KR960007601A - How to prepare cefem derivatives - Google Patents
How to prepare cefem derivatives Download PDFInfo
- Publication number
- KR960007601A KR960007601A KR1019940020023A KR19940020023A KR960007601A KR 960007601 A KR960007601 A KR 960007601A KR 1019940020023 A KR1019940020023 A KR 1019940020023A KR 19940020023 A KR19940020023 A KR 19940020023A KR 960007601 A KR960007601 A KR 960007601A
- Authority
- KR
- South Korea
- Prior art keywords
- methoxyimino
- iii
- reaction
- methoxybenzyl
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
본 발명은 세펨 유도체를 제조하기 위한 신규한 방법을 제공한다. 본 발명의 방법에 따르면 하기 일반식(Ⅱ)의 2-(Z)-메톡시이미노-2-(2-아미노티아졸-4-일)-아세트산을 트리에틸아민 존재하에 트리틸클로라이드와 반응시켜 하기 일반식(Ⅲ)의 2-(Z)-메톡시이미노-2-(2-트리틸아미노티아졸-4-일)-아세트산을 제조 하고; 얻어진 화합물을(Ⅲ)을 수용성 또는 비수용성 용매중에서 트리에틸아민의 존재하에 오염화인을 이용하여 클로리네이션시켜 하기 일반식(Ⅳ)의 2-(Z)-메톡시이미노-2-(2-트리틸아미노티아졸-4-일)-아세틸클로라이드를 제조하며; 얻어진 화합물(Ⅵ)의 수용성 또는 비수용성 용매중에서 탄산수소나트륨 수용액 존재하에 하기 일반식(Ⅴ)의 p-메톡시벤질(6R, 7R)-7-아미노-3-클로로메틸-세펨-4-카르복실레이트(CMC)와 반응시켜 하기 일반식(Ⅰ)의 p-메톡시벤질(6R, 7R)-7-[(Z)-2-메톡시이미노-2-(2-트리틸아미노티아졸-4-일)아세트아미도]-3-클로로메틸세펨-4-카르복실레이트를 제조한다.The present invention provides a novel method for preparing cefem derivatives. According to the method of the present invention, 2- (Z) -methoxyimino-2- (2-aminothiazol-4-yl) -acetic acid of formula (II) is reacted with tritylchloride in the presence of triethylamine 2- (Z) -methoxyimino-2- (2-tritylaminothiazol-4-yl) -acetic acid of the following general formula (III) was prepared; The obtained compound was cloned (III) using phosphorus pentachloride in the presence of triethylamine in an aqueous or non-aqueous solvent to give 2- (Z) -methoxyimino-2- (2- Tritylaminothiazol-4-yl) -acetylchloride; P-methoxybenzyl (6R, 7R) -7-amino-3-chloromethyl-cepem-4-car of the following general formula (V) in the presence of an aqueous sodium hydrogencarbonate solution in an aqueous or non-aqueous solvent of the obtained compound (VI). P-methoxybenzyl (6R, 7R) -7-[(Z) -2-methoxyimino-2- (2-tritylaminothiazole- of the following general formula (I): 4-yl) acetamido] -3-chloromethylcefe-4-carboxylate is prepared.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940020023A KR0130941B1 (en) | 1994-08-13 | 1994-08-13 | Process for preparing spermidin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940020023A KR0130941B1 (en) | 1994-08-13 | 1994-08-13 | Process for preparing spermidin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960007601A true KR960007601A (en) | 1996-03-22 |
KR0130941B1 KR0130941B1 (en) | 1998-04-16 |
Family
ID=19390321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940020023A KR0130941B1 (en) | 1994-08-13 | 1994-08-13 | Process for preparing spermidin derivatives |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR0130941B1 (en) |
-
1994
- 1994-08-13 KR KR1019940020023A patent/KR0130941B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR0130941B1 (en) | 1998-04-16 |
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E701 | Decision to grant or registration of patent right | ||
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