KR950024764A - Alcoholic Disorder Protectors And How To Use Him - Google Patents

Alcoholic Disorder Protectors And How To Use Him Download PDF

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KR950024764A
KR950024764A KR1019940002939A KR19940002939A KR950024764A KR 950024764 A KR950024764 A KR 950024764A KR 1019940002939 A KR1019940002939 A KR 1019940002939A KR 19940002939 A KR19940002939 A KR 19940002939A KR 950024764 A KR950024764 A KR 950024764A
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alcoholic
vit
disorder
alcohol
oil
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강상모
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/70—Vitamins
    • A23V2250/704—Vitamin B
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/70—Vitamins
    • A23V2250/712—Vitamin E

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  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

알콜의 대사경로는 위장관 또는 간에 존재하는 알콜 디하이드로게나제(alcohol dehydrogenase, 이하 ADH라 칭함)의 작용, 소포체에 존재하는 마이크로조말 에탄올 산화 복합체(microsomal ethanol oxidizing system, 이하 MEOS라 칭함)작용, 퍼옥시좀(peroxysome)에 존재하는 카탈라제(catalase)의 작용 등을 거쳐 이산화 탄소(CO2)와 물(H2O)로 분해된다.Metabolic pathways of alcohol include the action of alcohol dehydrogenase (hereinafter referred to as ADH) present in the gastrointestinal tract or liver, the microsomal ethanol oxidizing system (hereinafter referred to as MEOS) present in the endoplasmic reticulum, fur It is decomposed into carbon dioxide (CO 2 ) and water (H 2 O) through the action of catalase present in the oxysome (peroxysome).

간이나 위에 존재하는 ADH는 알콜과의 높은 친화력 때문에 알콜 유입시 가장 중요한 역할을 담당하는 효소이지만, 과량의 알콜 유입시에는 과도한 부하가 생성되어 그 작용이 원활하게 일어나지 못하고 대신 알콜에 대한 낮은 친화력을 가지고 있는 소포체의 MEOS가 알콜 신화에 대한 주요한 경로로서 작용한다. 그러나 이러한 체계를 이용하는 알콜 분해는 인체내 독성 작용을 나타내는 다량의 활성산소를 발생시키기 때문에 그것으로 인한 세포손상이 숙취의 주요 원인으로 생각된다.ADH, which is present in the liver or stomach, is the enzyme that plays the most important role in the influx of alcohol due to its high affinity with alcohol, but excessive influx produces excessive loads, which does not occur smoothly. Instead, it has a low affinity for alcohol. MEOS of the endoplasmic reticulum has a major route to alcohol mythology. However, alcohol degradation using this system generates a large amount of free radicals that show toxic effects in the human body, and thus cell damage is considered to be a major cause of hangover.

종래의 대부분의 알콜관련 연구는 간을 중심으로한 알콜분해 효소들에 많은 관심을 가졌으며, 최근들어 알콜 섭취로 활성산소가 발생한다는 논문이 발표되기 시작하였으나, 최근 국제학계에서 노화방지, 암예방으로 속속들이 발표되는 카로틴, 노화방지로 유명한 비타민 E(vitamin E, 이하 Vit-E라 함), 피로 회복제로 유명한 비타민 C(vitamin C, 이하 Vit-C라 함)등을 비교적 과량 투여함으로 숙취 및 알콜성 설사를 제거할 수 있다는 방안은 전혀 강구되어 있지 않았다. 카로틴, Vit-E, Vit-C 등의 항산화제의 비교적 과량이 투여에 의한 숙취제거 효과는 다음과 같이 생각한다. 알콜을 산화 시키는데 주로 사용되는 MEOS에서는 활성산소가 생기며, 미토콘드리아에서도 생기는데 이 때 생긴 활성산소는 체내에 존재하는 슈퍼옥사이드 디스뮤타제(superoxide dismutase, SOD)에 의하여 과산화수소가 된다. 이것은 다시 카타라제(catalase)에 의하여 물과 산소로 되는데, 어느 정도 이상의 알콜을 마시면 과잉의 활성산소가 발생하게 되어 SOD가 모자라게 되고 미처 무독화되지 못한 활성산소에 의하여 세포성분들이 파괴되고 이로 인하여 숙취가 초래되는 것으로 본다. 따라서 이러한 가정하에 항산화제로 유명한 카로틴, Vit-E, Vit-C를 젊은 청년들 중 평소 숙취를 느끼는 사람들만 선별하여 주량 최도로 소주와 맥주를 음용시켜 두통 편두통 등의 숙취를 조사하였던 바, 카로틴의 경우는 85%, Vit-E는 90%, Vit-C는 75%가 두통을 느끼지 않게 되었다. 뿐만아니라 알콜성 설사의 경우도 이들 실험에서 상단히 호전되었는데 그 효과는 Vit-E, 카로틴, Vit-C순이며, 그외 비타민과 아미노산이 이들의 효과를 증진시켜준다.Most of the previous researches on alcohol have been focused on alcohol-degrading enzymes centered on the liver, and recently, a study on the generation of free radicals by alcohol consumption has been published, but recently in international studies, anti-aging and cancer prevention Carotene, which is widely released in the body, and vitamin E (vitamin E), also known as anti-aging, and vitamin C (vitamin C, also known as Vit-C), a fatigue-relieving agent. There was no way to eliminate sexual diarrhea. The hangover removal effect by the administration of comparatively excessive dose of antioxidants, such as carotene, Vit-E, Vit-C, is considered as follows. In MEOS, which is mainly used to oxidize alcohols, free radicals are generated in mitochondria, and the free radicals are hydrogen peroxide caused by superoxide dismutase (SOD) in the body. It is converted into water and oxygen by catalase, and drinking more alcohol produces excess free radicals, which leads to a lack of SOD, which destroys cellular components by detoxifying free radicals. Seems to be caused. Therefore, under these assumptions, carotene, Vit-E, and Vit-C, which are famous for antioxidants, were selected only among young people who had a hangover and drinking alcoholic beverages and beer at the highest level to investigate hangovers such as headache migraine. In 85% of cases, 90% of Vit-E and 75% of Vit-C had no headache. In addition, alcoholic diarrhea also improved dramatically in these experiments, followed by Vit-E, carotene, and Vit-C, and other vitamins and amino acids enhance their effectiveness.

Description

알콜성 장애 보호제 및 그를 이용하는 방법Alcoholic Disorder Protectors And How To Use Them

제1도는 활성산소의 생성과정과 방어기작,Figure 1 shows the process of formation and defense mechanism of free radicals,

제2도는 급성 제1차 알콜투여에 의한 졸도시간,FIG. 2 shows fainting time due to acute primary alcohol administration,

제3도는 급성 제2차 알콜투여에 의한 졸도시간,FIG. 3 shows fainting time due to acute secondary alcohol administration,

제4도는 급성 제1차 알콜투여에 의한 혈청 중 LDH의 변화.4 shows changes in LDH in serum by acute primary alcohol administration.

Claims (25)

카로틴, Vit-E, Vit-C중 1종 또는 2종 이상 조성물을 유효성분으로 하거나, 여기에 기타 비타민과 아미노산이 첨가된 것임을 특징으로 하는 알콜성 장애 보호제.An alcoholic disorder protective agent, characterized in that one or two or more compositions of carotene, Vit-E, and Vit-C are used as active ingredients, or other vitamins and amino acids are added thereto. 제1항에 있어서, 조성물은 인체체중(㎏)당 카로틴을0.0001-0.4g/㎏, Vit-E를 0.00025-0.4g/㎏, Vit-C를 0.0017-0.4g/㎏의 양으로 사용됨을 특징으로 하는 알콜성 장애 보호제.According to claim 1, wherein the composition is used in the amount of carotene 0.0001-0.4g / kg, Vit-E 0.00025-0.4g / kg, Vit-C 0.0017-0.4g / kg per body weight (kg) Alcoholic disorder protective agent. 제1항에 있어서, 알콜성 장해는 알콜성 간 기능 저해방지 또는 알콜성 간조직 손상보호 또는 알콘성 두통, 편두통, 나른함 등의 숙취 또는 알콜성 설사 또는 알콜성 정신장해 임을 특징으로 하는 알콜성 장애 보호제.The alcoholic disorder of claim 1, wherein the alcoholic disorder is an alcoholic liver disorder prevention or alcoholic liver tissue damage protection or a hangover or alcoholic diarrhea or alcoholic mental disorder such as an alcoholic headache, migraine or drowsiness. Protectant. 제1항에 있어서, 조성물을 물, 전분류, 유화제류, 탄산수, 당류, 소금, 스프류, 육류, 아미노산, 과실류, 채소류, 곡류, 해조류, 한약제류, 약용식물류, 식용유류, 오일류, 유기산, 항산화제, 기타 비타민류, 씨앗, 술로부터 선택된 1종 또는 2종 이상과 함께 함유하여 이용할 수 있음을 특징으로 하는 알콜성 장애 보호제.The composition of claim 1, wherein the composition comprises water, starch, emulsifiers, carbonated water, sugars, salts, soups, meat, amino acids, fruits, vegetables, grains, seaweeds, herbal medicines, medicinal plants, edible oils, oils, organic acids, An alcoholic disorder protective agent, characterized in that it can be used in combination with one or two or more selected from antioxidants, other vitamins, seeds, alcohol. 제4항에 있어서, 당류는 단당류, 이당류, 다당류, 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder protective agent according to claim 4, wherein the saccharide is monosaccharide, disaccharide, polysaccharide, or saccharide. 제4항에 있어서, 육류는 쇠고기, 돼지고기, 양고기, 또는 닭고기 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder protector according to claim 4, wherein the meat is beef, pork, lamb, or chicken. 제4항에 있어서, 아미노산은 이소루이신, 루이신, 티로신, 발린, 트립토판 또는 타우린 임을 특징으로 하는 알콜성 장애.5. The alcoholic disorder of claim 4, wherein the amino acid is isoleucine, leucine, tyrosine, valine, tryptophan or taurine. 제4항에 있어서, 과실류는 배, 복숭아, 귤, 사과, 무화과, 파인애플, 오랜지, 자두, 감, 키위, 포도, 바나나, 레몬, 모과, 유자, 대추, 매실, 자몽 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder of claim 4, wherein the fruits are pears, peaches, tangerines, apples, figs, pineapples, oranges, plums, persimmons, kiwis, grapes, bananas, lemons, quince, citron, jujube, plum, and grapefruit. Protectant. 제4항에 있어서, 채소류는 아스파라거스, 박, 호박, 딸기, 상추, 마늘, 미나리, 양파, 시금치, 배추, 고추, 양배추, 당근, 부추, 숙주, 토마토, 생강, 메론, 오이, 생강, 콩나물, 깻잎, 피망, 감자, 고구마, 우엉, 가지 임을 특징으로 하는 알콜성 장애 보호제.The vegetable according to claim 4, wherein the vegetables are asparagus, gourd, pumpkin, strawberry, lettuce, garlic, buttercup, onion, spinach, cabbage, pepper, cabbage, carrot, leek, host, tomato, ginger, melon, cucumber, ginger, sprouts, Alcoholic disorder preventive agent characterized by sesame leaves, bell peppers, potatoes, sweet potatoes, burdock and eggplant. 제4항에 있어서, 곡류는 콩, 녹두콩, 강남콩, 땅콩, 참깨, 들깨, 옥수수, 아몬드 임을 특징으로 하는 알콜성 장애 보호제.The alcoholic disorder protector according to claim 4, wherein the grains are beans, mung beans, gangnan beans, peanuts, sesame seeds, perilla, corn, and almonds. 제4항에 있어서, 어류 및 해조류는 김, 미역, 다시마, 오징어, 또는 북어 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder protector according to claim 4, wherein the fish and seaweed are seaweed, seaweed, kelp, squid, or northern fish. 제4항에 있어서, 한약제류는 인삼, 가시오갈피, 감초, 계피, 건강, 진피, 장출 임을 특징으로 하는 알콜성 장애 보호제.According to claim 4, Chinese herbal medicines, ginseng, thorns of red peppers, licorice, cinnamon, health, dermis, enteric alcohol, characterized in that the protective agent for disorders. 제4항에 있어서, 약용식물류는 신선초, 케일, 알로에, 컴프리, 돌나물, 쑥, 익모초, 차조기, 솔잎 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder protector according to claim 4, wherein the medicinal plants are fresh vinegar, kale, aloe, comfrey, sedum, wormwood, motherwort, perilla and pine needles. 제4항에 있어서, 식용유류 및 오일류는 참기름, 들기름, 옥수수기름, 콩기름, 유채기름, 면실유, 올리브기름, 팜유, 돼지기름, 소기름, 닭고기기름, 생선기름 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder preventing agent according to claim 4, wherein the edible oils and oils are sesame oil, perilla oil, corn oil, soybean oil, rapeseed oil, cottonseed oil, olive oil, palm oil, pork oil, bovine oil, chicken oil and fish oil. 제4항에 있어서, 유기산은 구연산, 사과산, 호박산 또는 주석산 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder protector according to claim 4, wherein the organic acid is citric acid, malic acid, succinic acid or tartaric acid. 제4항에 있어서, 항산화제는 L - 메치오닌, 마니톨, 비타민 B12, BHT, BHA, 등의 항산화제와 셀레늄 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder protecting agent according to claim 4, wherein the antioxidant is selenium and antioxidants such as L-methionine, mannitol, vitamin B 12 , BHT, BHA, and the like. 제4항에 있어서, 비타민은 리보플라빈, 카르니틴, 피리독신, 치아민, 니코틴산, 이노시톨 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder protector according to claim 4, wherein the vitamin is riboflavin, carnitine, pyridoxine, chiamine, nicotinic acid, inositol. 제4항에 있어서, 씨앗은 해바라기씨, 호박씨, 달맞이꽃, 차조씨 임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder protector according to claim 4, wherein the seeds are sunflower seeds, pumpkin seeds, evening primrose, chajo seeds. 제1항에 있어서, 조성물이 0.01- 100중량%의 양으로 함유함을 특징으로 하는 알콜성 장애 보호제.2. The alcoholic disorder protector according to claim 1, wherein the composition contains in an amount of 0.01-100% by weight. 제19항에 있어서, 조성물이 0.01- 10중량%의 양으로 함유함을 특징으로 하는 액체형 알콜성 장애 보호제.20. The liquid alcoholic disorder protector according to claim 19, wherein the composition contains in an amount of 0.01-10% by weight. 제19항에 있어서, 조성물이 0.6 - 100중량%의 양으로 함유함을 특징으로 하는 고체 또는 분말형 알콜성 장애 보호제.20. The solid or powdered alcoholic disorder protector according to claim 19, wherein the composition contains in an amount of 0.6-100% by weight. 제1항에 있어서, 상기 보호제를 사람의 근육, 피하 또는 정맥에 주사에 이용됨을 특징으로 하는 알콜성 장애 보호제.2. An alcoholic disorder protective agent according to claim 1, wherein said protective agent is used for injection into a muscle, subcutaneous or vein of a human. 제4항에 있어서, 조성물은 카로틴이 0.01-10중량%, Vit-E가 0.02- 20중량%, Vit-C가 0.15-20중량%임을 특징으로 하는 알콜성 장애 보호제.5. The alcoholic disorder protector according to claim 4, wherein the composition is 0.01-10% by weight carotene, 0.02--20% by weight Vit-E and 0.15-20% by weight Vit-C. 술은 제조함에 있어서 알콜성 장애 보호를 할 수 있는 카로틴, Vit-C가 많은 야채 및 과일, Vit-E많은 곡류 및 씨앗 중, 1종 또는 2종 이상의 재료를 이용하는 방법.Alcohol is used in the production of carotene, Vit-C-rich vegetables and fruits, Vit-E-rich grains and seeds, which can provide alcoholic disorder protection in the production of one or two or more materials. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940002939A 1994-02-18 1994-02-18 Agents for alcoholic damage KR0131565B1 (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010044676A (en) * 2001-03-15 2001-06-05 김형식 Compositions for cleaning the liver
KR20020088734A (en) * 2001-05-21 2002-11-29 엄경용 Composition for dissolving suffer from aftereffects of drink
KR20030073498A (en) * 2002-03-12 2003-09-19 최승호 hangover annul material, its producing method and its vessel
KR100584891B1 (en) * 2004-08-13 2006-05-30 (주)씨스팜 Usage of gliadin-combined cantaloupe melon Cucumis melc LC extract, an orally effective SODsuperoxide dismutase, as anti-hangover agent
WO2007058505A1 (en) * 2005-11-21 2007-05-24 Gentro Co., Ltd. Hangover curing agent containing a raw unripe red pepper extract and health supporting foods containing the same
KR100789000B1 (en) * 2005-11-21 2007-12-28 주식회사 젠트로 Hangover curing agent containing a raw unripe red pepper extract and health supporting foods containing the same
KR20200074651A (en) * 2018-12-17 2020-06-25 한남대학교 산학협력단 Beverage composition for relieving hangover and manufacturing method thereof
KR102367717B1 (en) * 2020-12-04 2022-02-25 주식회사 코스팜 Food composition for relieving hangovers and improving a liver and food containing the same
WO2022080516A1 (en) * 2020-10-14 2022-04-21 농업회사법인제주황금꽃벵이주식회사 Composition for hangover relief and liver function improvement
WO2023153777A1 (en) * 2022-02-08 2023-08-17 한국 한의학 연구원 Composition for hangover relief comprising cucumis melo l. extract as active ingredient

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010044676A (en) * 2001-03-15 2001-06-05 김형식 Compositions for cleaning the liver
KR20020088734A (en) * 2001-05-21 2002-11-29 엄경용 Composition for dissolving suffer from aftereffects of drink
KR20030073498A (en) * 2002-03-12 2003-09-19 최승호 hangover annul material, its producing method and its vessel
KR100584891B1 (en) * 2004-08-13 2006-05-30 (주)씨스팜 Usage of gliadin-combined cantaloupe melon Cucumis melc LC extract, an orally effective SODsuperoxide dismutase, as anti-hangover agent
WO2007058505A1 (en) * 2005-11-21 2007-05-24 Gentro Co., Ltd. Hangover curing agent containing a raw unripe red pepper extract and health supporting foods containing the same
KR100789000B1 (en) * 2005-11-21 2007-12-28 주식회사 젠트로 Hangover curing agent containing a raw unripe red pepper extract and health supporting foods containing the same
KR20200074651A (en) * 2018-12-17 2020-06-25 한남대학교 산학협력단 Beverage composition for relieving hangover and manufacturing method thereof
WO2022080516A1 (en) * 2020-10-14 2022-04-21 농업회사법인제주황금꽃벵이주식회사 Composition for hangover relief and liver function improvement
KR102367717B1 (en) * 2020-12-04 2022-02-25 주식회사 코스팜 Food composition for relieving hangovers and improving a liver and food containing the same
WO2023153777A1 (en) * 2022-02-08 2023-08-17 한국 한의학 연구원 Composition for hangover relief comprising cucumis melo l. extract as active ingredient

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