KR940002229A - Method for preparing quinolone derivative - Google Patents

Method for preparing quinolone derivative Download PDF

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Publication number
KR940002229A
KR940002229A KR1019920011833A KR920011833A KR940002229A KR 940002229 A KR940002229 A KR 940002229A KR 1019920011833 A KR1019920011833 A KR 1019920011833A KR 920011833 A KR920011833 A KR 920011833A KR 940002229 A KR940002229 A KR 940002229A
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KR
South Korea
Prior art keywords
general formula
group
amino group
iii
quinolone derivative
Prior art date
Application number
KR1019920011833A
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Korean (ko)
Inventor
박상후
김찬우
Original Assignee
하기주
주식회사 코오롱
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Application filed by 하기주, 주식회사 코오롱 filed Critical 하기주
Priority to KR1019920011833A priority Critical patent/KR940002229A/en
Publication of KR940002229A publication Critical patent/KR940002229A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

본 발명은 항균력이 우수한 다음 일반식(Ⅰ)로 표시되는 퀴놀론 유도체 및 약학적으로 허용되는 그의 염의 새로운 제조방법에 관한 것이다.The present invention relates to a novel method for preparing a quinolone derivative represented by the following general formula (I) having excellent antibacterial activity and a pharmaceutically acceptable salt thereof.

본 발명은 다음 일반식(Ⅲ)의 디할로퀴놀론과 일반식 AH의 아민화합물을 일반식(Ⅲ) 또는 일반식(Ⅳ)의 화합물로 표시되는 촉매 존재하, 유기 극성용매 내에서 반응시켜서 일반식(Ⅰ)의 퀴놀론 유도체를 제조한다.The present invention is prepared by reacting a dihaloquinolone of general formula (III) with an amine compound of general formula AH in the presence of a catalyst represented by a general formula (III) or a compound of general formula (IV) in a organic polar solvent. The quinolone derivative of (I) is prepared.

상기식에서, X는 할로겐원자를 나타내고, R1은 3-옥소-2-프로파닐기, 플루오로페닐기 또는 탄소수 1-4의 저급 알킬기이며, A는 단일치환된 아미노기, 이 치환된 아미노기 또는 환상 치환된 아미노기를 나타낸다.Wherein X represents a halogen atom, R 1 is a 3-oxo-2-propanyl group, a fluorophenyl group or a lower alkyl group having 1 to 4 carbon atoms, A is a monosubstituted amino group, a substituted amino group or a cyclic substitution An amino group.

본 발명은 온화한 조건에서 짧은 시간에 고순도 및 고수율을 목적화합물(Ⅰ)을 제조할 수 있는 유용한 방법을 제공한다.The present invention provides a useful method for preparing the desired compound (I) with high purity and high yield in a short time under mild conditions.

Description

퀴놀론 유도체의 제조방법Method for preparing quinolone derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

일반식(Ⅲ)의 디할로퀴놀론과 일반식 AH의 아민화합물을 일반식(Ⅲ) 또는 일반식(Ⅳ)의 화합물로 표시되는 촉매 존재하, 유기 극성용매내에서 40-90℃에서 2-5시간 반응시킴을 특징으로 하는 일반식(Ⅰ)의 퀴놀론 유도체의 제조방법.Dihaloquinolone of formula (III) and amine compound of formula AH in the presence of a catalyst represented by a compound of formula (III) or (IV), 2-5 at 40-90 ° C. in an organic polar solvent Process for the preparation of quinolone derivatives of general formula (I), characterized by time reaction. 상기식에서, X는 할로겐원자를 나타내고, R1은 3-옥소-2-프로파닐기, 플루오로페닐기 또는 탄소수 1-4의 저급 알킬기를 나타내며, R2는 수소원자 또는 할로겐원자를 나타내며, R3는 탄소수 1-4의 저급 알킬기이며, A는 단일 치환된 아미노기, 이 치환된 아미노기 또는 환상 치환된 아미노기를 나타낸다.Wherein X represents a halogen atom, R 1 represents a 3-oxo-2-propaneyl group, a fluorophenyl group or a lower alkyl group having 1 to 4 carbon atoms, R 2 represents a hydrogen atom or a halogen atom, and R 3 Is a lower alkyl group having 1 to 4 carbon atoms, and A represents a single substituted amino group, this substituted amino group or a cyclic substituted amino group. 제1항에 있어서, 유기극성용매가 피리딘, 아세토니트릴, N-메틸피롤리돈, 디메틸술폭시드 또는 디메틸포름아미드임을 특징으로 하는 일반식(Ⅰ)의 퀴놀론 유도체의 제조방법.The method for producing a quinolone derivative of general formula (I) according to claim 1, wherein the organic polar solvent is pyridine, acetonitrile, N-methylpyrrolidone, dimethyl sulfoxide or dimethylformamide. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019920011833A 1992-07-03 1992-07-03 Method for preparing quinolone derivative KR940002229A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019920011833A KR940002229A (en) 1992-07-03 1992-07-03 Method for preparing quinolone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019920011833A KR940002229A (en) 1992-07-03 1992-07-03 Method for preparing quinolone derivative

Publications (1)

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KR940002229A true KR940002229A (en) 1994-02-16

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KR1019920011833A KR940002229A (en) 1992-07-03 1992-07-03 Method for preparing quinolone derivative

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