KR940003559A - Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components - Google Patents
Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components Download PDFInfo
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- KR940003559A KR940003559A KR1019920014040A KR920014040A KR940003559A KR 940003559 A KR940003559 A KR 940003559A KR 1019920014040 A KR1019920014040 A KR 1019920014040A KR 920014040 A KR920014040 A KR 920014040A KR 940003559 A KR940003559 A KR 940003559A
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- alkaloids
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Abstract
본 발명은 산조인으로부터 산조인알카로이드류를 추출하는 방법 및 이 추출된 산조인알카로이드류를 주성분으로 함유하는 약학적 조성물에 관한 것이다.The present invention relates to a method for extracting acidic alkaloids from acid joins and a pharmaceutical composition containing the extracted acidic alkaloids as a main component.
본 발명의 목적은 간단한 용매추출법을 사용하여 산조인으로부터 총 사이클로펩타이드 알카로이드를 높은 수율과 순도로서 추출 및 분리하는 방법을 제공하는 것이다.It is an object of the present invention to provide a method for extracting and separating total cyclopeptide alkaloids from acid joins in high yield and purity using simple solvent extraction.
본 발명은 산조인을 파쇄하고 R-헥산으로 탈지하고 부탄올을 가하고 가열처리한 후 여과한 여액을 약산성 수용액으로 추출한 후 암모니 아로 알카리성으로 조절한 후 클로로포름으로 추출하고 클로로포름 추출액을 중류하여 충산조인 알카로이드를 제조하는 방법이다.In the present invention, the acid joins are crushed, degreased with R-hexane, butanol is added and heated, the filtrate is filtered with a weakly acidic aqueous solution, and then adjusted to ammonia and alkaline. That's how.
본 발명에 따른 산조인의 알카로이드류의 과학적인 약효과 입증되었고, 본 발명을 이용하여 산조인에서 추출 및 분리된 알카로이드류를 주성분으로 하는 정신신경안정제를 개발한다면 다른 어떠한 방법보다도 경제적으로 신약개발을 성공적으로 수행할 수 있는 방법이라 할 수 있다.The scientific drug effect of alkaloids of sanjoin according to the present invention has been proved, and if the mental nerve stabilizer based on alkaloids extracted and separated from sanjoin is developed using the present invention, new drug development is more economical than any other method. It can be called a method that can be performed.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
제1도는 층산조인 알카로이드 및 용매분획후의 각각의 힉산-초산에틸층의 박층크로마토그라피이다.FIG. 1 is a thin layer chromatography of the alkaloid which is a layer acid tank and each of the nitric acid-ethyl acetate layers after solvent fractionation.
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920014040A KR940003559A (en) | 1992-08-05 | 1992-08-05 | Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920014040A KR940003559A (en) | 1992-08-05 | 1992-08-05 | Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components |
Publications (1)
Publication Number | Publication Date |
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KR940003559A true KR940003559A (en) | 1994-03-12 |
Family
ID=67147553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920014040A KR940003559A (en) | 1992-08-05 | 1992-08-05 | Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components |
Country Status (1)
Country | Link |
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KR (1) | KR940003559A (en) |
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1992
- 1992-08-05 KR KR1019920014040A patent/KR940003559A/en not_active Application Discontinuation
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