KR950008487A - New Benzimidazole Derivatives Having Amide Groups - Google Patents

New Benzimidazole Derivatives Having Amide Groups Download PDF

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Publication number
KR950008487A
KR950008487A KR1019930018059A KR930018059A KR950008487A KR 950008487 A KR950008487 A KR 950008487A KR 1019930018059 A KR1019930018059 A KR 1019930018059A KR 930018059 A KR930018059 A KR 930018059A KR 950008487 A KR950008487 A KR 950008487A
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South Korea
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group
carbon atoms
alkyl
hydrogen atom
substituted
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KR1019930018059A
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Korean (ko)
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KR970001476B1 (en
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윤희선
장만식
전재광
최완수
박영준
서귀현
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김종인
영진약품공업 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Abstract

본 발명은 다음 구조식(I)로 표시되는 신규한 벤즈이미다졸 유도체와 그의 제조방법에 관한 것이다.The present invention relates to a novel benzimidazole derivative represented by the following structural formula (I) and a preparation method thereof.

상기식에서 R1, R2, R3, R4, R5는 각각 서로 같거나 다른 것으로서 수소원자, 할로겐원자, 탄소수 1~6개의 저급 알킬, 시클로알킬, 또는 탄소수 1-6개의 저급 알콕시기, 치환되거나 치환되지 않은 페녹시기, 또는 치환되거나 치환되지 않은 아미노기들이다. R6, R7은 수소원자가 바람직하나, 메칠기를 포함한 탄소수 1~4개의 저급 알킬기로 포함할수 있다. R8은 수소, 메칠기를 포함하여 알킬, 할로겐,알콕시등이다. n은 0 또는 1이다.Wherein R 1 , R 2 , R 3 , R 4 , R 5 are the same as or different from each other, and each hydrogen atom, halogen atom, lower alkyl having 1 to 6 carbon atoms, cycloalkyl, lower alkoxy group having 1 to 6 carbon atoms, Substituted or unsubstituted phenoxy group, or substituted or unsubstituted amino groups. R 6 and R 7 preferably have a hydrogen atom, but may include a lower alkyl group having 1 to 4 carbon atoms including a methyl group. R 8 includes hydrogen, alkyl, alkyl, halogen, alkoxy and the like. n is 0 or 1;

Description

아미드기를 가지는 신규한 벤즈이미다졸 유도체New Benzimidazole Derivatives Having Amide Groups

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

다음 구조식(I)로 표시되는 신규한 벤즈이미다졸 유도체가 그의 약제학적으로 허용 가능한염.A novel benzimidazole derivative represented by the following structural formula (I) is a pharmaceutically acceptable salt thereof. 상기식에서 R1, R2, R3, R4, R5는 각각 서로 같거나 다른 것으로서 수소원자, 할로겐원자, 탄소수 1~6개의 저급 알킬, 시클로알킬, 또는 탄소수 1-6개의 저급 알콕시기, 치환되거나 치환되지 않은 페녹시기, 또는 치환되거나 치환되지 않은 아미노기들이다. R6, R7은 수소원자가 바람직하나, 메칠기를 포함한 탄소수 1~4개의 저급 알킬기로 포함할수 있다. R8은 수소, 메칠기를 포함하여 알킬, 할로겐,알콕시등이다. n은 0 또는 1이다.Wherein R 1 , R 2 , R 3 , R 4 , R 5 are the same as or different from each other, and each hydrogen atom, halogen atom, lower alkyl having 1 to 6 carbon atoms, cycloalkyl, lower alkoxy group having 1 to 6 carbon atoms, Substituted or unsubstituted phenoxy group, or substituted or unsubstituted amino groups. R 6 and R 7 preferably have a hydrogen atom, but may include a lower alkyl group having 1 to 4 carbon atoms including a methyl group. R 8 includes hydrogen, alkyl, alkyl, halogen, alkoxy and the like. n is 0 or 1; 다음 구조식(II)의 α-할로아미드, 다음 구조식(IV)2-메캅토벤즈이미다졸을 반응시켜 I (n=1)을 형성하고 이어서 산화하여 I (n=0)을 제조하는 방법.A method of preparing I (n = 0) by reacting α-haloamide of the following formula (II) with the following formula (IV) 2-mecaptobenzimidazole to form I (n = 1) and then oxidizing. x는 염소등 치환될수 있는 반응기 이며 R1, R2, R3, R4, R5, R6, R7, R8은 1항에 준한다.x is a reactive group such as chlorine, and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 comply with Clause 1. 다음 구조식(Ⅲ)의 벤즈이미다졸릴아세트산 유도체와 다음 구조식(V)의 아닐린 유도체의 축합반응을 통하여 합성된 I (n=0)을 산화하여 I (n=1)을 제조하는 방법.A method of preparing I (n = 1) by oxidizing I (n = 0) synthesized through a condensation reaction of a benzimidazolyl acetic acid derivative of formula (III) with an aniline derivative of formula (V). Y는 히드록시기를 포함하여 축합반응을 통하여 반응할수 있는 반응성기이며, R1, R2, R3, R4, R5, R6, R7, R8은 1항에 준한다.Y is a reactive group capable of reacting through condensation reaction including a hydroxyl group, and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 comply with Clause 1. 다음 구조식(I)로 표시되는 벤즈이미다졸 유도체를 유효성분으로 하는 항궤양성 약제An antiulcer drug comprising as an active ingredient a benzimidazole derivative represented by the following structural formula (I) 상기식에서 R1, R2, R3, R4, R5는 각각 서로 같거나 다른 것으로서 수소원자, 할로겐원자, 탄소수 1~6개의 저급 알킬, 시클로알킬, 또는 탄소수 1-6개의 저급 알콕시기, 치환되거나 치환되지 않은 페녹시기, 또는 치환되지 않은 아미노기들이다. R6, R7은 수소원자가 바람직하나, 메칠기를 포함한 탄소수 1~4개의 저급 알킬기로 포함할수 있다. R8은 수소, 메칠기를 포함하여 알킬, 할로겐,알콕시등이다. n은 0 또는 1이다.Wherein R 1 , R 2 , R 3 , R 4 , R 5 are the same as or different from each other, and each hydrogen atom, halogen atom, lower alkyl having 1 to 6 carbon atoms, cycloalkyl, lower alkoxy group having 1 to 6 carbon atoms, Substituted or unsubstituted phenoxy group, or unsubstituted amino groups. R 6 and R 7 preferably have a hydrogen atom, but may include a lower alkyl group having 1 to 4 carbon atoms including a methyl group. R 8 includes hydrogen, alkyl, alkyl, halogen, alkoxy and the like. n is 0 or 1; ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930018059A 1993-09-09 1993-09-09 New benzimidazole derivatives with amide groups KR970001476B1 (en)

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Application Number Priority Date Filing Date Title
KR1019930018059A KR970001476B1 (en) 1993-09-09 1993-09-09 New benzimidazole derivatives with amide groups

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KR950008487A true KR950008487A (en) 1995-04-17
KR970001476B1 KR970001476B1 (en) 1997-02-06

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