KR960001128A - Aminopeptides M inhibitor, preparation method thereof and microorganism producing the same - Google Patents

Aminopeptides M inhibitor, preparation method thereof and microorganism producing the same Download PDF

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Publication number
KR960001128A
KR960001128A KR1019940012837A KR19940012837A KR960001128A KR 960001128 A KR960001128 A KR 960001128A KR 1019940012837 A KR1019940012837 A KR 1019940012837A KR 19940012837 A KR19940012837 A KR 19940012837A KR 960001128 A KR960001128 A KR 960001128A
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South Korea
Prior art keywords
aminopeptides
inhibitor
preparation
same
microorganism producing
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KR1019940012837A
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Korean (ko)
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KR0122427B1 (en
Inventor
이충환
고학룡
고영희
전효곤
정명철
이호재
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김은영
한국과학기술연구원
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Priority to KR1019940012837A priority Critical patent/KR0122427B1/en
Publication of KR960001128A publication Critical patent/KR960001128A/en
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Publication of KR0122427B1 publication Critical patent/KR0122427B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 아미노펩티데이스 M 저해물질, 그를 생성하는 미생물 및 상기 물질의 제조방법에 관한 것이다. 본 발명에 의해 강한 아미노펩티데이스 M 저해활성 및 면역증강활성을 나타내는 신규한 물질인 발리스타틴을 미생물 스트렙토마이세스 속 20209 균주(KCTC 0103BP)를 배양하여 그 배양액으로부터 분리 정제할 수 있다.The present invention relates to aminopeptides M inhibitors, microorganisms that produce them, and methods of making such materials. According to the present invention, ballistastatin, a novel substance showing strong aminopeptides M inhibitory activity and immuno-enhancing activity, can be isolated and purified from the culture medium by culturing 20209 strain of microorganism Streptomyces (KCTC 0103BP).

Description

아미노펩티데이스 M 저해물질, 그의 제조방법 및 그를 생성하는 미생물Aminopeptides M inhibitor, preparation method thereof and microorganism producing the same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제1도는 본 발명의 아미노펩티데이스 M 저해물질인 발리스타틴의 메탄올중에서의 자외선 및 가시광선의 흡광도를 도시한 것이다.FIG. 1 shows the absorbance of ultraviolet and visible light in methanol of ballistatin, the aminopeptides M inhibitor of the present invention.

제2도는 발리스타틴(브롬화칼슘내)의 적외선 흡수 스펙트럼을 도시한 것이다.2 shows the infrared absorption spectrum of ballistatin (in calcium bromide).

제3도는 발리스타틴의 중메탄올 내에서 측정한 수소핵자기공명 스펙트럼(300MHz)이다.3 is the hydrogen nuclear magnetic resonance spectrum (300 MHz) measured in the heavy methanol of ballastin.

Claims (4)

하기 구조식을 갖는 아미노펩티데이스 M 저해물질 발리스타틴 또는 그의 염:Aminopeptides M inhibitor ballastin or a salt thereof having the structure: 제1항의 아미노펩티데이스 M 저해물질 발리스타틴을 생성하는 스트렙토마이세스 속 미생물.Microorganism of the genus Streptomyces to produce the aminopeptides M inhibitor ballistatin of claim 1. 제2항에 있어서, 스트렙토마이세스속(Streptomyces sp.)20209 균주(기탁번호 KCTC 0103BP).The strain Streptomyces sp. 20209 according to claim 2 (Accession No. KCTC 0103BP). 제2항 또는 제3항의 미생물을 배향하여 그 배양액으로부터 분리, 정제함을 특징으로 하는, 제1항의 아미노펩티데이스 M 저해물질 발리스타틴의 제조방법.A method for producing the aminopeptides M inhibitor Valistastatin according to claim 1, wherein the microorganism of claim 2 or 3 is oriented to separate and purify from the culture medium. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940012837A 1994-06-08 1994-06-08 Aminopeptidase m inhibitor, process for the preparation thereof and microorganism producing the same KR0122427B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940012837A KR0122427B1 (en) 1994-06-08 1994-06-08 Aminopeptidase m inhibitor, process for the preparation thereof and microorganism producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940012837A KR0122427B1 (en) 1994-06-08 1994-06-08 Aminopeptidase m inhibitor, process for the preparation thereof and microorganism producing the same

Publications (2)

Publication Number Publication Date
KR960001128A true KR960001128A (en) 1996-01-25
KR0122427B1 KR0122427B1 (en) 1997-11-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940012837A KR0122427B1 (en) 1994-06-08 1994-06-08 Aminopeptidase m inhibitor, process for the preparation thereof and microorganism producing the same

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KR0122427B1 (en) 1997-11-24

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