KR960007691B1 - Drug dispenser - Google Patents

Abstract

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Description

Pharmaceutical dispenser

The present invention provides a multi-layered film form for long-term sustained release of 1-ethynyl-2-methynyl-2-pentenyl-glysanate (hereinafter referred to as "the corresponding drug"), a vaporizing agent known as a pesticide. It relates to a drug dispenser.

To date, insect-proof sheets in which 1-ethynyl-2-methynyl-2-pentenyl-glysan mate is impregnated in paper or the like are known.

Moreover, as a chemical | medical agent dispenser of the type which releases a vaporizable chemical | medical agent, the chemical | medical agent is discharged from the side surface of the laminated sheet which has a barrier layer of a chemical | medical agent on both surfaces of the layer containing a chemical | medical agent (Patent No. 58-11145). And releasing a drug containing a drug (Japanese Patent Application Laid-Open No. 59-25319) and the like are known.

However, the former drug dispenser has a short-term effect of the drug (short-term persistence), which may cause discoloration and contact for release when contacted with a metal-copper paper or a package printed with an ink containing metal-copper. There is a problem of discoloration or staining in the upstream of the stomach (hereinafter referred to as copper injury), and the drug dispenser disclosed in Japanese Patent Laid-Open No. 58-11145, because the drug is released from the side of the laminated sheet. Although the initial release rate is large and the release rate becomes small after a very short period of time, the release rate is difficult to be constant, and the effect of the rapid drop in drug efficacy and some sustained release effect is expected. Since the surface area which releases a drug with respect to the volume of an intermediate layer is large, What has that problem.

It is an object of the present invention to provide a multi-layered drug dispenser that exhibits efficacy by releasing a vaporizable drug over a long period of time and at a constant sustained release rate as much as possible.

The present inventors conducted a detailed study on the film-form pharmaceutical dispenser which releases evaporative drug 1-ethynyl- 2-methynyl- 2-pentenyl- glycansmate for a long time. As a result, the present inventors have found out the relationship between the drug absorbed amount of the resin constituting the dispenser and the drug of the dispenser, and again found that the above-described copper injury can be prevented, thereby completing the present invention.

That is, this invention relates to the multilayer film-form chemical | medical agent dispenser which consists of the inner layer of next (i) and the outer layer of (ii) which contact | connects both surfaces of this inner layer.

(Iii) Resin (hereinafter referred to as "resin (I)") having a saturated water absorption of 20 wt% or more with respect to 1-ethynyl-2-methynyl-2-pentenyl-glyceric acid mate (hereinafter referred to as "resin (I)"), and this saturation An inner layer made of a composition containing the drug in an amount corresponding to 1 to 90% of the amount of the resin.

(Ii) An outer layer made of a resin (hereinafter referred to as "resin (II)") having a saturated water absorption at 20 ° C. of the drug to be less than 40% by weight, which is 0.1% by weight or more.

In the present invention, 1-ethynyl-2-methynyl-2-pentenyl-glysansmate is a low-odor agent having not only an insecticidal effect but also an insect repellent effect. The drug is rapidly and uniformly diffused within the resin (I) or the resin (II), and is evaporated to a moderate degree under normal use conditions to exhibit drug efficacy. This drug is marketed, for example, as a venturine of Sumitomo Chemical Co., Ltd ..

The saturated absorption amount with respect to the said chemical | medical agent of resin (I) or resin (II) is the maximum amount of the chemical | medical agent obtained by absorbing resin when these resins are immersed in the said liquid formulation.

Resin (I) used by this invention is a saturated absorption amount with respect to the said chemical | medical agent at 20 degreeC is 8.0 weight% or more, More preferably, it is 10.0 weight% or more. When a resin with a saturated water absorption of less than 8.0% by weight is used, the amount of the drug required for long-term sustained release may exceed the amount of saturated water absorbed, and the controlled release may not be controlled, and the amount of the drug to be mixed is saturated. Since it becomes high with respect to absorption amount, it becomes difficult to make a stable state, and the slow release effect excellent in the precision cannot be expected.

Specific examples of the resin (I) include an ethylene-vinyl acetate copolymer, an ethylene-methyl (meth) acrylate copolymer, and an ethylene-in terms of the saturation absorption amount, the safety with respect to the drug, the diffusion rate of the drug, and the moldability. Copolymers with ethylene and monomers having polar groups, such as ethyl acrylate copolymers and ethylene-vinyl acetate-methyl (meth) acrylate copolymers, among which copolymers containing 3 mol% or more of monomers having polar groups desirable. Especially preferred is an ethylene-vinyl acetate copolymer obtained by copolymerizing vinyl acetate at least 3 mol%.

The quantity of the said chemical agent in the composition which consists of resin (I) and the said chemical | medical agent is an amount corresponding to 1 to 90% of saturated absorption amount with respect to the said chemical | medical agent of resin (I), More preferably, it is an amount corresponding to 5 to 80%.

When the amount of the drug is less than 1% of the saturated absorption amount, the amount of the drug is excessively used, and thus the drug does not show its effect from the beginning. Moreover, when it exceeds 90%, it will not be in a stable state as a composition, but a severe bleed will generate | occur | produce, and long-term slow release effect cannot be expected.

Resin (II) used by this invention is less than 0.1 weight%, More preferably, it is 0.5 to 2.0 weight% of saturated absorption amount with respect to the said chemical | medical agent at 20 degreeC.

When the saturation absorption is less than 0.1% by weight, the release amount does not reach the level of efficacy, and when it is 4.0% by weight or more, a dispenser showing a long-term sustained release effect is not obtained.

Examples of such resin (II) include low density polyethylene, medium density polyethylene, high density polyethylene, polypropylene or ethylene-butene copolymer, ethylene-hexene copolymer, ethylene-α-olefin air such as ethylene-4-methylpentene-1 copolymer. Copolymers such as copolymers with ethylene containing 2 mol% or less of a monomer having a polar group and a monomer having a polar group, and the like, include ethylene-vinyl acetate copolymer and ethylene-methyl (meth) acrylate. A copolymer, an ethylene-ethyl acrylate copolymer, an ethylene-vinyl acetate-methyl (meth) acrylate copolymer, etc. can be illustrated, These can be used independently, and can also be used in mixture of 2 or more types. Particularly preferred as the resin (II) is an ethylene-vinyl acetate copolymer containing 2 mol% or less of vinyl acetate. Moreover, the release amount of the said chemical | medical agent from each layer can also be adjusted by using two types of resin from which the saturated absorption amount with respect to the said chemical | medical agent is used as resin (II) used for two outer layers.

The thickness of the multi-layered drug dispenser of the present invention is preferably from 40 to 200 μm in terms of long-term sustained release and release at a constant rate, and economically, and the film thickness of the inner layer with respect to the entire thickness is 60 to 90%. can do.

In the present invention, antioxidants, ultraviolet absorbers, antistatic agents, preservatives, etc., in the range that does not impair the object of the present invention, such as greatly changing the saturated absorption amount of the resin of resin (I) or resin (II), for example, A lubricant, an antiblocking agent, a pigment, etc. can be used together suitably.

The manufacturing method of the multi-film drug dispenser of this invention is illustrated. First, the resin (I), the drug and the antioxidant and the anti-blocking agent, etc. are kneaded by a conventional method using a roll or banbury type kneader or an extruder or the like as necessary to obtain a composition. Alternatively, the composition is obtained by kneading the resin (II) and, if necessary, an antioxidant, an anti-blocking agent and the like by a conventional method using a roll or banbury kneader or an extruder. Subsequently, the obtained composition and the hybrid are coextruded simultaneously to obtain a multilayer film-form pharmaceutical dispenser according to inflation processing or T-die processing. As another manufacturing method, there is also a method of producing a film dispenser by first preparing a film according to inflation processing, T-die processing or calendar processing in a composition, and then laminating a kneaded product containing resin (II) on the film.

의 증산량을 장기간에 걸쳐 조절할 수 있고, 증산하기 쉬운 베퍼스린

의 증산량의 정량적인 장기지속의 효과는 놀랍게도 양호하며, 베퍼스린

그 자체의 효과를 살려서 의료(衣料) 포장, 의료 보존용의 방출 필름으로서 극히 유용하다.According to the present invention, Besperlin as a multi-layered pharmaceutical dispenser

Besperlin which can regulate evaporation amount of for a long term, and is easy to evaporate

The long-term effect of quantitative increase in the amount of transpiration is surprisingly good.

Taking advantage of its own effects, it is extremely useful as a release film for medical packaging and medical preservation.

In addition, the besperlin-containing multilayer film pharmaceutical dispenser obtained according to the present invention does not cause discoloration even when it comes into contact with a wrapping paper printed with metallic copper, ink containing metal copper, or the like. At the same time, the problem that occurs can be solved, and at the same time, there is a surprising effect that the effect on pests such as moths and worms is excellent for a long time.

The following examples illustrate the invention, but these examples are illustrative only and are not intended to be limiting.

의 증산량은 일정 기간 후의 디스펜서 내부의 베퍼스린

농약도를 아세톤을 용매로 한 속슬레(Soxhlet) 압출기로 압축시킨 후, 기체 크로마토그래피(시마쯔 세이사꾸쇼사제품, GC-7A형, 액상 DEGS 2% 담체 크로모소르브(crromosorbw) AW DMCS 처리 100 내지 120메쉬의 1m 길이의 컬럼을 사용한다)로 정량하고, 산출한 것이다.Besperlin shown in Examples and Comparative Examples

The amount of increase in the Besperlin inside the dispenser after a certain period of time

Pesticides were compressed with a Soxhlet extruder using acetone as a solvent, followed by gas chromatography (manufactured by Shimadzu, Ltd., GC-7A, liquid DEGS 2% carrier chromosorbw AW DMCS 1 m long columns of 100-120 mesh treated).

에 대한 수지의 포화 흡수량은 수지를 40×10×0.5mm로 성형한 쉬이트를 20℃의 베퍼스린

에 침지하고, 일정 시간 후에 수지의 흡수가 포화에 달하는 시점에서의 흡수량 그때의 중량에 대한 비율을 포화 흡수량으로 한 것이다.Besperlin shown in Examples and Comparative Examples

The saturated absorption amount of resin with respect to

It is immersed in and the ratio with respect to the weight at the time of the water absorption at that time when water absorption reaches saturation after fixed time is made into the saturated water absorption.

In addition, the chemical injury test shown in the Example and the comparative example and the copper injury test which examine the discoloration by copper contact are performed by the following method, respectively.

Efficacy test: A film or sheet-like test piece is installed on the entire lower surface of a glass product of 90 mm ø in diameter, and a wire mesh (60 mesh) is provided at a height of 25 mm from this, and the target pest is radiated on the wire mesh, and then the width of the whole is widened. Place it in a 300 mm, 300 mm long, 150 mm high wooden filter box to investigate the pesticidal effects of the pests and list the time to 100% mortality.

Copper injury: Distribute several grams of metallic copper powder between 100mm film or sheet test specimens and woolen foils, sandwich them, and sandwich them between two sheets of about 100g of iron plate, and in an air oven at 50 ° C. After standing, the discoloration of the wool fabric and the presence or absence of stains were examined, and the degree thereof was expressed by the following five-step rating.

: Discoloration remarkably high, a lot of stains

: Many discoloration, many stains

: There is remarkable discoloration, and there is dirt

+: Slight discoloration observed

－: Discoloration, no stain observed

Example 1

H 2020, 베퍼스린

포화 흡수량(스미또모 가가꾸 고교(주식회사)제품, 순도 93%) 3중량부를 5ι의 밴버리 믹서에서 수지 온도 120 내지 130℃로 10분간 혼련한 후, 조립기에서 팰릿트를 제조한다. 2종 3층 인플레 다이스(구경 100mm)를 갖춘 다층 인플레 장치를 사용하고, 다이스의 내층에는 구경 40mm의 압출기를 통해서 상기 팰릿트를 용융대 170℃, 다이스 온도 150℃의 조건하에 9kg/시간의 토출량으로 공급한다. 외층에는 아세트산 비닐 함유량이 1.7몰%의 에틸렌-아세트산 비닐 공중합체(스미또모 가가꾸 고교(주식회사)제품, 에바테이트

D 2011, 베퍼스린

포화 흡수량 1.9중량%)를 용융대 170℃, 다이스 온도 150℃의 조건하에 4.6kg/시간의 토출량으로 공급하고, 각 층에 공급할 수지는 다이스의 내부에서 첩합한 3층 샌드위치 구조의 관상체를 팽창비(blow up ratio) 2.4, 프로스트 라인(frost line) 거리 200mm, 인취 속도 4.2m/분의 조건으로 인취하고, 절경(折徑) 365mm, 각 층의 두께가 하나는 외층 0.02mm, 내층 0.06mm, 또 하나는 외층 0.02mm로 구성된 3층 샌드위치 구조인 다층 필름상 디스펜서를 수득한다. 수득된 디스펜서를 온도 23℃, 습도 50% RH에 조절한 상온 상습실에 방치하고, 베퍼스린

의 시간 경과에 따른 증산량의 변화를 측정한 다음, 그 결과를 표 1에 기재하였다. 또 대상 해충에 대한 약효 시험 및 구리 상해 시험의 결과를 표 2에 나타내었다.Ethylene-vinyl acetate copolymer (vinyl acetate content (product of Sumitomo Chemical Industries, Ltd.), ebatate

H 2020, Besperlin

3 parts by weight of saturated water absorption (manufactured by Sumitomo Chemical Co., Ltd., purity 93%) are kneaded at a resin temperature of 120 to 130 ° C. for 10 minutes in a Banbury mixer at 5 °, and then pellets are manufactured in a granulator. A multi-layer inflation device with two kinds of three-layer inflation dies (diameter 100 mm) was used, and the inner layer of the die was discharged at 9 kg / hour under conditions of a melt zone of 170 ° C. and a die temperature of 150 ° C. through an extruder having a diameter of 40 mm. To supply. Ethylene-vinyl acetate copolymer (product of Sumitomo Chemical Industries, Ltd., Evaate) of 1.7 mol% vinyl acetate content in an outer layer

D 2011, Besperlin

1.9 wt% of saturated water absorption) was supplied at a discharge amount of 4.6 kg / hour under conditions of a melting zone of 170 ° C. and a die temperature of 150 ° C., and the resin to be supplied to each layer was expanded in a tubular body having a three-layer sandwich structure bonded inside the die. (blow up ratio) 2.4, frost line distance 200mm, take-off speed of 4.2m / min, pulled down to 365mm, one layer thickness of each outer layer 0.02mm, inner layer 0.06mm, One obtains a multilayer film-shaped dispenser having a three-layer sandwich structure composed of an outer layer of 0.02 mm. The dispenser obtained was left to stand in a normal temperature and humidity room adjusted to a temperature of 23 ° C. and a humidity of 50% RH.

After measuring the change in the amount of transpiration over time, the results are shown in Table 1. Table 2 shows the results of the drug efficacy test and copper injury test on the pests.

Example 2

F 208-1, 베퍼스린

포화흡수량 0.4중량%)를 사용하고, 압출 조건을 용융대 180℃, 다이스 160℃로 변경한 이외에는 실시예 1를 반복하여 3층 샌드위치 구조의 다층 필름상 약제 디스펜서를 수득한다. 수득한 디스펜서의 성능을 표 2에 요약하였다.Instead of the ethylene-vinyl acetate copolymer used in the outer layer in Example 1, a low density polyethylene (Sumitomo Chemical Co., Ltd. product, Sumikasen)

F 208-1, Besperlin

Example 1 is repeated except that extrusion conditions were changed to melting zone 180 degreeC and die | dye 160 degreeC using saturated absorption amount 0.4weight%), and the multilayer film-form chemical | medical agent dispenser of a three-layer sandwich structure is obtained. The performance of the resulting dispenser is summarized in Table 2.

Example 3

포화흡수량 10.5중량%) 100중량부 및 베퍼스린

(스미또모 가가꾸 고교(주식회사)제품, 순도 93%) 3중량부로 이루어진 것으로 대신함을 제외하고는 실시예 1를 반복하여 디스펜서를 수득한다. 수득한 디스펜서의 성능을 표 1, 표 2에 요약하였다.In Example 1, the ethylene-vinyl acetate-methyl methacrylate terpolymer of 4.4 mol% of vinyl acetate content and 0.9 mol% of methyl methacrylate content was made into the inner layer pallet (Besperlin

Saturated absorption 10.5% by weight) 100 parts by weight and besperlin

(Sumitomo Kagaku Kogyo Co., Ltd. product, purity 93%) Except for having replaced by 3 parts by weight, Example 1 was repeated to obtain a dispenser. The performance of the obtained dispenser is summarized in Table 1, Table 2.

Example 4

포화흡수량 12.6중량%) 100중량부 및 베퍼스린

(스미또모 가가꾸 고교(주식회사)제품, 순도 93%) 3중량부로 이루어진 것으로 대신함을 제외하고는 실시예 1를 반복하여 디스펜서를 수득한다. 수득한 디스펜서의 성능을 표 1, 표 2에 요약하였다.Ethylene-methyl methacrylate copolymer of methyl methacrylate content 6.5 mol% (the besperlin was made into the inner layer pallet in Example 1

Saturated absorption 12.6% by weight) 100 parts by weight and besperlin

(Sumitomo Kagaku Kogyo Co., Ltd. product, purity 93%) Except for having replaced by 3 parts by weight, Example 1 was repeated to obtain a dispenser. The performance of the obtained dispenser is summarized in Table 1, Table 2.

Example 5

포화 흡수량 10.5 중량%) 100중량 % 및 베퍼스린

(스미또모 가가꾸 고교(주식회사)제품, 순도 93%) 2중량부를, 5ι의 밴버리 믹서에서 수지 온도 120 내지 130℃로 10분간 혼련한 후, 조립기에서 팰릿트를 제조한다. 3종 3층 인플레 다이스(구경 100mm)를 갖춘 다층 인플레 장치를 사용하고, 다이스의 내층에는 구경 40mm의 압출기를 통해서 상기 팰릿트를 용융대 170℃, 다이스 온도 160℃의 조건하에 9kg/시간의 토출량으로 공급하고, 하나의 외층에는 메틸메타크릴레이트 함유량이 1.7몰%의 에틸렌-메틸메타크릴레이트 공중합체(베퍼스린

포화 흡수량 1.5중량%)를 용융대 170℃, 다이스 온도 160℃의 조건하에 4.6kg/시간의 토출량으로 공급하고, 또 하나의 외층에는 저밀도 폴레에틸렌(스미또모 가가꾸 고교(주식회사)제품, 스미카센

F 208-1, 베퍼스린

포화 흡수량 0.4중량%)을 용융대 180℃, 다이스 온도 160℃의 조건하에 4.6kg/시간의 토출량으로 공급한 다음, 각 층에 공급한 수지는 다이스 내부에서 첩합한 3종 3층 구조의 관상체를 팽창비 2.4, 프로스트 라인 거리 200mm, 인취 속도 4.2m/분의 조건으로 인취하고, 절경 365mm, 각 층 두께가 하나는 외층 0.02mm, 내층 0.06mm, 또 하나는 외층 0.02mm로 구성된 3종 3층 구조의 다층 필름상 디스펜서를 수득한다. 수득된 디스펜서를 온도 23℃, 습도 50% RH에 조절한 상온 상습실에 방치하고, 베퍼스린

의 시간 경과에 따른 증산량의 변화를 측정한 다음, 그 결과를 표 1에 나타내었다. 또 대상 해충에 대한 약효 시험 및 구리 상해 시험의 결과를 표 2에 나타내었다.Ethylene-vinyl acetate-methyl methacrylate tertiary copolymer having 4.4 mol% vinyl acetate content and 0.9 mol% methyl methacrylate content (Besperrin

Saturated absorption 10.5% by weight) 100% by weight and besperlin

(Sumitomo Kagaku Kogyo Co., Ltd. product, purity 93%) 2 parts by weight are kneaded at a resin temperature of 120 to 130 ° C. for 10 minutes in a Banbury mixer of 5 °, and then pellets are manufactured in a granulator. Using a multi-layer inflation device equipped with three types of three-layer inflation dies (diameter 100 mm), the inner layer of the die was discharged at 9 kg / hour under conditions of a melt zone of 170 ° C. and a die temperature of 160 ° C. through an extruder having a diameter of 40 mm. Ethylene-methyl methacrylate copolymer having a methyl methacrylate content of 1.7 mol% in one outer layer

Saturated absorption amount 1.5% by weight) was supplied at a discharge rate of 4.6 kg / hour under conditions of a melting zone of 170 ° C. and a die temperature of 160 ° C., and another density of low density polyethylene (Sumitomo Chemical Co., Ltd.) and Sumikasen

F 208-1, Besperlin

0.4 wt% of saturated water absorption) was supplied at a discharge amount of 4.6 kg / hour under conditions of a melting zone of 180 ° C. and a die temperature of 160 ° C., and then the resin supplied to each layer was formed of a tubular body of three types and three layers, which were bonded inside the die. 3, three layers composed of expansion ratio 2.4, frost line distance 200mm, pulling speed 4.2m / min, the diameter of 365mm, each layer thickness is one outer layer 0.02mm, inner layer 0.06mm, one outer layer 0.02mm A multilayer film-shaped dispenser of structure is obtained. The dispenser obtained was left to stand in a normal temperature and humidity room adjusted to a temperature of 23 ° C. and a humidity of 50% RH.

After measuring the change in the amount of transpiration over time, the results are shown in Table 1. Table 2 shows the results of the drug efficacy test and copper injury test on the pests.

Example 6

S 5008) 20중량%와 저밀도 폴레에틸렌(스미또모 가가꾸 고교(주식회사)제품 스미카센

F 208-1) 80중량%의 블랜드 조성물(베퍼스린

포화흡수량 0.3중량%)을 사용하고, 압출 조건을 용융대 210℃, 다이스 온도 160℃로 변경함을 제외하고는 실시예 4를 반복하여 3층 샌드위치 구조의 다층 필름상 약제 디스펜서를 수득한다. 수득한 디스펜서의 성능을 표 1, 표 2에 요약하였다.High-density polyethylene (Shoresk from Showa Menko) was used instead of the ethylene-vinyl acetate copolymer used in the outer layer in Example 4.

S 5008) 20% by weight and low density polyethylene (Sumitomo Kagaku Kogyo Co., Ltd.) Sumikasen

80% by weight of the blend composition (befferrin

Example 4 was repeated except that extrusion conditions were changed to melt zone 210 degreeC and die temperature 160 degreeC using the saturated absorption amount 0.3weight%), and the multilayer film-form pharmaceutical dispenser of a 3-layer sandwich structure was obtained. The performance of the obtained dispenser is summarized in Table 1, Table 2.

Comparative Example 1

의 시간 경과에 따른 증산량의 변화를 측정하여, 그 결과를 표 1에 나타내었다. 또 대상 해충에 대한 약효 시험 및 구리 상해 시험의 결과를 표 2에 나타내었다.Using a pellet used in Example 1, using a bore 50 mm extruder with a spiral die having a diameter of 100 mm, the tubular body was expanded under conditions of a melt zone of 180 ° C. and a die temperature of 177 ° C., an expansion ratio of 2.4, a frost line distance of 200 mm, and a pulling speed of 5 m. A single layer film having a thickness of 0.1 mm was obtained under the condition of / min. The obtained film was left to stand in the normal temperature and humidity room adjusted to the temperature of 23 degreeC, and 50% of humidity, and besperlin.

The change in the amount of transpiration over time was measured, and the results are shown in Table 1. Table 2 shows the results of the drug efficacy test and copper injury test on the pests.

Comparative Example 2

D 2011, 베퍼스린

포화 흡수량 1.9중량%) 100중량부 및 베퍼스린

2중량부로부터 실시예 1과 동일한 방법으로 팰릿트를 수득하고, 이를 사용하여 비교 실시예 1과 동일한 방법으로 0.1mm두께의 단층 필름을 수득한다. 수득한 필름의 성능을 표 1, 표2에 기재하였다.Ethylene-vinyl acetate copolymer (The Sumitomo Chemical Co., Ltd. product, Evaate) which has the same vinyl acetate content of 1.7 mol% as used for the outer layer of Example 1

D 2011, Besperlin

Saturated absorption 1.9% by weight) 100 parts by weight and besperlin

Pallets were obtained in the same manner as in Example 1 from 2 parts by weight, and a single layer film having a thickness of 0.1 mm was obtained in the same manner as in Comparative Example 1. The performance of the obtained film is shown in Table 1 and Table 2.

Comparative Example 3

3중량부를 혼련하여 팰릿트로 함) 함을 제외하고는 실시예 1과 동일한 방법으로 다층 필름을 수득한다. 수득한 필름의 성능을 표 1, 표2에 기재하였다.In Example 1, the resin used for the pallet and the resin used for the outer layer were all used in reverse (that is, 100 parts by weight of the ethylene-vinyl acetate copolymer used for the outer layer and besperine

A multilayer film is obtained in the same manner as in Example 1 except for kneading 3 parts by weight to pellet). The performance of the obtained film is shown in Table 1 and Table 2.

Comparative Example 4

을 중질지에 인쇄하여 600mg/㎡ 함침된 종이를 수득한다. 수득한 베퍼스린

함침지의 성능을 표 1, 표 2에 기재하였다. 또, 실시예, 비교 실시예에 사용된 수지 및 필름의 두께는 표3에 나타내었다.Besperlin with a gravure printing machine using heavy paper (thickness 70μ, basis weight 62g) of more than 70% chemical pulp

Was printed on heavy paper to give 600 mg / m 2 impregnated paper. Obtained Besperlin

The performance of the impregnated paper is shown in Table 1 and Table 2. In addition, the thickness of the resin and film which were used for the Example and the comparative example is shown in Table 3.

Besperlin concentration in inner layer

Besperlin Saturated Absorption

A: Ethylene-vinyl acetate copolymer 5.4 mol% 10.9 weight% of vinyl acetate content

B: Ethylene-vinyl acetate copolymer 1.7 mol% 1.9 weight% of vinyl acetate content

C: 0.4% by weight of low density polyethylene

D: 0.3% by weight of high density polyethylene / low density polyethylene blend composition

E: Ethylene-Vinyl Acetate-Methyl Methacrylate Copolymer

Vinyl acetate content 4.4%

Methyl methacrylate content 0.9 mol% 10.5 wt%

F: Ethylene-Methyl Methacrylate Copolymer

Methyl methacrylate content 6.5 mol% 12.6 wt%

G: ethylene-methyl methacrylate copolymer

Methyl methacrylate content 1.7 mol% 1.5 weight%

Claims (1)

Resin whose 20 degreeC saturated absorption amount is 18.0 weight% or more with respect to 1-ethynyl- 2-methynyl- 2-pentenyl- glycan smate (henceforth "the drug"), and 1-90 of the said saturated absorption amount. Inner layer consisting of a composition containing the drug in an amount corresponding to%, and an outer layer made of a resin having a saturated water absorption at 20 ° C. of the drug at least 0.1% by weight and less than 4.0% by weight and in contact with both surfaces of the inner layer ( Ii) a multilayer film-like drug dispenser.