KR950017877A - Cyclopropane Derivatives and Preparation Methods - Google Patents

Cyclopropane Derivatives and Preparation Methods Download PDF

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Publication number
KR950017877A
KR950017877A KR1019930028457A KR930028457A KR950017877A KR 950017877 A KR950017877 A KR 950017877A KR 1019930028457 A KR1019930028457 A KR 1019930028457A KR 930028457 A KR930028457 A KR 930028457A KR 950017877 A KR950017877 A KR 950017877A
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KR
South Korea
Prior art keywords
formula
cyclopropane
compound
poph
ewg
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Application number
KR1019930028457A
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Korean (ko)
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KR960008634B1 (en
Inventor
김윤철
Original Assignee
하기주
주식회사 코오롱
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Priority to KR93028457A priority Critical patent/KR960008634B1/en
Publication of KR950017877A publication Critical patent/KR950017877A/en
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Publication of KR960008634B1 publication Critical patent/KR960008634B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/184—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring to a carbon atom of a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/188—Unsaturated ethers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

본 발명은 아래 일반식(I)로 표시되는 새로운 시클로프로판 유도체 및 그의 제조방법에 관한 것으로, 다음 구조식 (II)의 불포화아세탈알리드와 구조식(III)의 활성화 올레핀과의 부가반응에 이은 고리화반응에 의해 THF, 에테르 등의 적당한 용매에서 -40 내지 20℃범위의 온도에서 제조될 수 있다.The present invention relates to a novel cyclopropane derivative represented by the following general formula (I) and a method for preparing the same, followed by addition reaction between unsaturated acetal ally of formula (II) and activated olefin of formula (III) The reaction can be prepared at a temperature in the range of -40 to 20 ° C. in a suitable solvent such as THF, ether or the like.

위 식에서, R은 수소원자 또는 탄소원자수 1-6의 유기잔기이고, EWG는 -PPh3, -POPh2, -S02Ph중에서 선택되는 기이다.In the above formula, R is a hydrogen atom or an organic residue having 1 to 6 carbon atoms, and EWG is a group selected from -PPh 3 , -POPh 2 , and -S0 2 Ph.

본 발명의 화합물은 시클로프로판 고리에 알콕시기, 비닐기, 친전자성 치환제가 도입된 활성화된 시클로프로판 화합물로서, 사코마이신 등의 향생제, 향종양재의 중간체 및 정밀화학 제품의 중간체로서 매우 유용한 화합물이다.The compound of the present invention is an activated cyclopropane compound in which an alkoxy group, a vinyl group, and an electrophilic substituent are introduced into the cyclopropane ring, which is very useful as an intermediate of fragrances such as sacommycin, an intermediate of perfumery, and a fine chemical to be.

Description

시클로프로판 유도체 및 그 제조방법Cyclopropane Derivatives and Preparation Methods

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

알콕시기, 비닐기, 친전자성 치환체를 가진 활성화된 시클로프로판 유도체.Activated cyclopropane derivatives having alkoxy groups, vinyl groups, electrophilic substituents. 식에서, R은 수소원자 또는 탄소원자수 1-6의 유기잔기이며, EWG는 -PPh3, -POPh2, -SO2Ph중에서 선택되는 기이다.In the formula, R is an organic residue having 1 to 6 hydrogen atoms or carbon atoms, and EWG is a group selected from -PPh 3 , -POPh 2 , and -SO 2 Ph. 아래 일반식(Ⅱ)의 화합물과 아래 일반식(Ⅲ)의 화합물을 반응시켜서 일반식(Ⅰ)의 시클로프로판 유도체를 제조하는 방법.A method for producing a cyclopropane derivative of formula (I) by reacting a compound of formula (II) below with a compound of formula (III) below. 식에서, R은 수소원자 또는 탄소원자수 1-6의 유기잔기이며, EWG는 -PPh3, -POPh2, -SO2Ph중에서 선택되는 기이다.In the formula, R is an organic residue having 1 to 6 hydrogen atoms or carbon atoms, and EWG is a group selected from -PPh 3 , -POPh 2 , and -SO 2 Ph. 제2항에 있어서, 용매로서 THF 또는 에테르를 사용하는 방법.The method of claim 2 wherein THF or ether is used as solvent. 제2항에 있어서, 반응온도가 -40 -25℃인 방법.The process of claim 2 wherein the reaction temperature is -40 -25 ° C. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR93028457A 1993-12-18 1993-12-18 Cyclo propane derivatives and its preparation KR960008634B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR93028457A KR960008634B1 (en) 1993-12-18 1993-12-18 Cyclo propane derivatives and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR93028457A KR960008634B1 (en) 1993-12-18 1993-12-18 Cyclo propane derivatives and its preparation

Publications (2)

Publication Number Publication Date
KR950017877A true KR950017877A (en) 1995-07-20
KR960008634B1 KR960008634B1 (en) 1996-06-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR93028457A KR960008634B1 (en) 1993-12-18 1993-12-18 Cyclo propane derivatives and its preparation

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Publication number Publication date
KR960008634B1 (en) 1996-06-28

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