KR950016718A - Ibuprofen-containing solid composition - Google Patents

Ibuprofen-containing solid composition Download PDF

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Publication number
KR950016718A
KR950016718A KR1019940034202A KR19940034202A KR950016718A KR 950016718 A KR950016718 A KR 950016718A KR 1019940034202 A KR1019940034202 A KR 1019940034202A KR 19940034202 A KR19940034202 A KR 19940034202A KR 950016718 A KR950016718 A KR 950016718A
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KR
South Korea
Prior art keywords
ibuprofen
solid composition
coated
containing solid
saccharide
Prior art date
Application number
KR1019940034202A
Other languages
Korean (ko)
Other versions
KR100253525B1 (en
Inventor
히데요시 칸베
요우이치 나카지마
아키라 이와사
Original Assignee
원본미기재
에스에스 세이야큐 가부시키가이샤
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Application filed by 원본미기재, 에스에스 세이야큐 가부시키가이샤 filed Critical 원본미기재
Publication of KR950016718A publication Critical patent/KR950016718A/en
Application granted granted Critical
Publication of KR100253525B1 publication Critical patent/KR100253525B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 이부프로펜 함유 코어, 상기 이부프로펜 함유 코어의 표면에 수불용성 고분자 화합물로 피복하고, 이 수불용성 고분자 화합물의 피복표면에 피복된 당알코올 또는 사카라이드로 구성된 피복된 이부프로펜 함유 고형 조성물을 개시한다. 본 발명의 조성물은 이부프로펜 함유 고형제제에서 이부프로펜의 자극적 쓴맛이 마스킹된다. 또한, 이러한 고형제제는 이부프로펜의 자극적인 쓴맛과 승화를 억제하고 지속적인 마스킹 효과를 나타내며, 입자가 흡습, 고화 또는 변색되지 않은 우수한 경시 안정성을 나타낸다.The present invention discloses a coated ibuprofen-containing solid composition composed of a sugar alcohol or saccharide coated on a surface of the ibuprofen-containing core and the surface of the ibuprofen-containing core with a water-insoluble high molecular compound. The composition of the present invention masks the irritating bitter taste of ibuprofen in ibuprofen containing solid preparations. In addition, these solid preparations suppress the irritating bitter taste and sublimation of ibuprofen and have a continuous masking effect, and exhibit excellent stability over time, with no particles being hygroscopic, solidified or discolored.

Description

이부프로펜 함유 고형 조성물Ibuprofen-containing solid composition

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

이부프로펜 함유 입자, 수불용성 고분자 화합물 및 당알코올 또는 사카라이드로 구성되며, 상기 이부프로펜 함유 입자의 표면에 수불용성 고분자 화합물로 피복하고, 이 피복표면에 당알코올 또는 사카라이드로 피복된 이부프로펜 함유 고형 조성물.An ibuprofen-containing solid composition comprising ibuprofen-containing particles, a water-insoluble high molecular compound and a sugar alcohol or a saccharide, coated with a water-insoluble high molecular compound on the surface of the ibuprofen-containing particle, and coated with a sugar alcohol or a saccharide on the coating surface. 제1항에 있어서, 입자에 피복되는 수불용성 고분자 화합물의 양이 이부프로펜 함유 입자에 대해 2∼10중량%인 이부프로펜 함유 고형 조성물.The ibuprofen-containing solid composition according to claim 1, wherein the amount of the water-insoluble high molecular compound coated on the particles is 2 to 10% by weight based on the ibuprofen-containing particles. 제1항에 있어서, 피복되는 당알코올 또는 사카라이드의 양이 이부프로펜함유 입자에 대해 2∼20중량%인 이부프로펜 함유 고형 조성물.The ibuprofen-containing solid composition according to claim 1, wherein the amount of sugar alcohol or saccharide to be coated is 2 to 20% by weight based on the ibuprofen-containing particles. 제1항에 있어서, 미세 과립제, 과립제, 캅셀제 또는 정제인 이부프로펜 함유 고형 조성물The ibuprofen-containing solid composition according to claim 1, which is a fine granule, granule, capsule or tablet. 이부프로펜 함유 입자를 수불용성 고분자 화합물로 피복하고, 이 수불용성 고분자 화합물로 피복 표면에 당알코올 또는 사카라이드로 피복함을 특징으로 하는 이부프로펜 함유 고형 조성물의 제조방법.A method for producing a ibuprofen-containing solid composition, wherein the ibuprofen-containing particles are coated with a water-insoluble high molecular compound, and the coating surface is coated with a sugar alcohol or a saccharide. 제1항에서 정의된 이부프로펜 함유 고형 조성물과, 아스코르브산, 말레인산 클로로페닐아민 및 염산 메틸에페돌린으로 구성된 군에서 선택된 약물을 함유하는 고형 조성물로 이루어진 의약 조성물.A pharmaceutical composition comprising a ibuprofen-containing solid composition as defined in claim 1 and a solid composition containing a drug selected from the group consisting of ascorbic acid, maleic acid chlorophenylamine, and methylephedolin hydrochloride. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019940034202A 1993-12-17 1994-12-14 Ibuprofen-containing solid composition KR100253525B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP318530/1993 1993-12-17
JP5318530A JP2841267B2 (en) 1993-12-17 1993-12-17 Ibuprofen-containing granules

Publications (2)

Publication Number Publication Date
KR950016718A true KR950016718A (en) 1995-07-20
KR100253525B1 KR100253525B1 (en) 2000-05-01

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ID=18100149

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Application Number Title Priority Date Filing Date
KR1019940034202A KR100253525B1 (en) 1993-12-17 1994-12-14 Ibuprofen-containing solid composition

Country Status (4)

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JP (1) JP2841267B2 (en)
KR (1) KR100253525B1 (en)
CN (1) CN1090477C (en)
TW (1) TW276994B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1047407A4 (en) * 1997-12-19 2007-05-02 Smithkline Beecham Corp Process for manufacturing bite-dispersion tablets
JP2005035995A (en) * 2003-07-01 2005-02-10 Sankyo Co Ltd Ibuprofen-containing oral composition
JP4913359B2 (en) * 2004-05-07 2012-04-11 第一三共ヘルスケア株式会社 Ibuprofen-containing pharmaceutical composition
JP2012046540A (en) * 2004-05-07 2012-03-08 Daiichi Sankyo Healthcare Co Ltd Ibuprofen-containing pharmaceutical composition
JP4832045B2 (en) * 2005-09-28 2011-12-07 ロート製薬株式会社 Pharmaceutical composition containing mequitazine, ibuprofen and tranexamic acid
JP5465824B2 (en) * 2006-03-24 2014-04-09 第一三共ヘルスケア株式会社 Pharmaceutical preparation and method for producing the same
JP5527921B2 (en) * 2006-12-22 2014-06-25 エスエス製薬株式会社 Oral solid composition concealing bitterness
SG10201407947WA (en) * 2009-11-30 2015-01-29 Aptalis Pharmatech Inc Compressible-coated pharmaceutical compositions and tablets and methods of manufacture
WO2013183062A2 (en) * 2012-06-05 2013-12-12 Rubicon Research Private Limited Palatable formulations of ibuprofen
TR201902206T4 (en) * 2013-06-17 2019-03-21 Nippon Soda Co Coating agent containing hydroxyalkyl cellulose.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0297866A3 (en) * 1987-07-01 1989-12-13 The Boots Company PLC Therapeutic agents

Also Published As

Publication number Publication date
JP2841267B2 (en) 1998-12-24
JPH07173057A (en) 1995-07-11
CN1090477C (en) 2002-09-11
CN1109745A (en) 1995-10-11
TW276994B (en) 1996-06-01
KR100253525B1 (en) 2000-05-01

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