KR960004325A - Quinolone carboxylic acid derivatives and preparation method thereof - Google Patents

Quinolone carboxylic acid derivatives and preparation method thereof Download PDF

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Publication number
KR960004325A
KR960004325A KR1019940017883A KR19940017883A KR960004325A KR 960004325 A KR960004325 A KR 960004325A KR 1019940017883 A KR1019940017883 A KR 1019940017883A KR 19940017883 A KR19940017883 A KR 19940017883A KR 960004325 A KR960004325 A KR 960004325A
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South Korea
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compound
following general
formula
halogen atom
same
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KR1019940017883A
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Korean (ko)
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박상후
이경주
조성민
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이응열
주식회사 코오롱
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Priority to KR1019940017883A priority Critical patent/KR960004325A/en
Publication of KR960004325A publication Critical patent/KR960004325A/en

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Abstract

본 발명은 다음 일반식(Ⅰ)로 표시되는 새로운 퀴놀론산 유도체 및 이를 제조하는 방법에 관한 것으로, 다음 일반식(Ⅳ)의 화합물에 2-아미노-1-프로판올을 반응시켜서 제조된 다음 일반구조식(Ⅴ)의 화합물을 강염기의 존재하에 고리화반응을 행하여 다음 일반구조식(Ⅵ)의 화합물을 제조하고 이 화합물을 통상의 할로겐화 반응을 행하여 다음 일반구조식(Ⅶ)의 화합물을 제조한 후 이 화합물을 통상의 가수분해반응을 행하여 다음 일반구조식(Ⅰ)의 화합물을 제조한다.The present invention relates to a new quinolonic acid derivative represented by the following general formula (I) and a method for preparing the same, prepared by reacting 2-amino-1-propanol with a compound of the following general formula (IV) The compound of V) was cyclized in the presence of a strong base to prepare the compound of the following general structure (VI), and this compound was subjected to the usual halogenation reaction to produce the compound of the following general structure (VII). The hydrolysis reaction was carried out to prepare the compound of the following general structure (I).

상기식 중에서 R1은 할로겐원자, R2는 수소원자, 할로겐원자, 아미노기 또는 탄소수 1-3개의 저급알킬기를 나타내고 X1,X2및 X3는 서로 같거나 다른 할로겐원자를 나타낸다.Wherein R 1 represents a halogen atom, R 2 represents a hydrogen atom, a halogen atom, an amino group or a lower alkyl group having 1 to 3 carbon atoms, and X 1 , X 2 and X 3 represent the same or different halogen atoms.

본 발명의 일반식(Ⅰ)의 화합물은 기존의 항균화합물들의 항균활성의 취약성을 보완할 수 있는 새로운 퀴놀론 모핵 중간체로 유용이다.The compound of formula (I) of the present invention is useful as a new quinolone parent nucleus intermediate capable of supplementing the vulnerability of antimicrobial activity of existing antimicrobial compounds.

Description

퀴놀론 카르복실산 유도체 및 그 제조방법Quinolone carboxylic acid derivatives and preparation method thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

다음의 일반식(Ⅰ)로 표시되는 N-1 치환체의 비대칭 탄소로 생성되는 광학 이성질체를 포함하는 새로운 퀴놀론 카르복실산 유도체.New quinolone carboxylic acid derivative containing the optical isomer produced by the asymmetric carbon of the N-1 substituent represented by the following general formula (I). 상기식 중에서 R1은 할로겐원자, R2는 수소원자, 할로겐, 아미노기 또는 탄소수 1-3개의 저급알킬기를 나타내고 X1,X2및 X3는 서로 같거나 다른 할로겐원자를 나타낸다.Wherein R 1 represents a halogen atom, R 2 represents a hydrogen atom, a halogen, an amino group or a lower alkyl group having 1 to 3 carbon atoms, and X 1 , X 2 and X 3 represent the same or different halogen atoms. 다음 일반식(Ⅳ)의 화합물에 2-이미노-1-프로판올을 반응시켜서 제조된 다음 일반구조식(Ⅴ)의 화합물을 강염기의 존재하에 고리화반응을 행하여 다음 일반구조식(Ⅳ)의 화합물을 제조하고 이 화합물을 통상의 할로겐화반응을 행하여 다음 일반구조식(Ⅶ)의 화합물을 제조한 후 이 화합물을 통상의 가수분해반응을 행하여 다음 일반구조식(Ⅰ)의 화합물을 제조한다.Prepared by reacting 2-imino-1-propanol with a compound of formula (IV), and then cyclizing the compound of formula (V) in the presence of a strong base to prepare a compound of formula (IV) This compound is subjected to a conventional halogenation reaction to produce a compound of the following general structural formula (VII), and then subjected to a normal hydrolysis reaction of this compound to produce a compound of the following general structural formula (I). 상기식 중에서 R1은 할로겐원자, R2는 수소원자, 할로겐원자, 아미노기 또는 탄소수 1-3개의 저급알킬기를 나타내고 X1,X2및 X3는 서로 같거나 다른 할로겐원자를 나타낸다.Wherein R 1 represents a halogen atom, R 2 represents a hydrogen atom, a halogen atom, an amino group or a lower alkyl group having 1 to 3 carbon atoms, and X 1 , X 2 and X 3 represent the same or different halogen atoms. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940017883A 1994-07-23 1994-07-23 Quinolone carboxylic acid derivatives and preparation method thereof KR960004325A (en)

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KR1019940017883A KR960004325A (en) 1994-07-23 1994-07-23 Quinolone carboxylic acid derivatives and preparation method thereof

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Application Number Priority Date Filing Date Title
KR1019940017883A KR960004325A (en) 1994-07-23 1994-07-23 Quinolone carboxylic acid derivatives and preparation method thereof

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KR960004325A true KR960004325A (en) 1996-02-23

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