KR930007973A - 저장성 단백질 용액 - Google Patents

저장성 단백질 용액 Download PDF

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Publication number
KR930007973A
KR930007973A KR1019920019333A KR920019333A KR930007973A KR 930007973 A KR930007973 A KR 930007973A KR 1019920019333 A KR1019920019333 A KR 1019920019333A KR 920019333 A KR920019333 A KR 920019333A KR 930007973 A KR930007973 A KR 930007973A
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KR
South Korea
Prior art keywords
solution
buffer
hypotonic
protein solution
mol
Prior art date
Application number
KR1019920019333A
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English (en)
Inventor
프란켄 노어베르트
호이레 니콜라스
파페르트 군터
Original Assignee
다움·베버
뵈링거 만하임 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 다움·베버, 뵈링거 만하임 게엠베하 filed Critical 다움·베버
Publication of KR930007973A publication Critical patent/KR930007973A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)

Abstract

본 발명은 pH치 5.0에서 6.5를 지니는 것으로, 그리고 이 pH치가 농도 40에서 100mmol/1 및 0.05에서 1.0mol/1의 마그네슘 아스파테이트를 지니는 유기 완충물질로 조정되는 것으로 특징지워지는 저장성 POD 컨쥬게이트 용액을 제공해준다.

Description

저장성 단백질 용액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. pH치 5.0에서 6.5를 지니는 것으로, 그리고 이 pH치가 농도 40에서 100mmol/1 및 0.05에서 1.0mol/1의 마그네슘 아스파테이트를 지니는 유기 완충물질로 조정되는 것으로 특징지워지는 저장성 POD 컨쥬게이트 용액(storalble POD Conjugate solution).
  2. 제1항에 있어서, 완충물질로서, 굿 완충제(good buffer), 시트레이트 완충액 및/또는 2-(N-모폴리노)-탄술폰산(MES)을 포함하는 용액.
  3. 제2항에 있어서, 완충액으로서 MES를 포함하는 용액.
  4. 전기한 항중 어느 한 항에 있어서, 최소한 하나의 안정제, 보존제 및/또는 불활성 단백질을 부가적으로 함유하는 용액.
  5. 제4항에 있어서, 0에서 0.4g/ℓ의 안정제를 포함하는 용액.
  6. 제4항 또는 5항에 있어서, 0에서 1g/ℓ의 보존제를 포함하는 용액.
  7. 제4항 내지 6항중 어느 한 항에 있어서, 0에서 20g/ℓ의 불활성 단백질을 포함하는 용액.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920019333A 1991-10-28 1992-10-21 저장성 단백질 용액 KR930007973A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4135542.3 1991-10-28
DE4135542A DE4135542A1 (de) 1991-10-28 1991-10-28 Lagerfaehige proteinloesungen

Publications (1)

Publication Number Publication Date
KR930007973A true KR930007973A (ko) 1993-05-20

Family

ID=6443602

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920019333A KR930007973A (ko) 1991-10-28 1992-10-21 저장성 단백질 용액

Country Status (9)

Country Link
EP (1) EP0539923B1 (ko)
JP (1) JP2615325B2 (ko)
KR (1) KR930007973A (ko)
AT (1) ATE133262T1 (ko)
AU (1) AU640090B2 (ko)
CA (1) CA2080971C (ko)
DE (2) DE4135542A1 (ko)
DK (1) DK0539923T3 (ko)
ES (1) ES2082326T3 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4206932A1 (de) * 1992-03-05 1993-09-09 Boehringer Mannheim Gmbh Immunologische methode zur bestimmung eines haemoglobinderivates
CN1055933C (zh) * 1995-05-09 2000-08-30 中国科学院上海有机化学研究所 一种多克隆抗体、制备方法及其用途
EP1525889A1 (en) 2000-05-15 2005-04-27 F. Hoffmann-La Roche Ag Liquid pharmaceutical composition containing an erythropoietin derivative

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7610608A (nl) * 1976-09-24 1978-03-29 Akzo Nv Werkwijze voor het stabiliseren van peroxidase- -bevattende composities.
DE3044454C2 (de) * 1980-11-26 1982-12-09 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisierte Enzymzubereitung
JPS5886083A (ja) * 1981-11-12 1983-05-23 Wako Pure Chem Ind Ltd グリセロ−ル−３−リン酸オキシダ−ゼの安定化剤
JPS6255081A (ja) * 1985-09-05 1987-03-10 Toyobo Co Ltd 安定なキサンチン酸化酵素組成物
DE3726634A1 (de) * 1987-08-11 1989-02-23 Biotest Ag Stabilisiertes peroxidasepraeparat
DE3829001A1 (de) * 1988-08-26 1990-07-05 Trigon Chemie Gmbh Asparaginsaeure-derivate und verfahren zu ihrer herstellung
FR2653782B1 (fr) * 1989-10-30 1992-02-07 Cis Bio Int Composition de peroxydase stabilisee, utilisable pour des essais immuno-enzymatiques.
US5231004A (en) * 1990-05-11 1993-07-27 Eastman Kodak Company Use of heme-containing proteins as stabilizers for enzyme-labeled immunoreactants
ES2148144T3 (es) * 1990-11-20 2000-10-16 Dade Behring Marburg Gmbh Procedimiento para la estabilizacion de conjugados de enzima.

Also Published As

Publication number Publication date
DE4135542A1 (de) 1993-04-29
DE59205094D1 (de) 1996-02-29
AU2633492A (en) 1993-04-29
ES2082326T3 (es) 1996-03-16
JPH06141860A (ja) 1994-05-24
CA2080971A1 (en) 1993-04-29
EP0539923A1 (de) 1993-05-05
CA2080971C (en) 1996-07-09
ATE133262T1 (de) 1996-02-15
AU640090B2 (en) 1993-08-12
JP2615325B2 (ja) 1997-05-28
DK0539923T3 (da) 1996-06-03
EP0539923B1 (de) 1996-01-17

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