KR910007914A - Novel Method for Preparing Benzimidazole Derivatives - Google Patents

Novel Method for Preparing Benzimidazole Derivatives Download PDF

Info

Publication number
KR910007914A
KR910007914A KR1019890015157A KR890015157A KR910007914A KR 910007914 A KR910007914 A KR 910007914A KR 1019890015157 A KR1019890015157 A KR 1019890015157A KR 890015157 A KR890015157 A KR 890015157A KR 910007914 A KR910007914 A KR 910007914A
Authority
KR
South Korea
Prior art keywords
compound
formula
following structural
structural formula
iii
Prior art date
Application number
KR1019890015157A
Other languages
Korean (ko)
Other versions
KR910009956B1 (en
Inventor
문순구
이관순
문영호
서강원
Original Assignee
임성기
한미약품공업 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 임성기, 한미약품공업 주식회사 filed Critical 임성기
Priority to KR1019890015157A priority Critical patent/KR910009956B1/en
Publication of KR910007914A publication Critical patent/KR910007914A/en
Application granted granted Critical
Publication of KR910009956B1 publication Critical patent/KR910009956B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음.No content.

Description

벤즈이미다졸 유도체의 신규한 제조방법Novel Method for Preparing Benzimidazole Derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (3)

벤즈이미다졸 유도체를 제조함에 있어서, 다음구조식(Ⅱ)의 알코올을 염기존재하에 다음구조식(Ⅲ)의 화합물과 반응시켜 다음구조식(Ⅳ)의 포스페이트에스테르 화합물을 얻고, 여기에다 다음 구조식(B)의 화합물을 반응시켜서 다음구조식(Ⅰ′) 화합물을 얻고 나서, 이 화합물을 산화시켜 다음구조식(Ⅰ)의 화합물을 제조하는 것을 특징으로 하는 벤즈이미다졸 유도체의 신규한 제조방법.In preparing the benzimidazole derivative, an alcohol of the following structural formula (II) is reacted with a compound of the following structural formula (III) in the presence of a base to obtain a phosphate ester compound of the following structural formula (IV), and a compound of the following structural formula (B) A reaction method for producing a benzimidazole derivative, characterized in that the compound of formula (I ') is obtained by oxidizing to form a compound of formula (I). 상기 식들중, Y는 산소 또는 황원자를 나타내고, R은 C1~4의 저급알킬 또는 치환되어 있어도 좋은 페닐기를 나타낸다.In the formulas, Y represents oxygen or a sulfur atom, and R represents C 1-4 lower alkyl or a phenyl group which may be substituted. 제1항에 있어서, 상기 구조식(Ⅲ)의 화합물로서는 디에틸클로로포스페이트, 디페닐클로로포스페이트, 디에틸클로로치오포스페이트 또는 디페니클로로치오포스페이트를 사용하여서 됨을 특징으로 하는 벤즈이미다졸 유도체의 제조방법.The method for producing benzimidazole derivatives according to claim 1, wherein diethylchlorophosphate, diphenylchlorophosphate, diethylchlorothiophosphate, or diphenylchlorothiophosphate is used as the compound of the formula (III). 제1항에 있어서, 상기 구조식(Ⅳ)의 화합물 제조시 사용되는 염기로서는 상기 구조식(Ⅲ)과 (Ⅳ)에서의 Y가 황원자인 경우에는 NaH를 사용하고, Y가 산소원자인 경우에는 트리에틸아민을 사용하여서 됨을 특징으로 하는 벤즈이미다졸 유도체의 제조방법.The base used in the preparation of the compound of the formula (IV) is NaH when Y in the formulas (III) and (IV) is a sulfur atom, and triethyl when Y is an oxygen atom. A method for producing a benzimidazole derivative, characterized by using an amine. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890015157A 1989-10-21 1989-10-21 Process for preparation of benzimidazol derivatives KR910009956B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019890015157A KR910009956B1 (en) 1989-10-21 1989-10-21 Process for preparation of benzimidazol derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019890015157A KR910009956B1 (en) 1989-10-21 1989-10-21 Process for preparation of benzimidazol derivatives

Publications (2)

Publication Number Publication Date
KR910007914A true KR910007914A (en) 1991-05-30
KR910009956B1 KR910009956B1 (en) 1991-12-07

Family

ID=19290893

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890015157A KR910009956B1 (en) 1989-10-21 1989-10-21 Process for preparation of benzimidazol derivatives

Country Status (1)

Country Link
KR (1) KR910009956B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100821165B1 (en) * 2006-03-10 2008-04-14 동우신테크 주식회사 Process for preparing lercanidipine hydrochloride

Also Published As

Publication number Publication date
KR910009956B1 (en) 1991-12-07

Similar Documents

Publication Publication Date Title
KR860001793A (en) Method for preparing benzimidazole derivatives
KR830007686A (en) Method for preparing cephalosporin derivative
KR860000243A (en) Method for preparing amine derivative
KR840003260A (en) Preparation of [(3-amino-3-carboxy) -propyl-1] phosphinic acid derivative
KR850004754A (en) Method for producing 3-indole carboxamide compounds
KR830005090A (en) 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaene acid
KR830010039A (en) Method for preparing phenyl fatty carboxylic acid derivative
KR880701233A (en) New biphenyl derivatives and methods for their preparation and uses
KR830004320A (en) Method for preparing quinazoline derivatives
KR910007914A (en) Novel Method for Preparing Benzimidazole Derivatives
KR840002821A (en) Method for preparing N- (2,3-epoxypropylene) -N-aralkylsulfonamide derivative
KR830005122A (en) Method for producing 1-aryloxy-3-alkylamino-2-propanols
KR880000377A (en) Preparation method of trans hexahydro terephthalic acid ester derivative
KR860004030A (en) Method for preparing bromodichloro imidazole insecticide
KR850003407A (en) Process for preparing organophosphate ester derivative
KR850005411A (en) Method for preparing α-methyl- (6-phenoxy) -2-picolinyl cyclopropane carboxylate
KR880001635A (en) 5-Fluorouracil derivatives, preparation method and use thereof
KR870003114A (en) Tetrahydroisoquinoline derivatives
KR850001742A (en) Process for preparing cumalic acid ester
KR850007247A (en) Method for preparing biphenylylsulfonyl urea
KR830002746A (en) Preparation method and herbicidal composition of tetrahydrophthalamide derivative
KR840002842A (en) Method for preparing 2-phenylimidazo [2,1-b] benzothiazole compound
KR840004105A (en) Process for preparing N, N-substituted azole carboxamide derivatives
KR840002848A (en) Method for preparing organophosphate
KR900006295A (en) Halogeno-4-methylpyrazoles and preparation method thereof

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
O035 Opposition [patent]: request for opposition

Free format text: OPPOSITION NUMBER: 001992001364; OPPOSITION DATE: 19920207