KR900016182A - Preparation of 4,8-inter-m-phenylene PGI₂ derivative - Google Patents

Preparation of 4,8-inter-m-phenylene PGI₂ derivative Download PDF

Info

Publication number
KR900016182A
KR900016182A KR1019890004904A KR890004904A KR900016182A KR 900016182 A KR900016182 A KR 900016182A KR 1019890004904 A KR1019890004904 A KR 1019890004904A KR 890004904 A KR890004904 A KR 890004904A KR 900016182 A KR900016182 A KR 900016182A
Authority
KR
South Korea
Prior art keywords
group
carbon atoms
inter
preparation
derivative
Prior art date
Application number
KR1019890004904A
Other languages
Korean (ko)
Other versions
KR970001487B1 (en
Inventor
기요다카 오오노
히로시 나가세
유다까 호소노
Original Assignee
마에다 카쓰노스케
도오레 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 마에다 카쓰노스케, 도오레 가부시기가이샤 filed Critical 마에다 카쓰노스케
Priority to KR1019890004904A priority Critical patent/KR970001487B1/en
Publication of KR900016182A publication Critical patent/KR900016182A/en
Application granted granted Critical
Publication of KR970001487B1 publication Critical patent/KR970001487B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.No content.

Description

4, 8-인터-m-페닐렌 PGI2유도체의 제조법Preparation of 4,8-inter-m-phenylene PGI2 derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

일반식 (I)Formula (I) (식중, R1은 수소 또는 탄소수 1 내지 2의 직쇄알킬기를 표시하고, R2는 탄소수 2 내지 10의 아실기, 탄소수 7 내지 18의 아로일기, 탄소수 3 내지 18의 알킬 시릴기, 또는 탄소수 7 내지 18의 아릴시릴기를 표시하고, R3는 수소, 메틸기 또는 에틸기를 표시하고, R4는 탄소수 1 내지 5의 직쇄의 알킬기를 표시하고, A는,(Wherein R 1 represents hydrogen or a straight chain alkyl group having 1 to 2 carbon atoms, R 2 represents an acyl group having 2 to 10 carbon atoms, an aroyl group having 7 to 18 carbon atoms, an alkyl silyl group having 3 to 18 carbon atoms, or 7 carbon atoms) To an arylsilyl group of 18 to 18, R 3 represents hydrogen, a methyl group or an ethyl group, R 4 represents a linear alkyl group having 1 to 5 carbon atoms, and A is 1) -CH2-CH2-CH2- 2) CH2-CH2- 또는 3) -O-CH2-를 표시한다)로 표시되는 화합물의 15위의 수산기를 광연 시약을 사용하여 반전하고, 용매를 더하여 분해 또는 가수분해 하는 것을 특징으로 하는 일반식(II) 1) -CH 2 -CH 2 -CH 2 - 2) CH 2 -CH 2 - or 3) -O-CH 2 - by using Mitsunobu reagent of the hydroxy group of the compound represented by the above 15 displays) and reverse Formula (II), wherein the solvent is added to decompose or hydrolyze. (식중 R1, R3, R4및 A는 전기한 정의과 같음)로 표시되는 4, 8-인터-m-페닐렌 PGI2의 유도체의 제조법.A method for producing a derivative of 4,8-inter-m-phenylene PGI 2 , wherein R 1 , R 3 , R 4 and A are as defined above. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890004904A 1989-04-13 1989-04-13 4,8-inter-m-phenylene pgi2 derivatives KR970001487B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019890004904A KR970001487B1 (en) 1989-04-13 1989-04-13 4,8-inter-m-phenylene pgi2 derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019890004904A KR970001487B1 (en) 1989-04-13 1989-04-13 4,8-inter-m-phenylene pgi2 derivatives

Publications (2)

Publication Number Publication Date
KR900016182A true KR900016182A (en) 1990-11-12
KR970001487B1 KR970001487B1 (en) 1997-02-06

Family

ID=19285328

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890004904A KR970001487B1 (en) 1989-04-13 1989-04-13 4,8-inter-m-phenylene pgi2 derivatives

Country Status (1)

Country Link
KR (1) KR970001487B1 (en)

Also Published As

Publication number Publication date
KR970001487B1 (en) 1997-02-06

Similar Documents

Publication Publication Date Title
KR860001104A (en) Method for producing tetrahydrophthalimide
KR870006039A (en) Novel thiazole compound, preparation method thereof and pharmaceutical composition containing the compound
KR900016190A (en) 2-phenylpyridine
KR860700250A (en) New amidine compounds
KR900016182A (en) Preparation of 4,8-inter-m-phenylene PGI₂ derivative
KR830006302A (en) Method for preparing novel pyrimidine derivatives
KR900000378A (en) Tyrosine derivatives and preparation method thereof
KR830001900A (en) Phenylmorphane and its intermediates and preparation methods
KR830007693A (en) Improved method for preparing 7-amino cefem compound
KR930700412A (en) Method for preparing α-amino-β, δ-diol derivatives
KR920002497A (en) Sterol compound
KR870007907A (en) Preparation of diene derivative
KR910016673A (en) Method for preparing hydroxyphenyl propionate
KR900016184A (en) 1,3-dioxane derivative
KR860008184A (en) Preparation of Dioxolobenzoisoxazole Derivatives
KR910004644A (en) Process for the preparation of 2-deoxy-2,2-difluoroxylose analogs and intermediates thereof
KR870011124A (en) Method for preparing furan derivative
KR920009792A (en) Method for preparing 3-amino-4-methylenepyrrolidine derivative
KR840004105A (en) Process for preparing N, N-substituted azole carboxamide derivatives
KR930012664A (en) p-methoxybenzyl 2S-lactate and preparation method thereof
KR910007914A (en) Novel Method for Preparing Benzimidazole Derivatives
KR920012064A (en) Method for preparing lactone derivative
KR910011825A (en) Novel salicylic acid maltol ester derivative and preparation method thereof
KR850004471A (en) Process for preparing organic compound
KR860008195A (en) Process for preparing a novel phosphine compound

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20110126

Year of fee payment: 15

EXPY Expiration of term