KR940003559A - Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components - Google Patents

Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components Download PDF

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Publication number
KR940003559A
KR940003559A KR1019920014040A KR920014040A KR940003559A KR 940003559 A KR940003559 A KR 940003559A KR 1019920014040 A KR1019920014040 A KR 1019920014040A KR 920014040 A KR920014040 A KR 920014040A KR 940003559 A KR940003559 A KR 940003559A
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South Korea
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alkaloids
acid
extracted
present
extracting
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KR1019920014040A
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Korean (ko)
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한병훈
한용남
김용철
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한병훈
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Priority to KR1019920014040A priority Critical patent/KR940003559A/en
Publication of KR940003559A publication Critical patent/KR940003559A/en

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  • Medicines Containing Plant Substances (AREA)

Abstract

본 발명은 산조인으로부터 산조인알카로이드류를 추출하는 방법 및 이 추출된 산조인알카로이드류를 주성분으로 함유하는 약학적 조성물에 관한 것이다.The present invention relates to a method for extracting acidic alkaloids from acid joins and a pharmaceutical composition containing the extracted acidic alkaloids as a main component.

본 발명의 목적은 간단한 용매추출법을 사용하여 산조인으로부터 총 사이클로펩타이드 알카로이드를 높은 수율과 순도로서 추출 및 분리하는 방법을 제공하는 것이다.It is an object of the present invention to provide a method for extracting and separating total cyclopeptide alkaloids from acid joins in high yield and purity using simple solvent extraction.

본 발명은 산조인을 파쇄하고 R-헥산으로 탈지하고 부탄올을 가하고 가열처리한 후 여과한 여액을 약산성 수용액으로 추출한 후 암모니 아로 알카리성으로 조절한 후 클로로포름으로 추출하고 클로로포름 추출액을 중류하여 충산조인 알카로이드를 제조하는 방법이다.In the present invention, the acid joins are crushed, degreased with R-hexane, butanol is added and heated, the filtrate is filtered with a weakly acidic aqueous solution, and then adjusted to ammonia and alkaline. That's how.

본 발명에 따른 산조인의 알카로이드류의 과학적인 약효과 입증되었고, 본 발명을 이용하여 산조인에서 추출 및 분리된 알카로이드류를 주성분으로 하는 정신신경안정제를 개발한다면 다른 어떠한 방법보다도 경제적으로 신약개발을 성공적으로 수행할 수 있는 방법이라 할 수 있다.The scientific drug effect of alkaloids of sanjoin according to the present invention has been proved, and if the mental nerve stabilizer based on alkaloids extracted and separated from sanjoin is developed using the present invention, new drug development is more economical than any other method. It can be called a method that can be performed.

Description

산초인으로부터 산초인알카로이드류를 추출하는 방법 및 이 추출된 산초인알카로이드류를 추성분으로 함유하는 약학적 제제Method for extracting alkaloids from Sanchoin and pharmaceutical preparations containing the extracted Sanchoin alkaloids as weight components

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 층산조인 알카로이드 및 용매분획후의 각각의 힉산-초산에틸층의 박층크로마토그라피이다.FIG. 1 is a thin layer chromatography of the alkaloid which is a layer acid tank and each of the nitric acid-ethyl acetate layers after solvent fractionation.

Claims (6)

산조인을 파쇄하고 n-헥산으로 탈지하고 부탄올을 가하고 가얼처 리한 후 여과한 여 액을 약산성 수용액으로 추출한 후 암모니아로 알카리성으로 조절한 후 클로로포름으로 추출하고 클로로포름 추출액을 증류하여 총 산조인 알카로이드를 제조하는 방법.Sanjoin was crushed, degreased with n-hexane, butanol was added, and the mixture was filtered, and the filtrate was extracted with a weakly acidic aqueous solution. . 제1항에서 산으로 구연산 또는 주석산을 사용하는 방법.A method of using citric acid or tartaric acid as acid in claim 1. 제1항에서 암모니아로 PH 17-11로 조절하는 방법.The method of claim 1 wherein the ammonia is adjusted to PH 17-11. 제1항에서 얻어 진 충 산조인 알카로이드를 헥산/초산에 틸,/메탄을 혼합용매에 용해시킨후 물을 가하여 두층으로 분리시킨후 상층인 헥산,/초산에틸층을 취하여 용튠를 증류하여 사이클로펩타이드 알카로이드와 아포르괸알카로이드류를 분리하는 방법.The alkaloids obtained in claim 1 are dissolved in hexane / ethyl acetate in a mixed solvent, separated into two layers by addition of water, and then the upper layer of hexane and ethyl acetate is taken to distill the yongtune to obtain a cyclopeptide alkaloid. To separate aporium alkaloids. 총산조인 알카로이드를 약제학적으로 허용되는 통상의 부형 제 또는 보조제와 혼합하고 약제학적으로 통상의 방법으로 제제화한 약학적 제제.A pharmaceutical formulation wherein the total alkaloid is mixed with a conventionally acceptable pharmaceutically acceptable excipient or adjuvant and formulated in a pharmaceutically conventional manner. 총 사이클로펩타이드 알카로이드류를 약제학적으로 허응되는 통상의 부형 제 또는 보조제와 혼합하고 약제학적으로 허용되는 통상의 방법으로 제제화한 약학적 제제.A pharmaceutical formulation wherein total cyclopeptide alkaloids are mixed with conventionally acceptable pharmaceutically acceptable excipients or adjuvants and formulated in a conventionally pharmaceutically acceptable manner. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019920014040A 1992-08-05 1992-08-05 Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components KR940003559A (en)

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KR1019920014040A KR940003559A (en) 1992-08-05 1992-08-05 Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components

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KR1019920014040A KR940003559A (en) 1992-08-05 1992-08-05 Method for extracting acid join alkaloids from acid joins and pharmaceutical preparations containing the extracted acid join alkaloids as main components

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KR940003559A true KR940003559A (en) 1994-03-12

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