KR940002229A - Method for preparing quinolone derivative - Google Patents
Method for preparing quinolone derivative Download PDFInfo
- Publication number
- KR940002229A KR940002229A KR1019920011833A KR920011833A KR940002229A KR 940002229 A KR940002229 A KR 940002229A KR 1019920011833 A KR1019920011833 A KR 1019920011833A KR 920011833 A KR920011833 A KR 920011833A KR 940002229 A KR940002229 A KR 940002229A
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- KR
- South Korea
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- general formula
- group
- amino group
- iii
- quinolone derivative
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
본 발명은 항균력이 우수한 다음 일반식(Ⅰ)로 표시되는 퀴놀론 유도체 및 약학적으로 허용되는 그의 염의 새로운 제조방법에 관한 것이다.The present invention relates to a novel method for preparing a quinolone derivative represented by the following general formula (I) having excellent antibacterial activity and a pharmaceutically acceptable salt thereof.
본 발명은 다음 일반식(Ⅲ)의 디할로퀴놀론과 일반식 AH의 아민화합물을 일반식(Ⅲ) 또는 일반식(Ⅳ)의 화합물로 표시되는 촉매 존재하, 유기 극성용매 내에서 반응시켜서 일반식(Ⅰ)의 퀴놀론 유도체를 제조한다.The present invention is prepared by reacting a dihaloquinolone of general formula (III) with an amine compound of general formula AH in the presence of a catalyst represented by a general formula (III) or a compound of general formula (IV) in a organic polar solvent. The quinolone derivative of (I) is prepared.
상기식에서, X는 할로겐원자를 나타내고, R1은 3-옥소-2-프로파닐기, 플루오로페닐기 또는 탄소수 1-4의 저급 알킬기이며, A는 단일치환된 아미노기, 이 치환된 아미노기 또는 환상 치환된 아미노기를 나타낸다.Wherein X represents a halogen atom, R 1 is a 3-oxo-2-propanyl group, a fluorophenyl group or a lower alkyl group having 1 to 4 carbon atoms, A is a monosubstituted amino group, a substituted amino group or a cyclic substitution An amino group.
본 발명은 온화한 조건에서 짧은 시간에 고순도 및 고수율을 목적화합물(Ⅰ)을 제조할 수 있는 유용한 방법을 제공한다.The present invention provides a useful method for preparing the desired compound (I) with high purity and high yield in a short time under mild conditions.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920011833A KR940002229A (en) | 1992-07-03 | 1992-07-03 | Method for preparing quinolone derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920011833A KR940002229A (en) | 1992-07-03 | 1992-07-03 | Method for preparing quinolone derivative |
Publications (1)
Publication Number | Publication Date |
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KR940002229A true KR940002229A (en) | 1994-02-16 |
Family
ID=67296498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920011833A KR940002229A (en) | 1992-07-03 | 1992-07-03 | Method for preparing quinolone derivative |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR940002229A (en) |
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1992
- 1992-07-03 KR KR1019920011833A patent/KR940002229A/en not_active Application Discontinuation
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