KR950023418A - 정형외과용 세멘트 비드조성물 및 그의 제조방법 - Google Patents

정형외과용 세멘트 비드조성물 및 그의 제조방법

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Publication number
KR950023418A
KR950023418A KR1019940000382A KR19950000382A KR950023418A KR 950023418 A KR950023418 A KR 950023418A KR 1019940000382 A KR1019940000382 A KR 1019940000382A KR 19950000382 A KR19950000382 A KR 19950000382A KR 950023418 A KR950023418 A KR 950023418A
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KR
South Korea
Prior art keywords
cement
orthopedic
antibiotic
antibiotics
mixed
Prior art date
Application number
KR1019940000382A
Other languages
English (en)
Other versions
KR0139235B1 (ko
Inventor
조세현
Original Assignee
조세현
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 조세현 filed Critical 조세현
Priority to KR1019950000382A priority Critical patent/KR0139235B1/ko
Priority to GB9501063A priority patent/GB2285924B/en
Priority to FR9500762A priority patent/FR2715567B1/fr
Priority to JP7010879A priority patent/JP2579452B2/ja
Priority to AU11427/95A priority patent/AU685202B2/en
Priority to ES09500150A priority patent/ES2111450B1/es
Priority to US08/380,863 priority patent/US5641514A/en
Publication of KR950023418A publication Critical patent/KR950023418A/ko
Priority to HK98102919A priority patent/HK1003825A1/xx
Application granted granted Critical
Publication of KR0139235B1 publication Critical patent/KR0139235B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Farming Of Fish And Shellfish (AREA)

Abstract

본 발명은 정형외과용 세멘트비드 조성물 및 그의 제조방법에 관한 것으로, 만성골수염환자를 1차소파술을 시술한 후 생성되는 사공(死空, deadspace)에 채워넣는, 항생제와 세멘트를 혼합하여 제조한 정형외과용 세멘트비드이다.
만성골수염은 재발의 진도가 높고 각종 항생제에 내성이 강한 원인미생물이 많은 것이 특징인바, 원인미생물의 내성(저항성) 역시 완치를 위해서는 집중적인 관리가 요구된다.
따라서, 본 발명은 1차소파술후 생긴 사공(死空, deadspace)에 채워 넣어 직접적인 살균효과를 얻고자 고안된 것으로, 많은 미생물에 유효하고 열안정을 갖춘 이상적인 항생제들을 혼합하여 조성시킴으로서 재발의 위험성은 물론 전신적 부작용을 줄이고자 안출된 것으로, 항생제 혼합비율이 페니실린계 티카실린 5-10g, 세파로스포린계 세파졸린 5-10g, 아미노글리코사이드계 토브라마이신 5-10g 및 폴리펩타이드계 광범위 항생제 반코마이신 5g의 항생제를 혼합하여 파우더세멘트와 균질화시킨후, 이를 액체세멘트에 혼합한 다음, 경화되는 도중에 비드형태로 잘라서 실에 연결하여 사용하는 것이다.

Description

정형외과용 세멘트 비드조성물 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 정형외과용 세멘트 비드 조성물에 있어서, 항생제 혼합비용이 티카실린 5-10g, 세파졸린 5-10g, 토브라마이신 5-10g 및 반코마이신 5g으로 조성원 항생제 혼합분말 20-25cc와 파우다 세멘트 120cc의 비 및 액체 세멘트 20-30cc가 혼합된 정형외과용 세멘트비드 조성물.
  2. 정형외과용 항생제 혼합 세멘트비드를 제조함 있어서, 티카실린 5-l0g, 세파졸린 5-10g, 토브라마이신 5-10g 및 반코마이신 5g의 항생제를 무균하에서 혼합한후, 이 항생제분말 20-25cc에 파우다 세멘트(Polymehyl methacrylate) 120cc를 가하여 혼합, 군질화시킨후, 균질화된 분말을 액체 세멘트 20-30cc에 혼합하여, 굳어져가는 도중에 직경 약 5mm의 크기로 절단한 후 실에 꿰어 연결시킴을 특징으로 하는 정형외과용 세멘트비드의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950000382A 1994-01-29 1995-01-11 정형외과용 세멘트 비드조성물 및 그의 제조방법 KR0139235B1 (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1019950000382A KR0139235B1 (ko) 1994-01-29 1995-01-11 정형외과용 세멘트 비드조성물 및 그의 제조방법
GB9501063A GB2285924B (en) 1994-01-29 1995-01-18 Polymer beads containing antibiotics for use in orthopaedic surgery
FR9500762A FR2715567B1 (fr) 1994-01-29 1995-01-24 Composition de billes de ciment pour la chirurgie orthopedique et son procede de fabrication
JP7010879A JP2579452B2 (ja) 1994-01-29 1995-01-26 骨治療用セメントビーズ及びその製造方法
AU11427/95A AU685202B2 (en) 1994-01-29 1995-01-27 Bead composition for orthopaedic surgery and its manufacturing process
ES09500150A ES2111450B1 (es) 1994-01-29 1995-01-27 Composicion de perlas de cemento para la cirugia ortopedica y su procedimiento de fabricacion.
US08/380,863 US5641514A (en) 1994-01-29 1995-01-30 Cement bead composition for orthopaedic surgery and its manufacturing process
HK98102919A HK1003825A1 (en) 1994-01-29 1998-04-08 Polymer beads containing antibiotics for use in orthopaedic surgery

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19940001632 1994-01-29
KR94-1632 1994-01-29
KR1019950000382A KR0139235B1 (ko) 1994-01-29 1995-01-11 정형외과용 세멘트 비드조성물 및 그의 제조방법

Publications (2)

Publication Number Publication Date
KR950023418A true KR950023418A (ko) 1995-08-18
KR0139235B1 KR0139235B1 (ko) 1998-04-28

Family

ID=26630184

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950000382A KR0139235B1 (ko) 1994-01-29 1995-01-11 정형외과용 세멘트 비드조성물 및 그의 제조방법

Country Status (8)

Country Link
US (1) US5641514A (ko)
JP (1) JP2579452B2 (ko)
KR (1) KR0139235B1 (ko)
AU (1) AU685202B2 (ko)
ES (1) ES2111450B1 (ko)
FR (1) FR2715567B1 (ko)
GB (1) GB2285924B (ko)
HK (1) HK1003825A1 (ko)

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US20090202609A1 (en) * 2008-01-06 2009-08-13 Keough Steven J Medical device with coating composition
US8469961B2 (en) * 2008-03-05 2013-06-25 Neville Alleyne Methods and compositions for minimally invasive capsular augmentation of canine coxofemoral joints
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Also Published As

Publication number Publication date
HK1003825A1 (en) 1998-11-06
FR2715567B1 (fr) 1996-10-11
ES2111450B1 (es) 1999-07-01
GB9501063D0 (en) 1995-03-08
US5641514A (en) 1997-06-24
AU1142795A (en) 1995-08-10
JP2579452B2 (ja) 1997-02-05
KR0139235B1 (ko) 1998-04-28
GB2285924A (en) 1995-08-02
FR2715567A1 (fr) 1995-08-04
JPH07308374A (ja) 1995-11-28
AU685202B2 (en) 1998-01-15
GB2285924B (en) 1998-01-28
ES2111450A1 (es) 1998-03-01

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