KR950011615A - 신규 아실-코에이 : 콜레스테롤 아실전이효소(acat) 활성 저해물질 및 이의 제조방법 - Google Patents

신규 아실-코에이 : 콜레스테롤 아실전이효소(acat) 활성 저해물질 및 이의 제조방법 Download PDF

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KR950011615A
KR950011615A KR1019940019984A KR19940019984A KR950011615A KR 950011615 A KR950011615 A KR 950011615A KR 1019940019984 A KR1019940019984 A KR 1019940019984A KR 19940019984 A KR19940019984 A KR 19940019984A KR 950011615 A KR950011615 A KR 950011615A
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geri
coa
acat
cholesterol acyltransferase
activity inhibitor
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KR1019940019984A
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KR0125129B1 (ko
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복성해
정태숙
김성욱
권병목
김영국
손광희
이항우
권용국
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김은영
한국과학기술연구원
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid

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Abstract

본 발명은 토양으로부터 분리된 곰팡이 아스퍼질러스 푸미가투스(Aspergillus fumigatus) FM-F-37로부터 분리된, 아실-CoA : 콜레스테롤 아실전이효소의 저해제인 하기 구조식(I)의 GERI-BP001, 그의 유도체 및 그의 제조방법에 관한 것이다.

Description

신규 아실-코에이 : 콜레스테롤 아실전이효소(ACAT) 활성 저해물질 및 이의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 자외선-가시광선 분광기에 의한GERI-BP0001의 흡광도 분석 스펙트럼을 나타내는 도면이고,
제 2 도는 비율기록 적외선 분광기에 의한 GERI-BP001의 흡광도 분석 스펙트럼을 나타내는 도면이고,
제 3 도는 비율기록 적외선 분광기에 의한 GERI-BP001-C의 흡광도 분석 스펙트럼을 나타내는 도면이고,
제 4 도는 VG70-VSEQ 질량분석기에 의한 GERI-BP001의 HREI-MS 분자량 분석 스펙트럼을 나타내는 도면이고,
제 5 도는 VG70-VSEQ 질량분석기에 의한 GERI-BP001-A의 EI-MS 분자량 분석 스펙트럼을 나타내는 도면이고,
제 6 도는 VG70-VSEQ 질량분석기에 의한 GERI-BP001-B의 EI-MS 분자량 분석 스펙트럼을 나타내는 도면이고,
제 7 도는 브룩커(Bruker) AM-300에 의한 GERI-BP001의 300MHz에서의1H-NMR 분석 스펙트럼을 나타내는 도면이고,

Claims (6)

  1. 하기 구조식(I)의 신규 화합물 GERI-BP001 및 그의 유도체 :
  2. 제 1항에 있어서, 각각 하기 구조식(I-1), (I-2) 및 (I-3)을 갖는 유도체 GERI-BP001-A, GERI-BP001-B 및 GERI-BP001-C로 이루어진 그룹으로부터 선택된 유도체 :
  3. GERI-BP001 생산균주인 아스퍼질러스 푸미가투스(Aspergillus fumigatus) FM-F-37 균주(KCTC 0087BP).
  4. 아스퍼질러스 푸미가투스(Aspergillus fumigatus) FM-F-37 균주(KCTC 0087BP)를 배양함을 포함하는, GERI-BP001, GERI-BP001-A 또는 GERI-BP001-B의 제조방법
  5. GERI - BP001 화합물로 부터 핵진화성 치환반응에 의해 호학적으로 합성함을 포함하는 GERI - BP001-C의 제조방법.
  6. 활성물질로서 GERI -BP001, GERI -BP001-A GERI -BP001-B 또는 GERI -BP001-C 를 포함하는, 아실- CoA : 콜레스테롤 아실전이 효소(ACAT) 활성 저해제로 사용하기 위한 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940019984A 1993-10-08 1994-08-13 신규 아실-코에이 : 콜레스테롤 아실전이효소(acat) 활성 저해물질 및 이의 제조 방법 KR0125129B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019940019984A KR0125129B1 (ko) 1993-10-08 1994-08-13 신규 아실-코에이 : 콜레스테롤 아실전이효소(acat) 활성 저해물질 및 이의 제조 방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR93-20886 1993-10-08
KR930020886 1993-10-08
KR1019940019984A KR0125129B1 (ko) 1993-10-08 1994-08-13 신규 아실-코에이 : 콜레스테롤 아실전이효소(acat) 활성 저해물질 및 이의 제조 방법

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KR950011615A true KR950011615A (ko) 1995-05-15
KR0125129B1 KR0125129B1 (ko) 1997-11-28

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Country Link
US (1) US5597835A (ko)
KR (1) KR0125129B1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980081832A (ko) * 1997-04-30 1998-11-25

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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ES2439229T3 (es) 2004-10-06 2014-01-22 The Brigham And Women's Hospital, Inc. Relevancia de niveles logrados de marcadores de inflamación sistémica tras el tratamiento
US8557550B2 (en) 2008-07-24 2013-10-15 Meija Seika Pharma Co., Ltd. Pyripyropene a biosynthetic gene
AU2011210967B2 (en) 2010-01-26 2016-06-23 Mitsui Chemicals Crop & Life Solutions, Inc. Method for manufacturing a pyripyropene
CA2787829A1 (en) 2010-01-26 2011-08-04 Meiji Seika Pharma Co., Ltd. Method for producing pyripyropene derivatives by the enzymatic method
EP2578084A4 (en) * 2010-05-24 2014-04-23 Meiji Seika Pharma Co Ltd MEANS OF COMBATING HARMFUL ORGANISMS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980081832A (ko) * 1997-04-30 1998-11-25

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