KR930700083A - Osmotic Dosing System for Liquid Drug Delivery - Google Patents

Abstract

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Description

Osmotic Dosing System for Liquid Drug Delivery

Since this is an open matter, no full text was included.

1 is a diagram illustrating an osmotic system provided by the present invention for delivering a medicament to a use environment for medicament reception;

FIG. 2A is an opening view of FIG. 1 showing the structure of an osmotic system consisting of a sealed capsule surrounding a useful pharmaceutical formulation;

Figure 2B is a partially open view showing another product provided by the present invention in which the inner capsule is made as a unit.

Claims (15)

(a) a capsule consisting of a body and a cap connected to provide an internal lumen; (b) a liquid formulation consisting of a dose of the drug in the lumen; (c) an osmotic composition on the outer wall of the capsule; (d) a semipermeable composition surrounding the osmotic composition; And (e) one or more orifices penetrating the exterior and lumen to deliver the pharmaceutical formulation from the osmotic system, wherein the osmotic system is adapted to deliver the pharmaceutical formulation at a controlled rate to the fluid environment of use. The osmotic system for drug delivery according to claim 1, wherein the medicament is a calcium channel blocker or angiotensin converting enzyme inhibitor. The method of claim 1, wherein the medicament is ricinopril, diltiazem, captopril, ramipril, posinopril, benazepril, ribenzapril, silazapril, silazaprilat, perindopril, zofeno An osmotic system for delivery of a pharmaceutical formulation which is selected from the group consisting of prills, enalapril, imidapril, spirapril, lenthiapril, delaapril, allindapril, indolapril, imidapril and quinapril. (a) a wall at least partially composed of a semipermeable composition; (b) a layer consisting of an osmotic polymer composition surrounded by the wall; (c) a capsule consisting of a body and a mating cap superimposed and connected to provide a lumen surrounded by the layer; (d) a liquid formulation consisting of a therapeutically effective drug at a dosage in the lumen; And (e) an osmotic system for delivering a pharmaceutical formulation consisting of at least one orifice through the exterior and lumen of the osmotic system to deliver a therapeutically effective drug from the osmotic system at a controlled rate to the fluid environment of use. The pharmaceutical composition of claim 4, wherein the medicament is risanopril, ramipril, enalapril, captopril, enalapril, famotidine, cimetidine, ranitidine, nazatidine, sucralate, ethyntidine, nimodipine, nini Delivering a pharmaceutical formulation at a controlled rate that is selected from the group consisting of trendydipine, nisoldipine, nicardipine, parodipine, lidofazine, thiapamil, galopamill, amlodipine, diltiazem and myopazine Osmosis system. (a) a wall at least partially made of a semipermeable composition that remains substantially intact in the environment of use and is permeable to passage of fluid present in the environment of use and substantially impermeable to passage of a medicament; (b) a layer consisting of an osmotically effective solute surrounded by said wall; (c) a one-piece capsule consisting of a lumen surrounded by said layer; (d) a liquid formulation consisting of a pharmaceutical formulation in the lumen; And (e) at least one orifice that penetrates the exterior and lumen of the osmotic system to deliver the pharmaceutical formulation from the osmotic system. The luminal monoglyceride, propylene glycol monoester, succinylated monoglyceride, acetylated monoglyceride, glyceryl monostearate, monoglyceride oil emulsion, hydrogenated palm oil, hydrogenated palm oil stearin, hydrogenated soybean oil, hydrogenated An osmotic system for delivering a pharmaceutical formulation at a controlled rate that is selected from the group consisting of vegetable oils, hydrogenated cottonseed oils, partially hydrogenated oils, and blends of hydrogenated and partially hydrogenated oils. According to claim 6, wherein the lumen is vegetable oil, animal oil, marine oil, corn oil, almond oil, babass oil, eucalyptus oil, cottonseed oil, palm oil, peanut oil, tung oil, whale oil, herring oil, sunflower seed oil, rapeseed oil And an osmotic system for delivering a pharmaceutical formulation at a rate comprised from the group consisting of peppermint oil and mineral oil. 7. An osmotic system according to claim 6, wherein said lumen is selected from the group consisting of emulsions, sols, colloids, suspensions, solutions, liquids and immiscible liquids. (a) a wall of a composition permeable to fluid passage and impermeable to passage of a medicament; (b) a layer consisting of an osmotic polymer surrounded by the wall; (c) a one-piece capsule consisting of a lumen surrounded by said layer; (d) a liquid formulation consisting of a drug in the lumen; And (e) an osmotic system for delivering the pharmaceutical formulation at a controlled rate to a use fluid environment consisting of one or more orifices penetrating the exterior and lumen of the osmotic system to deliver the medication from the osmotic system. The osmotic system of claim 10, wherein said orifice is molten to deliver a pharmaceutical formulation at a controlled rate that is formed when the osmotic system is in the environment of use. The osmotic system according to claim 10, wherein said lumen is at a controlled rate consisting of a surface active agent selected from the group consisting of nonionic, cationic and anionic surface active agents. 11. An osmotic system according to claim 10, wherein said lumen is delivered at a controlled rate of said antioxidant. The osmotic system according to claim 10, wherein the medicament is a drug and the lumen is at a controlled rate consisting of 0.05 ng to 5 g of the drug. The osmotic system according to claim 10, wherein the medicament is a drug and the drug is mixed with a pharmaceutically acceptable carrier consisting of a fluid selected from the group consisting of organic and inorganic fluids. ※ Note: The disclosure is based on the initial application.