KR950011417A - N-substituted benzamidazole derivatives having amide groups - Google Patents

N-substituted benzamidazole derivatives having amide groups Download PDF

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Publication number
KR950011417A
KR950011417A KR1019930020833A KR930020833A KR950011417A KR 950011417 A KR950011417 A KR 950011417A KR 1019930020833 A KR1019930020833 A KR 1019930020833A KR 930020833 A KR930020833 A KR 930020833A KR 950011417 A KR950011417 A KR 950011417A
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South Korea
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formula
substituted
reaction
condensation reaction
carboxyalkyl
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KR1019930020833A
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Korean (ko)
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KR970001477B1 (en
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박영준
서귀현
윤희선
장만식
전재광
최완수
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김종인
영진약품공업 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 다음구조식(Ⅰ)로 표시되는 신규한 벤즈이미다졸 유도체와 그의 약제학적으로 허용가능한 염에 관한 것이다.The present invention relates to novel benzimidazole derivatives represented by the following structural formula (I) and pharmaceutically acceptable salts thereof.

상기식에서 Ar은 치환되거나 치환되지 않은 방향족 고리를 의미하며 n은 0 또는 1이다. R1은 치환반응이나, 축합반응으로 도입가능한 치환체로서 탄소수 1-6개의 저급 알킬, 시클로알킬, 히드록시알킬, 알콕시알킬, 아실기, 알콕시카보닐, 카르복시알킬등이다. R2은 수소를 포함하여 일반적인 치환체, 알콕시, 할로겐 등을 포함한다.In the formula, Ar means a substituted or unsubstituted aromatic ring and n is 0 or 1. R 1 is a lower alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, acyl group, alkoxycarbonyl, carboxyalkyl or the like as a substituent which can be introduced by a substitution reaction or a condensation reaction. R 2 includes hydrogen, common substituents, alkoxy, halogen and the like.

Description

아미드기를 가지는 N-치환된 벤즈아미다졸 유도체N-substituted benzamidazole derivatives having amide groups

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

다음구조식(Ⅰ)로 표시되는 신규한 벤즈이미다졸 유도체와 그의 약제학적으로 허용가능한 염에 관한 것이다.A novel benzimidazole derivative represented by the following formula (I) and a pharmaceutically acceptable salt thereof. 상기식에서 Ar은 치환되거나 치환되지 않은 방향족 고리를 의미하며 n은 0 또는 1이다. R1은 치환반응이나, 축합반응으로 도입가능한 치환체로서 탄소수 1-6개의 저급 알킬, 시클로알킬, 히드록시알킬, 알콕시알킬, 아실기, 알콕시카보닐, 카르복시알킬등이다. R2은 수소를 포함하여 일반적인 치환체, 알콕시, 할로겐 등을 포함한다.In the formula, Ar means a substituted or unsubstituted aromatic ring and n is 0 or 1. R 1 is a lower alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, acyl group, alkoxycarbonyl, carboxyalkyl or the like as a substituent which can be introduced by a substitution reaction or a condensation reaction. R 2 includes hydrogen, common substituents, alkoxy, halogen and the like. 다음구조식(Ⅱ),(Ⅲ),(Ⅳ)를 중간체로하여 산화반응이나, 치환 또는 축합반응을(Ⅰ)을 제조하는 방법Method of preparing (I) for oxidation reaction or substitution or condensation reaction using the following structural formulas (II), (III) and (IV) as intermediates 상기식에서 Ar,R1,R2는 앞에서 정의한바와 같다.In the above formula, Ar, R 1 , R 2 are as defined above. 다음구조식(Ⅰ)로 표시되는 벤즈이미다졸 유도체와 유효성분으로하는 항궤양성 약제Anti-ulcer agent as benzimidazole derivative represented by the following structural formula (I) and an active ingredient 상기식에서 Ar은 치환되거나 치환되지 않은 방향족 고리를 의미하며 n은 0 또는 1이다. R1은 치환반응이나, 축합반응으로 도입가능한 치환체로서 탄소수 1-6개의 저급 알킬, 시클로알킬, 히드록시알킬, 알콕시알킬, 아실기, 알콕시카보닐, 카르복시알킬등이다. R2은 수소를 포함하여 일반적인 치환체, 알콕시, 할로겐 등을 포함한다.In the formula, Ar means a substituted or unsubstituted aromatic ring and n is 0 or 1. R 1 is a lower alkyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, acyl group, alkoxycarbonyl, carboxyalkyl or the like as a substituent which can be introduced by a substitution reaction or a condensation reaction. R 2 includes hydrogen, common substituents, alkoxy, halogen and the like. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930020833A 1993-10-08 1993-10-08 N-substituted benzimidazole derivatives with amide groups KR970001477B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019930020833A KR970001477B1 (en) 1993-10-08 1993-10-08 N-substituted benzimidazole derivatives with amide groups

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019930020833A KR970001477B1 (en) 1993-10-08 1993-10-08 N-substituted benzimidazole derivatives with amide groups

Publications (2)

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KR950011417A true KR950011417A (en) 1995-05-15
KR970001477B1 KR970001477B1 (en) 1997-02-06

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