CA2080971A1 - Storable protein solution - Google Patents

Storable protein solution

Info

Publication number
CA2080971A1
CA2080971A1 CA2080971A CA2080971A CA2080971A1 CA 2080971 A1 CA2080971 A1 CA 2080971A1 CA 2080971 A CA2080971 A CA 2080971A CA 2080971 A CA2080971 A CA 2080971A CA 2080971 A1 CA2080971 A1 CA 2080971A1
Authority
CA
Canada
Prior art keywords
storable
protein solution
aconcentration
mmol
mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2080971A
Other languages
French (fr)
Other versions
CA2080971C (en
Inventor
Norbert Franken
Nicholas Hoyle
Gunter Pappert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2080971A1 publication Critical patent/CA2080971A1/en
Application granted granted Critical
Publication of CA2080971C publication Critical patent/CA2080971C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)

Abstract

The present invention provides a storable POD
conjugate solution, characterised by a pH value of 5,0 to 6.5, adjusted by means of an organic buffer substance with aconcentration of 40 to 100 mmol/l, and 0.05 to 1.0 mol/l magnesium aspartate.
CA002080971A 1991-10-28 1992-10-20 Storable protein solution Expired - Fee Related CA2080971C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4135542.3 1991-10-28
DE4135542A DE4135542A1 (en) 1991-10-28 1991-10-28 STORAGE PROTEIN SOLUTIONS

Publications (2)

Publication Number Publication Date
CA2080971A1 true CA2080971A1 (en) 1993-04-29
CA2080971C CA2080971C (en) 1996-07-09

Family

ID=6443602

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002080971A Expired - Fee Related CA2080971C (en) 1991-10-28 1992-10-20 Storable protein solution

Country Status (9)

Country Link
EP (1) EP0539923B1 (en)
JP (1) JP2615325B2 (en)
KR (1) KR930007973A (en)
AT (1) ATE133262T1 (en)
AU (1) AU640090B2 (en)
CA (1) CA2080971C (en)
DE (2) DE4135542A1 (en)
DK (1) DK0539923T3 (en)
ES (1) ES2082326T3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4206932A1 (en) * 1992-03-05 1993-09-09 Boehringer Mannheim Gmbh IMMUNOLOGICAL METHOD FOR DETERMINING A HAEMOGLOBIN DERIVATIVE
CN1055933C (en) * 1995-05-09 2000-08-30 中国科学院上海有机化学研究所 Polyclonal antibody, preparing process and use thereof
DK1311285T4 (en) 2000-05-15 2017-07-24 Hoffmann La Roche Liquid pharmaceutical composition containing an erythropoietin derivative

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7610608A (en) * 1976-09-24 1978-03-29 Akzo Nv PROCESS FOR STABILIZING PEROXIDASE-CONTAINING COMPOSITIONS.
DE3044454C2 (en) * 1980-11-26 1982-12-09 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilized enzyme preparation
JPS5886083A (en) * 1981-11-12 1983-05-23 Wako Pure Chem Ind Ltd Stabilizing agent for glycerol-3-phosphoric acid oxidase
JPS6255081A (en) * 1985-09-05 1987-03-10 Toyobo Co Ltd Stable xanthine oxidase composition
DE3726634A1 (en) * 1987-08-11 1989-02-23 Biotest Ag STABILIZED PEROXIDASE PREPARATION
DE3829001A1 (en) * 1988-08-26 1990-07-05 Trigon Chemie Gmbh ASPARAGINIC DERIVATIVES AND METHOD FOR THEIR PREPARATION
FR2653782B1 (en) * 1989-10-30 1992-02-07 Cis Bio Int STABILIZED PEROXYDASE COMPOSITION FOR USE IN IMMUNO-ENZYMATICS.
US5231004A (en) * 1990-05-11 1993-07-27 Eastman Kodak Company Use of heme-containing proteins as stabilizers for enzyme-labeled immunoreactants
CA2055812A1 (en) * 1990-11-20 1992-05-21 Carl N. Skold Method of stabilizing enzyme conjugates

Also Published As

Publication number Publication date
ATE133262T1 (en) 1996-02-15
DK0539923T3 (en) 1996-06-03
EP0539923A1 (en) 1993-05-05
ES2082326T3 (en) 1996-03-16
CA2080971C (en) 1996-07-09
JPH06141860A (en) 1994-05-24
KR930007973A (en) 1993-05-20
JP2615325B2 (en) 1997-05-28
EP0539923B1 (en) 1996-01-17
AU640090B2 (en) 1993-08-12
DE4135542A1 (en) 1993-04-29
AU2633492A (en) 1993-04-29
DE59205094D1 (en) 1996-02-29

Similar Documents

Publication Publication Date Title
OA09323A (en) "Imadazo /4, 5-b/ quinolinyloxyalkanoic acid amides with enhanced water solubility".
AU3321689A (en) Low ph shampoo containing climbazole
MX9202838A (en) IMIDAZO [1,5-A] QUINOXALINAS.
CA2147647A1 (en) Anthraquinone Inhibition of Methane Production in Methanogenic Bacteria
GR3017462T3 (en) 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists.
AU6779190A (en) N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives
ZA957726B (en) 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives
CA2036283A1 (en) Effervescent composition, its production and use
HU9201982D0 (en) Sealed, pre-assembled bearing
EP0569491A4 (en) 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
ZA927499B (en) Cyclic-substituted imidazolyl-propenoic acid derivatives.
AU1384688A (en) 1,5-substituted 1H-imidazoles
CA2080971A1 (en) Storable protein solution
TW282464B (en)
AU569925B2 (en) 2,5-diketo-d-gluconic acid reductase
PH30818A (en) Novel substituted thienopyrans as antihpertensive agents.
EP0462837A3 (en) Preparation of indole derivatives
CA2066234A1 (en) Activation compounds and methods for nucleic acid sterilization
AU8057491A (en) Aqueous coolant
EP0647991A3 (en) Boardlock clip.
AU2240388A (en) Azachromane derivatives
TW243446B (en)
EP0476156A4 (en) Solid oral preparation containing catechol compound
EP0216162A3 (en) A method of preparing indoles or indole derivatives, coupled via position 4, 5, 6, or 7, the indoles or indole derivatives concerned, as well as the use thereof
AU589745B2 (en) 2', 3', 4', 10'-tetrahydro-10'-substituted-10'-hydroxy-spiro ((cycloalkane or heterocyclic)-pyrimido(1,2a)indoles

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed