KR940008676A - Local anesthetic-containing patches for oral cavity - Google Patents

Abstract

The present invention relates to a topical anesthetic patch for oral cavity consisting of a local anesthetic-containing hydrophilic polymer matrix layer, a non-permeable support membrane and a release liner, and a method of manufacturing the same.

Patches according to the invention continuously release the anesthetic to the site of application to maintain the local anesthetic effect for a long time.

Description

Local anesthetic-containing patch for oral cavity

Since this is an open matter, no full text was included.

1 is a cross-sectional view of a patch according to the invention.

2 is a graph showing the release rate of lidocaine from a lidocaine-containing patch according to the present invention.

3 is a graph showing the adhesion of the patch according to the invention.

4 is a graph showing the anesthetic effect of the patch according to the present invention.

Claims (16)

A drug-containing matrix layer containing a local anesthetic, a hydrophilic polymer, glycerin and stric acid; Impermeable support membrane; And oral anesthetic-containing patch for oral cavity, characterized in that it comprises a release liner. The patch of claim 1, wherein the local anesthetic is selected from the group consisting of lidocaine and its hydrochloride, bupivacaine and its hydrochloride, ethidocaine, procaine, benzocaine, mepivacaine and prilocaine. The patch of claim 2, wherein the local anesthetic is lidocaine or lidocaine hydrochloride. The patch according to any one of claims 1 to 3, wherein the local anesthetic is contained in an amount of 30 to 40% by weight based on the total weight of the matrix. The patch of claim 1 wherein the hydrophilic polymer is selected from the group consisting of Karaya rubber, gum arabic, carboxymethyl cellulose, hydroxy propylmethyl cellulose and polyacrylic acid. The patch according to claim 5, wherein the hydrophilic polymer is karaya rubber or a mixture of karaya rubber and Carbopol 934 (polyacrylic acid). The patch according to any one of claims 1, 5 and 7, wherein the hydrophilic polymer is contained in an amount of 20 to 40% by weight relative to the total weight of the matrix. 8. The patch according to claim 7, wherein 15 to 30% by weight of caraya rubber and 9345 to 10% by weight of Carbopol are used relative to the total weight of the matrix. The patch according to claim 1, wherein the glycerin is contained in an amount of 25 to 35% by weight based on the total weight of the matrix. The patch according to claim 1, wherein the citric acid is contained in an amount of 10 to 20% by weight based on the weight of the hydrophilic polymer. The patch according to claim 1, wherein the release liner is made of silicone paper. The patch of claim 1, wherein the non-permeable support membrane is a Eudrazyl RL100 / Eudrazil S100-based film. 13. The patch of claim 12, wherein the Eudrazyl RL100 / Eudrazil S100-based film contains 4 to 10 weight percent polyethylene glycol 400. The patch according to claim 1, wherein the matrix layer has a thickness of 0.5 to 2.0 mm, a non-permeable support film having a thickness of 0.05 to 0.3 mm, and a release liner having a thickness of 0.03 to 0.05 mm. a) dissolving citric acid in glycerin; b) separately mixing the polymer with a local anesthetic; c) adding a polymer / local anesthetic mixture to the obtained glycerin / citric acid solution to obtain a viscous polymer mixture; d) placing the obtained mixture on a release liner and leading it to form a film of uniform thickness; e) heating the formed film to crosslink the polymer; f) a method of producing a topical anesthetic-containing patch for oral cavity according to any one of claims 1 to 14, characterized by compression coating a non-permeable support film on the matrix layer of the obtained release liner / matrix composite layer. . The process of claim 15, wherein the temperature of the mixture in step c) is maintained at 15 ° C. or less. ※ Note: The disclosure is based on the initial application.