KR940008675A - Patch preparation for stomatitis - Google Patents

Patch preparation for stomatitis Download PDF

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Publication number
KR940008675A
KR940008675A KR1019920018282A KR920018282A KR940008675A KR 940008675 A KR940008675 A KR 940008675A KR 1019920018282 A KR1019920018282 A KR 1019920018282A KR 920018282 A KR920018282 A KR 920018282A KR 940008675 A KR940008675 A KR 940008675A
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KR
South Korea
Prior art keywords
patch
patch according
steroidal anti
matrix
inflammatory agent
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KR1019920018282A
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Korean (ko)
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KR950010146B1 (en
Inventor
정서영
정종평
김영하
Original Assignee
서정욱
한국과학기술연구원
정종평
재단법인 대한치주연구소
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Application filed by 서정욱, 한국과학기술연구원, 정종평, 재단법인 대한치주연구소 filed Critical 서정욱
Priority to KR1019920018282A priority Critical patent/KR950010146B1/en
Publication of KR940008675A publication Critical patent/KR940008675A/en
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Publication of KR950010146B1 publication Critical patent/KR950010146B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 스테로이드계 소염제-함유 친수성 중합체 매트릭스층, 비투과성 지지막 및 박리형 라이너로 구성된 구내염 치료용 패취제 및 그의 제조방법에 관한 것이다. 본 발명에 따르는 패취제는 적용 부위에 지속적으로 치료약물을 방출하여 국소적 치료효과를 장시간 유지시키며, 또한 상처부위를 타액이나 그밖의 자극으로 부터 보고하여 치료효과를 상승시킬 수 있다.The present invention relates to a patch for treating stomatitis consisting of a steroidal anti-inflammatory agent-containing hydrophilic polymer matrix layer, a non-permeable support membrane and a peelable liner, and a method for producing the same. The patch according to the present invention can continuously release the therapeutic drug to the application site to maintain the local therapeutic effect for a long time, and also increase the therapeutic effect by reporting the wound site from saliva or other stimuli.

Description

구재염 치료용 패취(patch)제Patch preparation for stomatitis

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 본 발명에 따르는 패취제의 단면도이다.1 is a cross-sectional view of a patch according to the invention.

제2도는 본 발명에 따르는 트리암시놀론 아세토나이드-함유 패취제로부터 트리암시놀론 아세토나이드의 발출율을 도시한 그래프이다.FIG. 2 is a graph showing the release rate of triamcinolone acetonide from triamcinolone acetonide-containing patch according to the present invention.

Claims (15)

스테로이드계 소염제, 친수성 중합체, 글리세린 및 시트르산을 함유하는 약제-함유 매트릭스층; 비투과성지지막; 및 박리형 라이너로 구성됨을 특징으로 하는 구내염 치료용 패취제.A drug-containing matrix layer containing a steroidal anti-inflammatory agent, a hydrophilic polymer, glycerin and citric acid; Impermeable support membrane; And a peeling agent for treating stomatitis, comprising a release liner. 제1항에 있어서, 스테로이드계 소염제가 트리암시놀론 아세토나이드. 베클로메타손 디프로피오네이트, 베타메타손, 덱사메타손, 플루오시놀론 아세토나이드, 플루오시나이드, 플루메타손, 하이드로코티손, 프레드니솔론 및 프레드니손으로 구성된 그룹중에서 선택되는 패취제.The triamcinolone acetonide of claim 1, wherein the steroidal anti-inflammatory agent is used. A patch selected from the group consisting of beclomethasone dipropionate, betamethasone, dexamethasone, fluorocinolone acetonide, fluorinide, flumethasone, hydrocortisone, prednisolone and prednisone. 제2항에 있어서, 스테로이드계 소염제가 트리암시놀론 아세토나이드인 패취제.The patch according to claim 2, wherein the steroidal anti-inflammatory agent is triamcinolone acetonide. 제1 내지3항중의 어느 하나에 있어서, 스테로이드계 소염제가 매트릭스 총 중량에 대해0.01내지 0.1중량%의 양으로 함유된 패취제.The patch according to any one of claims 1 to 3, wherein the steroidal anti-inflammatory agent is contained in an amount of 0.01 to 0.1% by weight based on the total weight of the matrix. 제1항에 있어서, 친수성 중합체가 카라야 고무, 아라비아 고무, 카복시메틸 셀룰로즈, 하이드록시 프로필메틸 셀룰로즈 및 폴리아크릴산으로 구성된 그룹중에서 선택되는 패취제.The patch of claim 1 wherein the hydrophilic polymer is selected from the group consisting of Karaya rubber, gum arabic, carboxymethyl cellulose, hydroxy propylmethyl cellulose and polyacrylic acid. 제5항에 있어서, 친수성 중합체가 카라야 고무 패취제.6. The karaya rubber patch according to claim 5, wherein the hydrophilic polymer is. 제1항, 5항 및 7항중의 어느 하나에 있어서, 친수성 중바체가 매트릭스 총중량에 대해 40내지 50중량%의 양으로 함유된 패취제.8. The patch according to any one of claims 1, 5 and 7, wherein the hydrophilic heavy polymer is contained in an amount of 40 to 50% by weight relative to the total weight of the matrix. 제1항에 있어서, 글리세린이 매트릭스 총중량에 대해 40내지 50중량%의 양으로 함유된 패취제.The patch according to claim 1, wherein the glycerin is contained in an amount of 40 to 50% by weight based on the total weight of the matrix. 제1항에 있어서, 시트르산이 친수성 중합체의 중량을 기준으로 하여 10내지 20중량%의 양으로 함유된 패취제.The patch according to claim 1, wherein the citric acid is contained in an amount of 10 to 20% by weight based on the weight of the hydrophilic polymer. 제1항에 있어서, 박리형 라이너가 실리콘지로 구성되는 패취제.The patch according to claim 1, wherein the release liner is made of silicone paper. 제1항에 있어서, 비투과성 지지막이 유드라질 RS100-기본 필름인 패취제.The patch of claim 1 wherein the non-permeable support membrane is a Eudrazyl RS100-based film. 제11항에 있어서, 유드라질 RS100-기본 필름이 트리아세틴 3내지 5중량%를 함유하는 패취제.12. The patch of claim 11 wherein the eudrazyl RS100-based film contains 3 to 5 weight percent triacetin. 제1항에 있어서, 매트릭스 층의 두께가 0.5내지 2.0mm, 비투과성 지지막의 두께가 0.05내지0.3mm 및 박리형 라이너의 두께가 0.03내지 0.05mm인 패취제.The patch according to claim 1, wherein the matrix layer has a thickness of 0.5 to 2.0 mm, a non-permeable support film having a thickness of 0.05 to 0.3 mm, and a release liner having a thickness of 0.03 to 0.05 mm. a)글리세린에 시트르산을 용해시켜 수득한 혼합용액에 스테로이드성 소염제를 하하여 현택시키고; b)생성된 현탁액에 친수성 중합체를 가하여 점성 중합체 혼합물을 수득하고; c)수득된 점성 혼합물을 박리형 라이너상에 놓고 전연시켜 균일한 두께의필름을 형성시키고; d)형성된 필름을 가열하여 중합체를 가교결합시키고; e)수득한 박리형 라이너/매트릭스 복합층의 매트릭스층상에 비투과성 지지막을 압착 피목시킴을 특징으로하여, 제1항 내지 13항중의 어느 하나에 따르는 구내염 치료용 패취제를 제조하는 방법.a) suspended in a mixed solution obtained by dissolving citric acid in glycerin by adding a steroidal anti-inflammatory agent; b) adding a hydrophilic polymer to the resulting suspension to obtain a viscous polymer mixture; c) placing the obtained viscous mixture on a release liner and leading it to form a film of uniform thickness; d) heating the formed film to crosslink the polymer; e) A method of producing a patch for treating stomatitis according to any one of claims 1 to 13, characterized in that the non-permeable support membrane is crimped onto the matrix layer of the obtained release liner / matrix composite layer. 제14항에 있어서, 단계 b)에서 혼합물의 온도를 15℃이하로 유지시키는 방법.The process of claim 14, wherein the temperature of the mixture in step b) is maintained at 15 ° C. or less. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019920018282A 1992-10-06 1992-10-06 Patch for treatment of stomatitis KR950010146B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019920018282A KR950010146B1 (en) 1992-10-06 1992-10-06 Patch for treatment of stomatitis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019920018282A KR950010146B1 (en) 1992-10-06 1992-10-06 Patch for treatment of stomatitis

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KR940008675A true KR940008675A (en) 1994-05-16
KR950010146B1 KR950010146B1 (en) 1995-09-11

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KR1019920018282A KR950010146B1 (en) 1992-10-06 1992-10-06 Patch for treatment of stomatitis

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100358081B1 (en) * 1994-12-30 2003-01-15 에스케이케미칼주식회사 Steroid anti-inflammatory agent for treatment of stomatitis
KR20030054221A (en) * 2001-12-24 2003-07-02 애경산업(주) Composite film composition for oral cavity and preparing method thereof
WO2017090902A1 (en) * 2015-11-25 2017-06-01 티비엠 주식회사 Oral hemostatic and wound-protective film
JP2018538233A (en) * 2015-11-25 2018-12-27 ティービーエム カンパニーＴｂｍ Ｃｏｍｐａｎｙ Oral hemostasis and wound protection film

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100358081B1 (en) * 1994-12-30 2003-01-15 에스케이케미칼주식회사 Steroid anti-inflammatory agent for treatment of stomatitis
KR20030054221A (en) * 2001-12-24 2003-07-02 애경산업(주) Composite film composition for oral cavity and preparing method thereof
WO2017090902A1 (en) * 2015-11-25 2017-06-01 티비엠 주식회사 Oral hemostatic and wound-protective film
JP2018538233A (en) * 2015-11-25 2018-12-27 ティービーエム カンパニーＴｂｍ Ｃｏｍｐａｎｙ Oral hemostasis and wound protection film

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Publication number Publication date
KR950010146B1 (en) 1995-09-11

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