KR950002770A - Method for extracting pinusolide from the temporal lobe and PAF-antagonist containing it as main ingredient - Google Patents

Method for extracting pinusolide from the temporal lobe and PAF-antagonist containing it as main ingredient Download PDF

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Publication number
KR950002770A
KR950002770A KR1019930013598A KR930013598A KR950002770A KR 950002770 A KR950002770 A KR 950002770A KR 1019930013598 A KR1019930013598 A KR 1019930013598A KR 930013598 A KR930013598 A KR 930013598A KR 950002770 A KR950002770 A KR 950002770A
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KR
South Korea
Prior art keywords
pinusolide
paf
present
extracting
antagonist containing
Prior art date
Application number
KR1019930013598A
Other languages
Korean (ko)
Other versions
KR100257183B1 (en
Inventor
한병훈
양현옥
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한병훈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 한병훈 filed Critical 한병훈
Priority to KR1019930013598A priority Critical patent/KR100257183B1/en
Publication of KR950002770A publication Critical patent/KR950002770A/en
Application granted granted Critical
Publication of KR100257183B1 publication Critical patent/KR100257183B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether

Abstract

본 발명은 측백엽으로부터 피누솔라이드를 추출하는 방법 및 이 피누솔라이드를 주성분으로 함유하는 PAF-길항제에 관한 것이다.The present invention relates to a method for extracting pinusolide from a white leaf and a PAF-antagonist containing this pinusolide as a main component.

본 발명자들은 측백엽(側柏葉)으로부터 PAF수용체 결합 저해 활성이 강한 유효성분을 순수분리, 동정하여 그 유효성분이 피누솔라이드라는 것을 확인하고, 이것의 새로운 활성인 PAF-수용체 결합 저해 활성을 새로이 확인하여 본 발명을 완성하였다.The present inventors purely separated and identified an active ingredient having strong PAF receptor binding inhibitory activity from the white leaf lobe, confirming that the active ingredient is pinusolide, and newly confirming its new activity, PAF-receptor binding inhibitory activity. The present invention has been completed.

본 발명의 방법에 따라, 측백엽을 헥산으로 추출하여 헥산추출물을 정제하여 피누솔라이드를 제조할 수 있으며, 이를 통상의 약제학적으로 허용되는 부형제 또는 보조제와 혼합하고 통상의 약제학적으로 사용되는 방법으로 제형화하여 상기 피누솔라이드를 유효성분으로 함유하는 PAF-길항제제를 제조할 수 있다.According to the method of the present invention, the extract of baekryeop with hexane can be purified to extract the hexane extract to prepare a pinusolide, it is mixed with a conventional pharmaceutically acceptable excipient or adjuvant and used in a conventional pharmaceutical method It can be formulated to prepare a PAF-antagonist containing the pinusolide as an active ingredient.

또한, 본 발명에 의한 상기의 제제는 국소 염증 억제효과가 있다.In addition, the above formulation according to the present invention has a local inflammation inhibitory effect.

Description

측백엽으로부터 피누솔라이드(pinusolide)를 추출하는 방법 및 이를 주성분으로 함유하는 PAF-길항제Method for extracting pinusolide from the temporal lobe and PAF-antagonist containing it as main ingredient

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

피누솔라이드를 통상의 약제학적으로 사용되는 부형제 또는 보조제와 혼합하고 통상의 약제학적으로 사용되는 방법으로 제형화하여 제조된 PAF-길항제제.A PAF-antagonist prepared by mixing pinusolide with a conventional pharmaceutically used excipient or adjuvant and formulating by a conventional pharmaceutically used method. 제1항에 있어서, 제형을 정제, 캡슐제, 시럽제, 주사제, 연고제 또는 크림제에서 선택된 제형으로 제형화한 PAF-길항제제.The PAF-antagonist according to claim 1, wherein the formulation is formulated into a formulation selected from tablets, capsules, syrups, injections, ointments or creams. 측백엽을 헥산으로 추출하여 얻어진 헥산추출물을 정제하여 피누솔라이드를 제조하는 방법.A method of preparing quinusolide by purifying the hexane extract obtained by extracting the white leaf with hexane. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930013598A 1993-07-19 1993-07-19 Method for isolating pinusolide from biota orientalis, and paf-antagonist containing pinusolide as main component KR100257183B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019930013598A KR100257183B1 (en) 1993-07-19 1993-07-19 Method for isolating pinusolide from biota orientalis, and paf-antagonist containing pinusolide as main component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019930013598A KR100257183B1 (en) 1993-07-19 1993-07-19 Method for isolating pinusolide from biota orientalis, and paf-antagonist containing pinusolide as main component

Publications (2)

Publication Number Publication Date
KR950002770A true KR950002770A (en) 1995-02-16
KR100257183B1 KR100257183B1 (en) 2000-05-15

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Application Number Title Priority Date Filing Date
KR1019930013598A KR100257183B1 (en) 1993-07-19 1993-07-19 Method for isolating pinusolide from biota orientalis, and paf-antagonist containing pinusolide as main component

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KR (1) KR100257183B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102257044B1 (en) * 2019-11-27 2021-05-27 윤태연 electric fryer

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100481684B1 (en) * 2001-12-28 2005-04-07 주식회사 엘컴사이언스 Preventives and remedies of neurodegenerative disease containing pinusolide derivatives as active ingredients
KR101055108B1 (en) * 2010-08-20 2011-08-08 (주)아모레퍼시픽 Skin compositions for exteral application containing Thujae Semen extract

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102257044B1 (en) * 2019-11-27 2021-05-27 윤태연 electric fryer

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