KR930702403A - 올리고머의 고체상 합성을 위한 비-방향족 유기 중합체 시약 - Google Patents
올리고머의 고체상 합성을 위한 비-방향족 유기 중합체 시약Info
- Publication number
- KR930702403A KR930702403A KR1019930701258A KR930701258A KR930702403A KR 930702403 A KR930702403 A KR 930702403A KR 1019930701258 A KR1019930701258 A KR 1019930701258A KR 930701258 A KR930701258 A KR 930701258A KR 930702403 A KR930702403 A KR 930702403A
- Authority
- KR
- South Korea
- Prior art keywords
- polymer
- moiety
- reagent
- conjugation
- solid phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 48
- 238000010532 solid phase synthesis reaction Methods 0.000 title claims abstract description 12
- 229920000620 organic polymer Polymers 0.000 title claims 5
- 229920000642 polymer Polymers 0.000 claims abstract description 74
- 125000001263 nucleosidyl group Chemical group 0.000 claims abstract 9
- 239000000178 monomer Substances 0.000 claims 20
- 230000021615 conjugation Effects 0.000 claims 16
- 239000002904 solvent Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 230000008878 coupling Effects 0.000 claims 5
- 238000010168 coupling process Methods 0.000 claims 5
- 238000005859 coupling reaction Methods 0.000 claims 5
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical group C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 4
- -1 aliphatic ester Chemical class 0.000 claims 4
- 239000013256 coordination polymer Substances 0.000 claims 4
- 238000004132 cross linking Methods 0.000 claims 4
- 150000002148 esters Chemical group 0.000 claims 4
- 125000005641 methacryl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 231100001261 hazardous Toxicity 0.000 claims 3
- 150000003833 nucleoside derivatives Chemical group 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 229920000131 polyvinylidene Polymers 0.000 claims 3
- 239000011148 porous material Substances 0.000 claims 3
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical group CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 230000001588 bifunctional effect Effects 0.000 claims 2
- 229920002521 macromolecule Polymers 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 1
- 125000005263 alkylenediamine group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Chemical group CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Saccharide Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60584990A | 1990-10-26 | 1990-10-26 | |
| US605,849 | 1990-10-26 | ||
| US78132991A | 1991-10-18 | 1991-10-18 | |
| US781,329 | 1991-10-18 | ||
| PCT/US1991/007915 WO1992007882A1 (en) | 1990-10-26 | 1991-10-25 | Non-aromatic organic polymeric reagents for solid phase synthesis of oligomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930702403A true KR930702403A (ko) | 1993-09-09 |
Family
ID=27085074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019930701258A Ceased KR930702403A (ko) | 1990-10-26 | 1991-10-25 | 올리고머의 고체상 합성을 위한 비-방향족 유기 중합체 시약 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5723599A (enExample) |
| EP (1) | EP0554407A1 (enExample) |
| JP (1) | JPH06502667A (enExample) |
| KR (1) | KR930702403A (enExample) |
| AU (1) | AU668855B2 (enExample) |
| CA (1) | CA2094595A1 (enExample) |
| IE (1) | IE913762A1 (enExample) |
| IL (1) | IL99862A (enExample) |
| NZ (1) | NZ240354A (enExample) |
| WO (1) | WO1992007882A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994001446A2 (en) * | 1992-07-09 | 1994-01-20 | Beckman Instruments, Inc. | Derivatized organic solid support for nucleic acid synthesis |
| FR2703359B1 (fr) * | 1993-03-31 | 1995-06-23 | Cis Bio Int | Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation . |
| FR2707296B1 (fr) * | 1993-07-09 | 1995-09-29 | Genset Sa | Procédé de synthèse d'acides nucléiques sur support solide et composés utiles notamment comme support solide dans ledit procédé. |
| US6110669A (en) * | 1996-06-05 | 2000-08-29 | Milton; Raymond C. | Polymeric reagents for immobilizing biopolymers |
| US6146833A (en) * | 1997-02-11 | 2000-11-14 | Beckman Coulter, Inc. | Polymeric reagents for immobilizing biopolymers |
| US5932711A (en) * | 1997-03-05 | 1999-08-03 | Mosaic Technologies, Inc. | Nucleic acid-containing polymerizable complex |
| US6692912B1 (en) * | 1997-03-05 | 2004-02-17 | Matrix Technologies Corporation | Nucleic acid-containing polymerizable complex |
| DE19715504C2 (de) * | 1997-04-14 | 2000-10-26 | Max Planck Gesellschaft | PMMA-Membranen mit Polyethylenglykol-gekoppelten Wirksubstanzen |
| US6986902B1 (en) | 1998-04-28 | 2006-01-17 | Inex Pharmaceuticals Corporation | Polyanionic polymers which enhance fusogenicity |
| ATE331739T1 (de) * | 1998-04-28 | 2006-07-15 | Inex Pharmaceuticals Corp | Polyanionische polymere mit verbesserter fusogenfähigkeit |
| US6995259B1 (en) * | 1998-10-23 | 2006-02-07 | Sirna Therapeutics, Inc. | Method for the chemical synthesis of oligonucleotides |
| WO2000026262A2 (en) * | 1998-11-05 | 2000-05-11 | Mitokor | Functionalized polymeric substrates for binding molecular moieties |
| US6184347B1 (en) | 1998-11-19 | 2001-02-06 | Agilent Technologies Inc. | Minimization of blooming in high-density arrays by using reactive wash reagents |
| US6335438B1 (en) * | 1999-03-22 | 2002-01-01 | Geir Fonnum | Method for the manufacture of amino group containing support matrices, support matrices prepared by the method, and use of the support matrices |
| US6489466B2 (en) | 2000-01-28 | 2002-12-03 | Linden Technologies, Inc. | C-3′ protected monomeric nucleotides and synthesis of oligonucleotides on solid support |
| US20030072689A1 (en) * | 2001-08-15 | 2003-04-17 | Third Wave Technologies, Inc. | Polymer synthesizer |
| US7435390B2 (en) * | 2001-01-26 | 2008-10-14 | Third Wave Technologies, Inc. | Nucleic acid synthesizers |
| US6932943B1 (en) | 2001-01-26 | 2005-08-23 | Third Wave Technologies | Nucleic acid synthesizers |
| WO2002077194A2 (en) | 2001-03-26 | 2002-10-03 | Linden Technologies, Inc. | Polymer synthesis |
| US20020136772A1 (en) * | 2001-03-26 | 2002-09-26 | Tai-Nang Huang | Polymer synthesis |
| US7205399B1 (en) | 2001-07-06 | 2007-04-17 | Sirna Therapeutics, Inc. | Methods and reagents for oligonucleotide synthesis |
| US8129517B1 (en) | 2006-05-23 | 2012-03-06 | Integrated Dna Technologies, Inc. | Labeled solid supports for organic synthesis |
| RU2016132972A (ru) | 2014-01-28 | 2018-03-05 | Дайс Молекьюлс СВ, ЭлЭлСи | Монолиты с присоединенными распознающими соединениями, их система и их применение |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3494904A (en) * | 1968-09-18 | 1970-02-10 | Dow Chemical Co | Copolymers of ethylene and polyalkylene glycol ether esters of acrylic acids |
| US3660359A (en) * | 1970-06-05 | 1972-05-02 | Ford Motor Co | Thermoset resins with hydroxy acrylate methacrylonitrile and blocked isocyanate |
| CS153765B1 (enExample) * | 1971-10-14 | 1974-03-29 | ||
| US4070348A (en) * | 1973-07-25 | 1978-01-24 | Rohm Gmbh | Water-swellable, bead copolymer |
| US4070388A (en) * | 1975-10-14 | 1978-01-24 | E. I. Du Pont De Nemours And Company | Polymeric materials with acid end groups |
| US4138383A (en) * | 1975-11-24 | 1979-02-06 | California Institute Of Technology | Preparation of small bio-compatible microspheres |
| JPS56168623A (en) * | 1980-05-29 | 1981-12-24 | Toyo Contact Lens Co Ltd | Middle class water-containing contact lens |
| IL63220A (en) * | 1981-07-01 | 1985-09-29 | Yeda Res & Dev | Process for production of polyacrolein microspheres |
| CS226911B1 (en) * | 1981-10-28 | 1984-04-16 | Jaroslav Kahovec | Polymere polydonor komplexons and method of their manufacture polymere polydonor |
| JPS6055003A (ja) * | 1983-09-06 | 1985-03-29 | Yuki Gosei Yakuhin Kogyo Kk | 新規な固相合成用ポリマ−および該ポリマ−を用いるオリゴヌクレオチドの固相合成法 |
| GB8827812D0 (en) * | 1988-11-29 | 1988-12-29 | Vickers Plc | Improvements in/relating to polymeric compounds |
| DE3911222A1 (de) * | 1989-04-07 | 1990-10-11 | Bayer Ag | Poly(meth)acrylate mit aufgepfropften polycarbonatketten, ihre herstellung und verwendung |
| WO1994001446A2 (en) * | 1992-07-09 | 1994-01-20 | Beckman Instruments, Inc. | Derivatized organic solid support for nucleic acid synthesis |
-
1991
- 1991-10-25 IL IL9986291A patent/IL99862A/en not_active IP Right Cessation
- 1991-10-25 NZ NZ240354A patent/NZ240354A/en unknown
- 1991-10-25 EP EP92902557A patent/EP0554407A1/en not_active Withdrawn
- 1991-10-25 CA CA002094595A patent/CA2094595A1/en not_active Abandoned
- 1991-10-25 KR KR1019930701258A patent/KR930702403A/ko not_active Ceased
- 1991-10-25 AU AU89122/91A patent/AU668855B2/en not_active Ceased
- 1991-10-25 JP JP4500819A patent/JPH06502667A/ja active Pending
- 1991-10-25 IE IE376291A patent/IE913762A1/en not_active Application Discontinuation
- 1991-10-25 WO PCT/US1991/007915 patent/WO1992007882A1/en not_active Ceased
-
1995
- 1995-03-22 US US08/409,902 patent/US5723599A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ240354A (en) | 1995-03-28 |
| EP0554407A1 (en) | 1993-08-11 |
| IL99862A (en) | 1995-06-29 |
| CA2094595A1 (en) | 1992-04-27 |
| AU8912291A (en) | 1992-05-26 |
| EP0554407A4 (enExample) | 1994-04-13 |
| IL99862A0 (en) | 1992-08-18 |
| IE913762A1 (en) | 1992-05-22 |
| AU668855B2 (en) | 1996-05-23 |
| WO1992007882A1 (en) | 1992-05-14 |
| JPH06502667A (ja) | 1994-03-24 |
| US5723599A (en) | 1998-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19930426 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19961025 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19930426 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19981125 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19990226 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19981125 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |