Example 1.

Experimental Example

Structures and particles of the micromultiple globules containing the vitamin complex of the present invention prepared in Examples 1, 2, and 3, the micromultiple globules containing the bioactive complex, and the micromultiple globules containing the herbal medicine complex In order to measure the size, the following cryocleaving electron microscope confirmation experiment was performed.

Freeze-cutting electron microscopic confirmation of micromultiple glomeruli.

1. Preparation of Sample

A small amount of samples taken from each of the micromultiple globules prepared in Examples 1, 2, and 3 is placed in a rivet space, and a short hair serving as a reinforcing support is inserted.

The support is placed in slightly cold nitrogen, cooled, and placed in a Biotech 2005 Freeze Fracture Unit. The sample is cut at a vacuum of 10 ⁻⁶ Torr or higher and −140 ° C. This cut plane is immediately projected in Pt / C at an angle of 45 ° C. RIVE T / Sample / Replica side is removed from the freezing unit, the duplicate side is floated in warm distilled water, then removed and rinsed in clean distilled water three times, then placed on a 400 mesh scanning electron microscope grid and dried for 12 hours. Put the grid in chromoform 20 times and dry.

2. Sample observation and shooting

Each sample prepared above was observed with a scanning electron microscope (Joel 1200EX), photographed at 160,000 magnification, 130,000 magnification, and 100,000 magnification, respectively, and shown in FIGS. 1, 2, and 3. .

3. Freezing electron micrograph description

① Figure 1: Frozen microscopic electron micrograph of the micromultiple globules of the vitamin complex is 160,000 times higher magnification. Many microspheres exist, and the average size is 0.1㎛ and sometimes larger globules are seen. As you can see in the picture, it shows that it has a multi lamella structure.

② FIG. 2: The frozen-cut electron micrograph of the micromultiple globules of the bioactive composite is a magnification of 130,000 times higher. As can be seen from the photo, it can be seen that there are many micromultiple globules. Its average size is 0.1 μm, and it shows that most of them have a multi lamella structure.

③ FIG. 3: Frozen micrograph of microsphere globules of herbal medicine composites. Magnified at 100,000 times higher magnification. As can be seen from the photo, many microspheroids exist as they are. Its average size is 0.1 μm, which shows that it forms almost a multi lamellae structure.

As can be seen from the freezing and cutting micrograph of the micro-multi globules containing the skin active cosmetic ingredient of the present invention as described above, the micro-multi globules according to the present invention maintain a stable state, and accordingly various skin active cosmetics It improves skin penetration and absorption when the ingredient is applied to the ingredient and applied to the skin, and the cosmetic effect can be continuously increased by the continuous release of the beauty ingredient.

Claims (2)

In the globule composition containing the skin active cosmetic ingredient, 0.01 to 5.00% by weight of ceramide, 0.01 to 5.00% by weight of sitosterol and 0.01 to 5.00% by weight of cholesterol with respect to the total cosmetic composition, and the average particle size of the globules is 0.05 to A micromultiple glomerular composition, having a microlamellar structure of 1 μm. A first step of heating and dissolving a portion of purified water, glycerin, cetylphosphate and salts thereof at 60 to 120 ° C, a second step of heating and dissolving ceramide, cytosterol, cholesterol, and cetes to 60 to 150 ° C, and the first step After mixing the components dissolved in the process and the second step uniformly, the third step of wet and then cooled at 60 ~ 150 ℃, and heating and dissolving the skin active cosmetic ingredients and a portion of purified water to 40 ~ 80 ℃ In the third step, a homogeneous mixing with the wet-cooled raw material and then a high-pressure micro homogeneous mixer with a pressure of 200 to 1000 Bar is carried out one to three times to microsphere into a fine multilamellar structure, and a preservative is added to the remaining purified water. After dissolving, mixing with a micro-lamellar globule obtained in the fourth step, followed by a fifth step of stabilizing by cooling to 20-40 ℃. A method for producing a fine multiple globules containing.