KR920009818A - 신규 벤조디옥솔 유도체 및 이를 함유하는 간장해 개선제 - Google Patents

신규 벤조디옥솔 유도체 및 이를 함유하는 간장해 개선제 Download PDF

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Publication number
KR920009818A
KR920009818A KR1019910021212A KR910021212A KR920009818A KR 920009818 A KR920009818 A KR 920009818A KR 1019910021212 A KR1019910021212 A KR 1019910021212A KR 910021212 A KR910021212 A KR 910021212A KR 920009818 A KR920009818 A KR 920009818A
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South Korea
Prior art keywords
group
alkyl group
substituted
acid residue
derived therefrom
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KR1019910021212A
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English (en)
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마사유끼 기무라
쇼우이찌 니시다
사게후미 다께다
구니오 호사까
Original Assignee
쯔무라 아끼라
가부시끼가이샤 쯔무라
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Priority claimed from JP32440390A external-priority patent/JPH04193828A/ja
Application filed by 쯔무라 아끼라, 가부시끼가이샤 쯔무라 filed Critical 쯔무라 아끼라
Publication of KR920009818A publication Critical patent/KR920009818A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

신규 벤조디옥솔 유도체 및 이를 함유하는 간장해 개선제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식(Ⅰ)로 나타내어지는 것이 특징인 신규의 벤조디옥솔 유도체.
    식중 A는 다음의 어느 한 기를 나타낸다.
    [여기서, X는 -CR7=(R7: 카르복실기 또는 저급알콕시카르보닐기), -N= 또는 -N+R8X'=(R8: 수소원자, 저급알킬기, 아실기 또는 (저급알콕시)카르보닐기, X' : Cl-, Br-, I-, H2PO4 -, HSO- 4푸말산 잔기, 아세트산 잔기 또는 말레인산잔기)를 나타내고, R1및 R2는 각각 저급알킬기를 나타내든가, 함께 탄소수 1-3개의 알킬렌기 또는 -CH=CH-를 나타내고, n1은 0 내지 2의 정수를 나타낸다.
    (여기서, R3는 히드록시기, 저급알콕시 또는 치환되어도 좋은 아미노기를 나타내고, R1, R2및 n1은 전술한 의미를 갖는다.)
    (여기서, Y는 단일결합, -CO- 또는 -CS-를 나타내고, R4는 카르복실기 또는 그것으로부터 유도된 기, 아미노기 또는 그것으로부터 유도된 기 또는 저급알킬티오기로 치환되어도 좋은 알킬기, 또는 R4와 YR5는 함께 -CSSCOCH2-를 형성함을 나타낸다.)
    -SR6
    (여기에서 R6는 카르복실기 또는 그것으로부터 유도된 기, 아미노기 또는 그것으로부터 유도된 기, 또는 저급알킬티오기로 치환되어도 좋은 알킬기를 나타낸다.)
  2. 하기 일반식(Ⅰ')로 나타내어지는 신규의 벤조디옥솔 유도체를 유효성분으로 함유하는 것이 특징인 간장해 개선제.
    식중 A는 다음의 어느 한 기를 나타낸다.
    [여기서, X는 -CR7=(R7: 카르복실기 또는 저급알콕시카르보닐기), -N= 또는 -N+R8X'=(R8: 수소원자, 저급알킬기, 아실기 또는 (저급알콕시)카르보닐기, X' : Cl-, Br-, I-, H2PO4 -, HSO- 4푸말산 잔기, 아세트산 잔기 또는 말레인산잔기)를 나타내고, R1및 R2는 각각 저급알킬기를 나타내든가, 함께 탄소수 1-3개의 알킬렌기 또는 -CH=CH-를 나타내고, n1은 0 내지 2의 정수를 나타낸다.
    (여기서, R3는 히드록시기, 저급알콕시 또는 치환되어도 좋은 아미노기를 나타내고, R1, R2및 n1은 전술한 의미를 갖는다.)
    (여기서, Y는 단일결합, -CO- 또는 -CS-를 나타내고, R4는 수소원자 또는 저급알콕시카르보닐 알킬기를 나타내고, R'5는 카르복실기 또는 그것으로부터 유도된 기, 아미노기 또는 그것으로부터 유도된 기 또는 저급알킬티오기나 저급알콕시 카르보닐 알킬기로 치환되어도 좋은 알킬기, 또는 R4와 YR5는 함께 -CSSCOCH2-를 형성함을 나타낸다.)
    -SR6
    (여기에서 R6는 카르복실기 또는 그것으로부터 유도된 기, 아미노기 또는 그것으로부터 유도된 기, 또는 저급알킬티오기로 치환되어도 좋은 알킬기를 나타낸다.)
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910021212A 1990-11-26 1991-11-26 신규 벤조디옥솔 유도체 및 이를 함유하는 간장해 개선제 KR920009818A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP90-324403 1990-11-26
JP32440390A JPH04193828A (ja) 1990-11-26 1990-11-26 肝障害改善治療剤
JP90-329486 1990-11-30
JP32948690 1990-11-30

Publications (1)

Publication Number Publication Date
KR920009818A true KR920009818A (ko) 1992-06-25

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KR1019910021212A KR920009818A (ko) 1990-11-26 1991-11-26 신규 벤조디옥솔 유도체 및 이를 함유하는 간장해 개선제

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US (1) US5227398A (ko)
EP (1) EP0488144A1 (ko)
KR (1) KR920009818A (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055318A1 (en) * 1998-04-29 1999-11-04 Choongwae Pharm. Co., Ltd. Dihydroxyphenyl derivatives for hepatoprotection and treatment of liver diseases
US6693126B2 (en) 2000-10-27 2004-02-17 Choongwae Pharm. Co., Ltd. Dihydroxyphenyl derivatives for hepatoprotection and treatment of liver diseases
KR100941112B1 (ko) * 2007-12-05 2010-02-10 건국대학교 산학협력단 신규４-(벤조[ｄ][１,３]다이옥솔-５-일아미노)-４-옥소부타노익 산 화합물 및 그 화합물의 페닐에탄올아민Ｎ-메틸기전달효소의 저해제로서의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA942310A (en) * 1969-07-09 1974-02-19 Mitsuo Nakashita Preparation of n-substituted 6,7-methylenedioxy-4-quinolone derivatives
BE759671A (fr) * 1969-12-01 1971-06-01 Sandoz Sa Derives de la quinazolinone, leur preparation et medicaments contenant ces derives
US3637687A (en) * 1970-04-21 1972-01-25 Smith Kline French Lab Polysubstituted as-triazino(5 6-b)indoles
HU163443B (ko) * 1970-08-26 1973-08-28
DK135044B (da) * 1971-05-06 1977-02-28 Sandoz Ag Analogifremgangsmåde til fremstilling af 4-phenyl- eller 4-(2'-thienyl)-6,7-methylendioxy-2(1H)-quinazolinoner eller -2(1H)-quinazolinthioner.
US3914428A (en) * 1973-10-26 1975-10-21 American Cyanamid Co Method of using 2-arylimino-1,3-dithietane compounds as growth promotants
US4374146A (en) * 1980-11-26 1983-02-15 Burroughs Wellcome Co. Topical inflammatory pharmaceutical formulations
GB2124211B (en) * 1982-06-25 1985-12-24 Zyma Sa Dithio compounds pharmaceutical preparations containing them and their use
US4686232A (en) * 1983-02-28 1987-08-11 Sumitomo Chemical Company, Limited Fungicidal aniline derivatives
EP0188805B1 (en) * 1984-12-26 1989-09-06 Banyu Pharmaceutical Co., Ltd. 1,3-dithiole derivatives
US4668799A (en) * 1985-05-30 1987-05-26 Banyu Pharmaceutical Co., Ltd. Anti-hepatitis and anti-cirrhotic 1,3-dithiol-2-ylidene derivatives, and pharmaceutical compositions therefor
JP2521739B2 (ja) * 1987-01-27 1996-08-07 新日本薬品株式会社 肝臓疾患治療剤
IL85066A0 (en) * 1987-01-30 1988-06-30 Schering Ag 2-imino-1,3-dithietane derivatives and pesticidal compositions containing them

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EP0488144A1 (en) 1992-06-03
US5227398A (en) 1993-07-13

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