KR870007884A - Production method of indole - Google Patents

Production method of indole Download PDF

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Publication number
KR870007884A
KR870007884A KR1019860001256A KR860001256A KR870007884A KR 870007884 A KR870007884 A KR 870007884A KR 1019860001256 A KR1019860001256 A KR 1019860001256A KR 860001256 A KR860001256 A KR 860001256A KR 870007884 A KR870007884 A KR 870007884A
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KR
South Korea
Prior art keywords
indole
group
compound
glyoxal
aniline
Prior art date
Application number
KR1019860001256A
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Korean (ko)
Other versions
KR900007418B1 (en
Inventor
박남규
최기석
김계현
Original Assignee
주식회사 코오롱
이상철
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 주식회사 코오롱, 이상철 filed Critical 주식회사 코오롱
Priority to KR1019860001256A priority Critical patent/KR900007418B1/en
Publication of KR870007884A publication Critical patent/KR870007884A/en
Application granted granted Critical
Publication of KR900007418B1 publication Critical patent/KR900007418B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)

Abstract

내용 없음No content

Description

인돌류의 제조방법Production method of indole

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

인돌 또는 그 핵치환 유도체를 제조하는데 있어서, 아닐린 또는 그 핵치환유도체인 다음 일반식(Ⅰ)에 글리옥살을 첨가시키되, 그 몰비가 0.5내지 20:1이 되도록 첨가시키고, 15。내지 150℃의 저온에서 합성 반응시켜서 다음 일반식(Ⅱ)의 화합물을 제조한 다음, 이 화합물을 촉매존재 또는 촉매없이 열분해시켜서 다음 일반식(Ⅲ)으로 표시되는 인돌류 화합물이 생성되어지도록 함을 특징으로 하는 인돌류의 제조방법.In preparing an indole or a nuclear substituted derivative thereof, glyoxal is added to the following general formula (I), which is an aniline or a nuclear substituted derivative thereof, so that the molar ratio is 0.5 to 20: 1, and 15 ° to 150 ° C. Synthesis reaction at low temperature to prepare the compound of formula (II), and then pyrolyze the compound without or without a catalyst to produce an indole compound represented by the following formula (III) Method of preparation (단, X는 탄소원자수가 1내지 4의 알킬기, 니트로기, 히드록시기 또는 할로겐기이며, n은 0내지 4의 정수이고, n2일 경우에는 적어도 2개 이상의 관능기를 포함할 수 있음.(Wherein X is an alkyl group having 1 to 4 carbon atoms, a nitro group, a hydroxy group or a halogen group, n is an integer of 0 to 4, n is 2 may include at least two functional groups. 제1항에 있어서, 아닐린 또는 그 핵유도체는 글리옥살과 각각 분리되어 열분해반응관에 투입되어지도록 하는 것을 특징으로 하는 방법.The method of claim 1, wherein the aniline or its nuclear derivative is separated from glyoxal and introduced into a pyrolysis tube. 제1항에 있어서, 촉매는 주기율표의 Ⅱa족에 해당하는 금속염을 사용하여서 되어지는 방법_The process of claim 1 wherein the catalyst is made using a metal salt of Group IIa of the Periodic Table. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860001256A 1986-02-22 1986-02-22 Process for preparing indoles KR900007418B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019860001256A KR900007418B1 (en) 1986-02-22 1986-02-22 Process for preparing indoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019860001256A KR900007418B1 (en) 1986-02-22 1986-02-22 Process for preparing indoles

Publications (2)

Publication Number Publication Date
KR870007884A true KR870007884A (en) 1987-09-22
KR900007418B1 KR900007418B1 (en) 1990-10-08

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ID=19248569

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860001256A KR900007418B1 (en) 1986-02-22 1986-02-22 Process for preparing indoles

Country Status (1)

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KR (1) KR900007418B1 (en)

Also Published As

Publication number Publication date
KR900007418B1 (en) 1990-10-08

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