KR960001128A - Aminopeptides M inhibitor, preparation method thereof and microorganism producing the same - Google Patents
Aminopeptides M inhibitor, preparation method thereof and microorganism producing the same Download PDFInfo
- Publication number
- KR960001128A KR960001128A KR1019940012837A KR19940012837A KR960001128A KR 960001128 A KR960001128 A KR 960001128A KR 1019940012837 A KR1019940012837 A KR 1019940012837A KR 19940012837 A KR19940012837 A KR 19940012837A KR 960001128 A KR960001128 A KR 960001128A
- Authority
- KR
- South Korea
- Prior art keywords
- aminopeptides
- inhibitor
- preparation
- same
- microorganism producing
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
본 발명은 아미노펩티데이스 M 저해물질, 그를 생성하는 미생물 및 상기 물질의 제조방법에 관한 것이다. 본 발명에 의해 강한 아미노펩티데이스 M 저해활성 및 면역증강활성을 나타내는 신규한 물질인 발리스타틴을 미생물 스트렙토마이세스 속 20209 균주(KCTC 0103BP)를 배양하여 그 배양액으로부터 분리 정제할 수 있다.The present invention relates to aminopeptides M inhibitors, microorganisms that produce them, and methods of making such materials. According to the present invention, ballistastatin, a novel substance showing strong aminopeptides M inhibitory activity and immuno-enhancing activity, can be isolated and purified from the culture medium by culturing 20209 strain of microorganism Streptomyces (KCTC 0103BP).
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.
제1도는 본 발명의 아미노펩티데이스 M 저해물질인 발리스타틴의 메탄올중에서의 자외선 및 가시광선의 흡광도를 도시한 것이다.FIG. 1 shows the absorbance of ultraviolet and visible light in methanol of ballistatin, the aminopeptides M inhibitor of the present invention.
제2도는 발리스타틴(브롬화칼슘내)의 적외선 흡수 스펙트럼을 도시한 것이다.2 shows the infrared absorption spectrum of ballistatin (in calcium bromide).
제3도는 발리스타틴의 중메탄올 내에서 측정한 수소핵자기공명 스펙트럼(300MHz)이다.3 is the hydrogen nuclear magnetic resonance spectrum (300 MHz) measured in the heavy methanol of ballastin.
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940012837A KR0122427B1 (en) | 1994-06-08 | 1994-06-08 | Aminopeptidase m inhibitor, process for the preparation thereof and microorganism producing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940012837A KR0122427B1 (en) | 1994-06-08 | 1994-06-08 | Aminopeptidase m inhibitor, process for the preparation thereof and microorganism producing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960001128A true KR960001128A (en) | 1996-01-25 |
KR0122427B1 KR0122427B1 (en) | 1997-11-24 |
Family
ID=19384864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019940012837A KR0122427B1 (en) | 1994-06-08 | 1994-06-08 | Aminopeptidase m inhibitor, process for the preparation thereof and microorganism producing the same |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR0122427B1 (en) |
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1994
- 1994-06-08 KR KR1019940012837A patent/KR0122427B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR0122427B1 (en) | 1997-11-24 |
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