KR950703537A - 피리미딘 유도체(pyrimidine derivative) - Google Patents
피리미딘 유도체(pyrimidine derivative) Download PDFInfo
- Publication number
- KR950703537A KR950703537A KR1019950701455A KR19950701455A KR950703537A KR 950703537 A KR950703537 A KR 950703537A KR 1019950701455 A KR1019950701455 A KR 1019950701455A KR 19950701455 A KR19950701455 A KR 19950701455A KR 950703537 A KR950703537 A KR 950703537A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- phenyl
- alkenyl
- alkynyl
- cycloalkyl
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 43
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 42
- 239000001257 hydrogen Substances 0.000 claims abstract 42
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 40
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 36
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 35
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 34
- 150000002431 hydrogen Chemical class 0.000 claims abstract 30
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 12
- 229910052736 halogen Inorganic materials 0.000 claims abstract 12
- 150000002367 halogens Chemical class 0.000 claims abstract 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 9
- 150000003230 pyrimidines Chemical class 0.000 claims abstract 8
- 125000000714 pyrimidinyl group Chemical group 0.000 claims abstract 5
- 125000004122 cyclic group Chemical group 0.000 claims abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 4
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract 3
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 claims abstract 3
- 125000003003 spiro group Chemical group 0.000 claims abstract 2
- 125000000464 thioxo group Chemical group S=* 0.000 claims abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 230000002363 herbicidal effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
- A01N57/24—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing heterocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
- C07D239/40—One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
본 발명은 제초활성 및 살진균 활성을 갖는 하기 일반식(I)의 피리미딘 유도체에 관한 것이다.:
[식중, R1및 R2는 각각 독립적으로 수소:알킬:알케닐:알키닐:페닐:시아노:COOR9:할로겐:OR10:SR11:OCOR12:아미노, Z1P=(=Z2)(Z3R13)(Z4R14), 또는 이들은 함께 옥소, 티옥소, 시클릭 케탈 또는 시클릭 티오케탈, =CR15R16:NR17:NNR18R19:NOR20:또는 하기로 구성된 군으로부터 선택된 스피로 고리를 형성하고;
R3및 R5는 각각 독립적으로 수소:할로겐:알킬:알케닐:알키닐:페닐:시클로알킬:S(O)mR21:NR22:R23:NR24NR25R26:OR27:시아노:COOR28:CONR29R30:PZ5(OR31)(OR32)이고:R4는 수소:할로겐:아미노:시아노:아미노:알킬:알케닐:알키닐:페닐:시클로알킬:COOR33:COR34:CONR35R36:OR37:S(O)pR38이지만, R4가 수소일 경우, R3및 R5는 상이하며 R4는 R3또는 R5및 피리미딘 고리와 결합하여 하기 일반식중의 하나로 나타내는 축합 고리를 형성하며
R6및 R7은 각각 독립적으로 수소:할로겐:알킬:알케닐:알키닐:페닐:시클로알킬:S(O)rR39:OR40:COOR41:CONR42R43:아미노:니트로 또는 시아노이고, 단, R6및 R7은 동시에 수소가 아니며, R8은 각각 동일하거나 상이할 수 있으며, 할로겐;알킬:알케닐:알키닐;페닐:시클로알킬:S(O)tR44:OR45:COOR46:CONR42R43:아미노:니트로 또는 시아노이고;n은 0, 1, 2 또는 3의 정수이며, 단, R1및 R2가 모두 수소일 경우 R4는 R3또는 R5및 피리미딘 고리와 결합하여 상술한 축합고리를 형성한다.]
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 하기 일반식(I)의 피리미딘 유도체 및 그의 염;[식중, R1및 R2는 각각 독립적으로 수소;알킬;알케닐:알키닐:페닐:시아노:COOR9(식중, R9는 수소 또는 알킬이다):할로겐:OR10(식중, R10는 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):SR11(식중, R11는 수소, 알킬, 알케닐, 페닐 또는 시클로알킬이다):OCOR12(식중 R12는 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):아미노, Z1P=(=Z2)(Z3R13)(Z4R14)(식중, R13및 R14는 각각 독립적으로 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이고, Z1, Z2, Z3및 Z4는 각각 독립적으로 O 또는 S이다)이거나, 함께 옥소, 티옥소, 시클릭 케탈 또는 시클릭 티오케탈, =CR15R16(식중, R15및 R16은 각각 독립적으로 수소, 니트릴, 시아노, 알킬, 알케닐, 알키닐, 알킬카르보닐, 카르바모일, 카르복시, 알콕시카르보닐, 알케닐옥시카르보닐, 알키닐옥시카르보닐, 페닐, 알킬술포닐 또는 페닐술포닐이다), =NR17(식중, R17은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다), =NNR18(식중, R18및 R19는 각각 독립적으로 수소, 알킬, 알케닐, 알키닐, 페닐, 시클로알킬, 알콕시카르보닐 또는 카르복시이다), =NOR20(식중, R20은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다), 또는 하기로 구성된 군으로부터 선택된 스피로 고리를 형성하고;R3및 R5는 각각 독립적으로 수소:할로겐:알킬:알케닐:알키닐:페닐:시클로알킬:S(O)mR21(식중, R21은 수소, 알킬,알케닐, 알키닐, 페닐 또는 시클로알킬이고 m은 0,1 또는 2의 정수이다):NR22R23(식중, R22및 R23은 각각 독립적으로 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이거나 함께 고리를 형성할 수 있다):NR24NR25R26(식중, R24, R25및 R26은 각각 독립적으로 수소, 알킬, 알콕시카르보닐 또는 페닐이다):OR27(식중, R27은 수소,알킬,알케닐,페닐 또는 시클로알킬이다):시아노:COOR28(식중, R28은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):CONR29R30(식중, R29및 R30은 각각 독립적으로 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):CONR29R30(식중, R29및 R30은 각각 독립적으로 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):PZ5(OR31)(OR32)(식중, Z5는 O 또는 S이고, R31및 R32는 동일하거나 상이할 수 있으며 알킬 또는 페닐이다)이고:R4는 수소:할로겐:아미노:시아노:알킬:알케닐:알키닐:페닐:시클로알킬:COOR33(식중, R33은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):COR34(식중, R34은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):CONR35R36(식중, R35및 R36은 각각 독립적으로 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):OR37(식중, R37은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):S(O)pR38(식중, R38은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이고 p는 0,1 또는 2의 정수이다)이지만, R4가 수소일 경우, R3및 R5는 상이하며 R4는 R3또는 R5및 피리미딘 고리와 결합하여 하기 일반식중의 하나로 나타내는 축합 고리를 형성하며;[식중, A, B, C, D 및 E는 각각,O,S(O)q 또는를 나타내며, 나머지는를 나타낸다(상기에서, r1, r2및 r3는 각각 독립적으로 수소, 할로겐, 알킬, 페닐, 알킬카르보닐, 페닐카르보닐 또는 알콕시카르보닐이거나 인접 r1또는 r3와 결합하여 이중결합을 형성할 수 있고, q는 0, 1 또는 2의 정수이다)]; R6및 R7은 독립적으로 수소;할로겐;알킬;알케닐;알키닐;페닐;시클로알킬;S(O)rR39(식중, R39은 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이고 r은 0,1 또는 2의 정수이다):OR40(식중, R30은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):COOR41(식중, R41은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):CONR42R43(식중, R42및 R43은 각각 독립적으로 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):아미노:니트로 또는 시아노이고, 단, R6및 R7은 동시에 수소가 아니며; R8은 각각 동일하거나 상이할 수 있으며, 할로겐:알킬:알케닐:알키닐:페닐:시클로알킬:S(O)tR44(식중, R44은 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이고 t는 0, 1 또는 2의 정수이다):OR45(식중, R45은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):COOR46(R46은 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):CONR42R43(식중, R42및 R43은 각각 독립적으로 수소, 알킬, 알케닐, 알키닐, 페닐 또는 시클로알킬이다):아미노:니트로 또는 시아노이고; n은 0, 1, 2 또는 3의 정수이며, 단, R1및 R2가 모두 수소일 경우 R4는 R3또는 R5및 피리미딘 고리와 결합하여 상술한 축합고리를 형성한다.]
- 제1항에 있어서, 축합고리가 하기와 같은 피리미딘 유도체;[식중, R3,R5, r1, r2, r3및 q는 상기 정의한 바와 같다]
- 제1항 또는 제2항에 있어서, R1또는 R2가 히드록시 또는 할로겐이거나, R1및 R2가 함께 옥소기를 형성하는 피리미딘 유도체.
- 제1항 또는 제2항에 있어서, R15또는 R16이 카르바모일 또는 알콜시카르보닐인 피리미딘 유도체.
- 제1항 또는 제2항에 있어서, R17이 하기 기로 치환된 알킬인 피리미딘 유도체.
- 제1항 또는 제2항에 있어서, R3가 할로알킬 또는 측쇄 알킬인 피리미딘 유도체.
- 활성 성분으로서 하기 일반식(I)의 1종이상의 피리미딘 유도체를 함유하는 제조제;[식중, R1, R2, R3, R4, R5, R6, R7, R8및 n은 상기 정의한 바와 같다]
- 활성 성분으로서 하기 일반식(I)의 1종이상의 피리미딘 유도체를 함유하는 농경용 및 원예용 살진균제;[식중, R1, R2, R3, R4, R5, R6, R7, R8및 n은 상기 정의한 바와 같다]※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP92-304622 | 1992-10-16 | ||
JP30462292 | 1992-10-16 | ||
JP15430393 | 1993-06-01 | ||
JP93-154303 | 1993-06-01 | ||
PCT/JP1993/001478 WO1994008975A1 (en) | 1992-10-16 | 1993-10-14 | Pyrimidine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
KR950703537A true KR950703537A (ko) | 1995-09-20 |
Family
ID=26482630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950701455A KR950703537A (ko) | 1992-10-16 | 1993-10-14 | 피리미딘 유도체(pyrimidine derivative) |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0665224A1 (ko) |
KR (1) | KR950703537A (ko) |
AU (1) | AU5161193A (ko) |
BR (1) | BR9307264A (ko) |
CA (1) | CA2147275A1 (ko) |
WO (1) | WO1994008975A1 (ko) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0754684A4 (en) * | 1994-04-01 | 1998-05-13 | Shionogi & Co | OXIME DERIVATIVES AND BACTERICIDE CONTAINING IT AS ACTIVE INGREDIENTS |
US6268312B1 (en) | 1994-04-01 | 2001-07-31 | Shionogi & Co., Ltd. | Oxime derivative and bactericide containing the same as active ingredient |
HUP0002239A3 (en) * | 1997-05-08 | 2002-08-28 | Agrevo Uk Ltd Hauxton | The use of thienopyrimidine derivatives for combating fungi |
US7229993B2 (en) | 2002-03-13 | 2007-06-12 | Euro-Celtique S.A. | Aryl substituted pyrimidines and the use thereof |
JP2004137270A (ja) * | 2002-09-26 | 2004-05-13 | Nippon Nohyaku Co Ltd | 新規除草剤、その使用方法、新規置換チエノピリミジン誘導体及びその中間体並びにそれらの製造方法 |
AR044743A1 (es) * | 2002-09-26 | 2005-10-05 | Nihon Nohyaku Co Ltd | Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos, |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
US6818631B1 (en) | 2003-08-15 | 2004-11-16 | Nippon Soda Co. Ltd. | Fungicidal pyrimidine derivatives |
BRPI0514857A (pt) | 2004-09-03 | 2008-05-06 | Celgene Corp | composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função de vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central |
CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
WO2008092199A1 (en) * | 2007-01-31 | 2008-08-07 | Cytopia Research Pty Ltd | Thiopyrimidine-based compounds and uses thereof |
TW200922587A (en) * | 2007-09-25 | 2009-06-01 | Actimis Pharmaceuticals Inc | Alkylthio pyrimidines as CRTH2 antagonists |
JP2012162460A (ja) * | 2009-05-27 | 2012-08-30 | Nippon Soda Co Ltd | 含窒素ヘテロアリール誘導体および農園芸用殺菌剤 |
CN105732639A (zh) | 2012-06-29 | 2016-07-06 | 辉瑞大药厂 | 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 |
EP3083618B1 (en) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
PL3094631T3 (pl) | 2014-01-16 | 2019-07-31 | Fmc Corporation | Pochodne pirymidynyloksy-benzenu jako środki chwastobójcze |
AR101264A1 (es) * | 2014-07-25 | 2016-12-07 | Du Pont | Piridonas como herbicidas |
MX2017009792A (es) | 2015-03-18 | 2017-10-27 | Du Pont | Derivados de pirimidiniloxipiridina sustituidos como herbicidas. |
TW202400564A (zh) | 2015-06-05 | 2024-01-01 | 美商艾佛艾姆希公司 | 作為除草劑之嘧啶氧基苯衍生物 |
CA2990839A1 (en) | 2015-07-13 | 2017-01-19 | E.I. Du Pont De Nemours & Company | Aryloxypyrimidinyl ethers as herbicides |
JP6873980B2 (ja) | 2015-09-14 | 2021-05-19 | ファイザー・インク | LRRK2阻害薬としての新規のイミダゾ[4,5−c]キノリンおよびイミダゾ[4,5−c][1,5]ナフチリジン誘導体 |
SG11201804901WA (en) | 2015-12-22 | 2018-07-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
US11427549B2 (en) | 2017-05-02 | 2022-08-30 | Fmc Corporation | Pyrimidinyloxy benzo-fused compounds as herbicides |
CA3066939A1 (en) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
EP4026833A1 (de) * | 2021-01-12 | 2022-07-13 | Bayer Aktiengesellschaft | Herbizid wirksame 2-(het)arylmethylpyrimidine |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3546212A (en) * | 1968-06-12 | 1970-12-08 | Hoffmann La Roche | Oxidation of benzodiazepines with ruthenium tetroxide |
GB8917222D0 (en) * | 1989-07-27 | 1989-09-13 | Schering Agrochemicals Ltd | Herbicides |
HU212435B (en) * | 1990-06-07 | 1996-06-28 | Sandoz Ag | Herbicidal compositions containing substituted phthalides and heterocyclic phthalides as active ingredient and process for preparation of their active ingredients. |
HU9203730D0 (en) * | 1991-12-06 | 1993-03-29 | Sandoz Ag | Substituted phthalides and heterocyclic ones |
JPH0649039A (ja) * | 1992-06-04 | 1994-02-22 | Nippon Soda Co Ltd | ピリミジン誘導体、除草剤および農園芸用殺菌剤 |
-
1993
- 1993-10-14 KR KR1019950701455A patent/KR950703537A/ko not_active Application Discontinuation
- 1993-10-14 WO PCT/JP1993/001478 patent/WO1994008975A1/ja not_active Application Discontinuation
- 1993-10-14 EP EP93922632A patent/EP0665224A1/en not_active Withdrawn
- 1993-10-14 CA CA002147275A patent/CA2147275A1/en not_active Abandoned
- 1993-10-14 AU AU51611/93A patent/AU5161193A/en not_active Abandoned
- 1993-10-14 BR BR9307264A patent/BR9307264A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0665224A1 (en) | 1995-08-02 |
WO1994008975A1 (en) | 1994-04-28 |
EP0665224A4 (en) | 1995-06-13 |
BR9307264A (pt) | 1999-05-11 |
CA2147275A1 (en) | 1994-04-28 |
AU5161193A (en) | 1994-05-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR950703537A (ko) | 피리미딘 유도체(pyrimidine derivative) | |
EP1974606A3 (de) | Selektive Insektizide auf Basis von Phthalsäurediamiden und Safenern | |
RU95101836A (ru) | Производные 1н-3-арил-пирролидин-2,4-диона, смесь их изомеров или отдельные изомеры и средство для борьбы с вредителями | |
GB0206860D0 (en) | Compounds | |
BR0013367A (pt) | Uso de compostos, composição pesticida, e, método de combate a pestes em um local infestado ou sujeito a ser infestado com as mesmas | |
BR9103540A (pt) | Composto,composicao pesticida e processos para controlar pragas e para preparar um composto | |
MX9204006A (es) | Derivados de la 3-aril-4-hidroxi-delta3-dihidrofuranona y de la 3-aril-4-hidroxi-delta3-dihidrotiofenona y procedimiento para su obtencion. | |
PT718293E (pt) | Composto ciclodepsipeptidico | |
ES2173088T3 (es) | Derivados de n-arilhidrazina utiles como agentes insecticidas y acaricidas. | |
BRPI0406875A (pt) | Derivados de monossacarìdeo de avermectina tendo propriedades pesticidas | |
EA199900601A1 (ru) | Производные циклогександиона и содержащие их гербициды | |
ES2119919T3 (es) | Derivados de dihidrobenzofurano, su preparacion y su utilizacion. | |
ATE161837T1 (de) | Benzopyran derivat, seine darstellung und pharmazeutische zusammensetzung, welche dieses enthält | |
WO1998051152A1 (fr) | Insecticides/acaricides | |
UA39893C2 (uk) | Суміш з гербіцидів та антидотів та спосіб захисту культурних рослин | |
KR927003553A (ko) | 알알킬옥시아민 유도체 및 제초제 조성물 | |
TW366259B (en) | N-arylthiohydrazone derivatives as insecticidal and acaricidal agents | |
AR001113A1 (es) | 1-alqueniltetrazolinonas un procedimiento para su preparación composiciones herbicidas y procedimientos para su preparación procedimiento para combatir malas hierbas y compuestos intermediarios | |
EP1026159A4 (en) | 4-ARYL-4- SUBSTITUTED PYRAZOLIDINE-3,5-DIONE DERIVATIVES | |
KR960704867A (ko) | 신규한 1,3-옥사진-4-온 유도체, 그를 함유한 제초제 및 그의 제조용 중간물질 (novel 1,3-oxazin-4-one derivatives, herbicides containing the same, and intermediates for preparing the same) | |
GB1173208A (en) | Urea Derivatives and their use as Herbicides | |
ATE112776T1 (de) | Von milbemycinen ableitbare insektizide und parasitizide. | |
IE33893L (en) | Insecticidal agents; substituted benzene derivatives | |
KR910014387A (ko) | 디티오피로포스페이트와 살충제로서의 그의 용도 | |
KR930021607A (ko) | 히드라존 유도체, 그의 제조 방법, 활성 성분으로서 이를 함유하는 살충제 및/또는 살진드기제, 및 그의 중간체 화합물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |