KR950000163A - Use of attenuated Pseudomonas aeruginosa CFCPA 70018 for the manufacture of a therapeutic and preventive vaccine for Pseudomonas aeruginosa infections - Google Patents

Use of attenuated Pseudomonas aeruginosa CFCPA 70018 for the manufacture of a therapeutic and preventive vaccine for Pseudomonas aeruginosa infections Download PDF

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KR950000163A
KR950000163A KR1019930010280A KR930010280A KR950000163A KR 950000163 A KR950000163 A KR 950000163A KR 1019930010280 A KR1019930010280 A KR 1019930010280A KR 930010280 A KR930010280 A KR 930010280A KR 950000163 A KR950000163 A KR 950000163A
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South Korea
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pseudomonas aeruginosa
attenuated
purified
cfcpa
pharmaceutically acceptable
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KR1019930010280A
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KR970001709B1 (en
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김현수
박완제
문우상
유왕돈
유리안
노갑수
이남중
김영지
조양제
홍선표
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이종기
제일제당 주식회사
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 피셔―데블린 면역형태에 따라 타입 7의 녹농균을 순수하게 분리하여 반복적으로 순화시킴으로써 약독화시켜 수득되는 신규의 안전한 약독화 녹농균주 CFCPA 70018 균주(KCCM 10035)의 녹농균 감염증 치료제 및 예방용 백신의 제조를 위한 용도에 관한 것이다.The present invention provides a vaccine for treating and preventing Pseudomonas aeruginosa infections of a novel safe attenuated Pseudomonas aeruginosa CFCPA 70018 strain (KCCM 10035) obtained by attenuating by purely separating and repeatedly purifying Pseudomonas aeruginosa of type 7 according to the Fischer-Deblin immunomorphology. It relates to a use for the preparation of.

본 발명에서 이용되는 신규한 약독화 녹농균주 CFCPA 70018(KCCM 10035)은 독성이 없이 안전하며, 그의 세포벽 단백질 성분도 안전하면서도 우수한 항체 생성능을 나타내고, 또한 이들로 부터 구성되는 본 발명에 따르는 녹농균 감염 예방백신 및 녹농균 감염증 치료제는 피셔 면역형 7의 녹농균주에 대해서도 탁월한 방어능력 및 치료효과를 나타낸다.The novel attenuated Pseudomonas aeruginosa CFCPA 70018 (KCCM 10035) used in the present invention is safe without toxicity, its cell wall protein components are safe and exhibit excellent antibody-producing ability, and are also composed of the Pseudomonas aeruginosa infection prevention vaccine according to the present invention. And Pseudomonas aeruginosa infectious agents exhibit excellent protective and therapeutic effects against Pseudomonas aeruginosa strains of Fisher's immunotype 7.

Description

녹농균 감염증 치료제 및 예방백신을 제조하기 위한 약독화 녹농균주 CFCPA 70018의 용도Use of attenuated Pseudomonas aeruginosa CFCPA 70018 for the manufacture of a therapeutic and preventive vaccine for Pseudomonas aeruginosa infections

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (9)

피셔 면역형의 타입 7에 해당하는 녹농균주를 순수하게 분리하여 반복적으로 순화시켜 약독화시킨 안전한 약독화 녹농균주 CFCPA 70018(KCCM 10035)로부터 순수하게 분리, 정제하여 수득한 세포벽 단백질을 함유함을 특징으로 하는 녹농균 감염 예방 백신.It is characterized by containing cell wall protein obtained by purely separating and purifying the safe attenuated Pseudomonas aeruginosa CFCPA 70018 (KCCM 10035), which was purified, purified and attenuated by Pseudomonas spp. Pseudomonas aeruginosa infection prevention vaccine. 제 1 항에 있어서, 약독화 녹농균 CFCPA 70018의 LD50이 2.7×107세포 이상임을 특징으로 하는 녹농균 감염 예방 백신.The vaccine of claim 1, wherein the LD 50 of the attenuated Pseudomonas aeruginosa CFCPA 70018 is at least 2.7 × 10 7 cells. 제 1 항에 있어서, 세포벽 단백질 이외에 추가로 약제학적으로 허용되는 부형제를 함유하는 녹농균 감염 예방 백신.2. The Pseudomonas aeruginosa infection prevention vaccine according to claim 1, further comprising a pharmaceutically acceptable excipient in addition to the cell wall protein. 피셔 면역형의 타입 7에 해당하는 녹농균주를 순수하게 분리하여 반복적으로 순화시켜 약독화시킨 안전한 약독화 녹농균주 CFCPA 70018(KCCM 10035)로 부터 분리, 정제된 세포벽 단백질에 의해 유도된 녹농균에 대한 면역글로부린을 유효성분으로 함유함을 특징으로 하는 녹농균 감염증 치료제.Immune to Pseudomonas aeruginosa induced by purified cell wall proteins isolated from purified attenuated Pseudomonas aeruginosa CFCPA 70018 (KCCM 10035), which was purified, purified and attenuated by Pseudomonas spp. A treatment for Pseudomonas aeruginosa infections comprising globulin as an active ingredient. 제 4 항에 있어서, 약제학적으로 허용되는 담체와 함께 동결건조제제의 형태로 제형화된 녹농균 감염증 치료제.The agent for treating Pseudomonas aeruginosa infection according to claim 4, formulated in the form of a lyophilized preparation with a pharmaceutically acceptable carrier. 제 5항에 있어서, 약제학적으로 허용되는 담체가 만니톨, 락토즈, 사카로즈 또는 인체 알부민임을 특징으로 하는 녹농균 감염증 치료제.The agent for treating Pseudomonas aeruginosa infection according to claim 5, wherein the pharmaceutically acceptable carrier is mannitol, lactose, saccharose or human albumin. 제 4 항에 있어서, 약제학적으로 허용되는 담체와 함께 액체 제제로 제형화된 녹농균 감염증 치료제.The agent for treating Pseudomonas aeruginosa infection according to claim 4, formulated in a liquid formulation together with a pharmaceutically acceptable carrier. 제 7 항에 있어서, 약제학적으로 허용되는 담체가 생리식염수, 주사용 증류수, 인산염 완충액 또는 수산화 알루미늄임을 특징으로 하는 녹농균 감염증 치료제.8. The agent for treating Pseudomonas aeruginosa infection according to claim 7, wherein the pharmaceutically acceptable carrier is physiological saline, distilled water for injection, phosphate buffer or aluminum hydroxide. 제 4 항에 있어서, 주사제, 정제, 캅셀제, 점안제, 분무제 또는 연고제의 형태로 제형화된 녹농균 감염증 치료제.The agent for treating Pseudomonas aeruginosa infection according to claim 4, formulated in the form of an injection, tablet, capsule, eye drop, spray or ointment. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019930010280A 1993-06-07 1993-06-07 Pseudomonas infection preventing vaccines using attenuated pseudomonas cfcpa 70018 KR970001709B1 (en)

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KR970001709B1 KR970001709B1 (en) 1997-02-14

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