CA2080971A1 - Storable protein solution - Google Patents

Storable protein solution

Info

Publication number
CA2080971A1
CA2080971A1 CA2080971A CA2080971A CA2080971A1 CA 2080971 A1 CA2080971 A1 CA 2080971A1 CA 2080971 A CA2080971 A CA 2080971A CA 2080971 A CA2080971 A CA 2080971A CA 2080971 A1 CA2080971 A1 CA 2080971A1
Authority
CA
Canada
Prior art keywords
storable
protein solution
aconcentration
mmol
mol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2080971A
Other languages
French (fr)
Other versions
CA2080971C (en
Inventor
Norbert Franken
Nicholas Hoyle
Gunter Pappert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2080971A1 publication Critical patent/CA2080971A1/en
Application granted granted Critical
Publication of CA2080971C publication Critical patent/CA2080971C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides a storable POD
conjugate solution, characterised by a pH value of 5,0 to 6.5, adjusted by means of an organic buffer substance with aconcentration of 40 to 100 mmol/l, and 0.05 to 1.0 mol/l magnesium aspartate.
CA002080971A 1991-10-28 1992-10-20 Storable protein solution Expired - Fee Related CA2080971C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4135542.3 1991-10-28
DE4135542A DE4135542A1 (en) 1991-10-28 1991-10-28 STORAGE PROTEIN SOLUTIONS

Publications (2)

Publication Number Publication Date
CA2080971A1 true CA2080971A1 (en) 1993-04-29
CA2080971C CA2080971C (en) 1996-07-09

Family

ID=6443602

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002080971A Expired - Fee Related CA2080971C (en) 1991-10-28 1992-10-20 Storable protein solution

Country Status (9)

Country Link
EP (1) EP0539923B1 (en)
JP (1) JP2615325B2 (en)
KR (1) KR930007973A (en)
AT (1) ATE133262T1 (en)
AU (1) AU640090B2 (en)
CA (1) CA2080971C (en)
DE (2) DE4135542A1 (en)
DK (1) DK0539923T3 (en)
ES (1) ES2082326T3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4206932A1 (en) * 1992-03-05 1993-09-09 Boehringer Mannheim Gmbh IMMUNOLOGICAL METHOD FOR DETERMINING A HAEMOGLOBIN DERIVATIVE
CN1055933C (en) * 1995-05-09 2000-08-30 中国科学院上海有机化学研究所 Polyclonal antibody, preparing process and use thereof
BRPI0110914B8 (en) 2000-05-15 2021-05-25 Hoffmann La Roche 'liquid pharmaceutical composition, process for its preparation and use of a pharmaceutical composition'

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7610608A (en) * 1976-09-24 1978-03-29 Akzo Nv PROCESS FOR STABILIZING PEROXIDASE-CONTAINING COMPOSITIONS.
DE3044454C2 (en) * 1980-11-26 1982-12-09 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilized enzyme preparation
JPS5886083A (en) * 1981-11-12 1983-05-23 Wako Pure Chem Ind Ltd Stabilizing agent for glycerol-3-phosphoric acid oxidase
JPS6255081A (en) * 1985-09-05 1987-03-10 Toyobo Co Ltd Stable xanthine oxidase composition
DE3726634A1 (en) * 1987-08-11 1989-02-23 Biotest Ag STABILIZED PEROXIDASE PREPARATION
DE3829001A1 (en) * 1988-08-26 1990-07-05 Trigon Chemie Gmbh ASPARAGINIC DERIVATIVES AND METHOD FOR THEIR PREPARATION
FR2653782B1 (en) * 1989-10-30 1992-02-07 Cis Bio Int STABILIZED PEROXYDASE COMPOSITION FOR USE IN IMMUNO-ENZYMATICS.
US5231004A (en) * 1990-05-11 1993-07-27 Eastman Kodak Company Use of heme-containing proteins as stabilizers for enzyme-labeled immunoreactants
ES2148144T3 (en) * 1990-11-20 2000-10-16 Dade Behring Marburg Gmbh PROCEDURE FOR THE STABILIZATION OF ENZYME CONJUGATES.

Also Published As

Publication number Publication date
EP0539923A1 (en) 1993-05-05
EP0539923B1 (en) 1996-01-17
AU2633492A (en) 1993-04-29
DK0539923T3 (en) 1996-06-03
DE4135542A1 (en) 1993-04-29
AU640090B2 (en) 1993-08-12
ATE133262T1 (en) 1996-02-15
JP2615325B2 (en) 1997-05-28
JPH06141860A (en) 1994-05-24
CA2080971C (en) 1996-07-09
DE59205094D1 (en) 1996-02-29
ES2082326T3 (en) 1996-03-16
KR930007973A (en) 1993-05-20

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed