KR960007605A - New preparation method of cephalosporin derivative - Google Patents
New preparation method of cephalosporin derivative Download PDFInfo
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- KR960007605A KR960007605A KR1019940020025A KR19940020025A KR960007605A KR 960007605 A KR960007605 A KR 960007605A KR 1019940020025 A KR1019940020025 A KR 1019940020025A KR 19940020025 A KR19940020025 A KR 19940020025A KR 960007605 A KR960007605 A KR 960007605A
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- phenoxy
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Abstract
본 발명은 항생물질로 유용한 다음 일반식(I)로 베타-락탐 유도체의 새로운 제조방법에 관한 것으로서, 하기 일반식(Ⅳ)의 3-브로모메틸 또는 3-클로로메틸-7-페녹시(또는 페닐)아세트아미도-3-세펨-4-카복실산-1-옥사이드의 C3위치에 4-카바모일퀴노클리딘을 치환시켜 하기 일반식(Ⅴ)의 화합물을 제조하고; 화합물(Ⅴ)의 C7위치를 탈아실화반응시켜 하기 일반식(Ⅲ)의 화합물을 제조하며; 화합물(Ⅲ)과 하기 일반식(Ⅱ)의 화합물과를 아실화반응시켜 하기 일반식(I)의 세팔로스포린 유도체를 제조한다.The present invention relates to a novel method for preparing beta-lactam derivatives of the following general formula (I), which is useful as an antibiotic, and is formulated with 3-bromomethyl or 3-chloromethyl-7-phenoxy (or Phenyl) acetamido-3-cepem-4-carboxylic acid-1-oxide was substituted with 4-carbamoylquinoclidine at the C 3 position to prepare the compound of formula (V); Deacylation of the C 7 position of compound (V) to prepare a compound of formula (III); The acelation reaction of compound (III) with a compound of the following general formula (II) yields a cephalosporin derivative of the following general formula (I).
(상기 식중, X는 브롬 또는 염소 원자이고, R은 페녹시 또는 페닐기이며, R1은 할로겐화물, 알킬- 또는 아실옥시포스포니움 클로라이드 또는 파라히드록시트리아졸 치환기를 의미한다.)(Wherein X is a bromine or chlorine atom, R is a phenoxy or phenyl group, and R 1 means a halide, alkyl- or acyloxyphosphonium chloride or parahydroxytriazole substituent.)
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940020025A KR960007605A (en) | 1994-08-13 | 1994-08-13 | New preparation method of cephalosporin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940020025A KR960007605A (en) | 1994-08-13 | 1994-08-13 | New preparation method of cephalosporin derivative |
Publications (1)
Publication Number | Publication Date |
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KR960007605A true KR960007605A (en) | 1996-03-22 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1019940020025A KR960007605A (en) | 1994-08-13 | 1994-08-13 | New preparation method of cephalosporin derivative |
Country Status (1)
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KR (1) | KR960007605A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102398019B1 (en) * | 2021-07-16 | 2022-05-16 | (주) 페트로산업 | Flexible urethane waterproofing material with high adhesion, dual complex waterproof sheet including the same and complex waterproofing method using the same |
-
1994
- 1994-08-13 KR KR1019940020025A patent/KR960007605A/en not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102398019B1 (en) * | 2021-07-16 | 2022-05-16 | (주) 페트로산업 | Flexible urethane waterproofing material with high adhesion, dual complex waterproof sheet including the same and complex waterproofing method using the same |
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