KR920003325B1 - Whitening cosmetics - Google Patents

Abstract

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Description

Skin whitening cosmetics

The present invention relates to a cosmetic product that increases the color stability of the kojic acid compounded cosmetic product, and further enhances the skin whitening effect of yeast acid.

Yeast acid is 5-oxy-2-oxymethyl- (gamma) -pyrone obtained by culture | cultivating strains, such as Aspelgillus. In addition, this compound has a tyrosinase inhibitory activity, and a cosmetic product in which whitening fat using yeast acid as an active ingredient is disclosed is disclosed (JP-A-56-18569, JP-53-53). 3538).

In cosmetics in which whitening of yeast acid is used as an active ingredient, when yeast acid is combined with a cosmetic base to make cosmetics, the yeast acid becomes yellowish brown under conditions exposed to high temperature or light, especially when manufacturing creams and the like. It tends to be colored, and the coloring degree tends to increase with time. Therefore, it is a drawback of reducing the value as a commodity.

The inventors of the present invention specifically enclosed the yeast acid with the cyclodextrin with a cosmetic base for the purpose of preventing the coloration of the yeast acid, in particular, the phenomenon of coloration with the passage of time. It was found that when blending one, not only the colorability was remarkably improved, but also the effect of whitening the yeast acid was enhanced.

The present invention is a cosmetic product that has no colorability formed by blending cyclodextrin and yeast acid, and furthermore, a skin whitening which enhanced the skin whitening effect.

The yeast acid used for this invention is a well-known compound obtained by microorganisms, such as the genus Aspelgis, the penicillium, and the gluconobacta.

Cyclodextrins used in combination with yeast acids include α, β, γ cyclodextrins and methylcyclodextrins, but β-cyclodextrins are particularly suitable.

The cyclodextrin used in the present invention is used in an amount of about 10-0.5 parts by weight, suitably about 4-5 parts by weight, with respect to 1 part by weight of yeast acid together with yeast acid.

In addition, yeast acid may be mixed with a cyclodextrin in combination.

To encapsulate the yeast acid, cyclodextrin is dispersed in water, and the yeast acid is gradually added to the solution while stirring, and both are completely dissolved to obtain the encapsulated yeast acid. The clathrate yeast acid used for this invention may be what was lyophilized what was obtained in this way.

In this case, the amount of yeast acid relative to cyclodextrin is 10-0.5 parts by weight of cyclodextrin per yeast acid 1 relative to 10 parts by weight of cyclodextrin, and suitably cyclotaxtrin per yeast acid 1 4 parts by weight. In the present invention, the yeast acid and the cyclodextrin are separately or inclusions are combined and formulated into a common cosmetic base to form a skin cosmetic such as a lotion, a cream, an emulsion or a pack. The compounding quantity of the yeast acid or clathrate yeast acid mix | blended with these cosmetic bases is 0.01-2% (weight) as yeast acid.

For example, in a lotion, a moisturizer such as glycerin, a skin nutrient, etc. are dissolved in purified water, a preservative, a perfume, etc. are dissolved in alcohol, and both are mixed and solubilized at room temperature. In the manufacture of general cosmetics, cyclodextrin and yeast acid or clathrate yeast acid are added to the aqueous phase so as to be 0.01-2% (by weight) as yeast acid to obtain a lotion.

In the cream, purified water is added to a hydrophilic component such as glycerin, sorbet, or other moisturizing agent to form an aqueous phase, and beeswax, paraffin, micro-crystallin wax, ceresin, higher fatty acids, hardened oils such as hardened oils, waselin, lanolin, glycerin, and the like. Oily components, such as preservatives and surfactants, are added to semi-solid oils, liquid oils such as succinic acid, liquid paraffin, and various ester oils to prepare oil phase parts. In the production of a general cream obtained by heating the aqueous phase obtained in this way, gently stirring and mixing the oil phase warmed to the same temperature and emulsifying it into a cream, cyclodextrin and yeast acid or clathrate yeast acid in the aqueous phase portion Is added so as to be 0.01-2% (by weight) as yeast acid to obtain a cream.

In the emulsion, a moisturizer such as glycerin, an acid or alkali pH composition agent is added to the purified water, mixed with heat and ethanol is added to form an aqueous phase, and a solid oil such as beeswax and paraffin, semi-solid oil such as waselin and lanolin, Oily components, such as preservatives and surfactants, are added to liquid oils such as hydroparaffins and liquid paraffin and various ester oils to be mixed and heated to form an oil phase portion, and the oil phase portion is preliminarily added to the water phase portion to obtain carboxyvinyl polymer, In the production of a general emulsion containing a protective colloid such as carboxymethyl cellulose, which is uniformly emulsified with a homomixer to form an emulsion, cyclodextrin and yeast acid or clathrate yeast acid are used as yeast acid in the water phase portion. It is added to the aqueous phase so as to be 0.01-2% (weight) to obtain an emulsion.

In the pack, swelling is carried out by adding a moisturizing agent such as glycerin, a coating agent such as polyvinyl alcohol, non-gum, and the like to the purified water, and if necessary, powders such as kaolin, tark, and zinc oxide are added, and a perfume, preservative, etc. In the manufacture of a general pack mixed with ethanol dissolved in the paste to form a paste, cyclodextrin and yeast acid or clathrate yeast acid are added as 0.01-2% (by weight) as yeast acid to make a pack. .

Next, the manufacture example of the clathrate yeast acid which is an active ingredient of this invention is shown.

[Production example]

To 0.5-4 parts of β-cyclodextrin, add 1.5-12 parts of purified water, and stir gently. Next, 1 part by weight of yeast acid is added, and the mixture is stirred well until homogeneous to obtain a clathrate yeast acid.

The clathrate yeast obtained in this way is lyophilized.

Example 1

cream

Example 2

cream

Example 3

latex

Example 4

latex

Example 5

pack

Example 6

pack

Example 7

toilet water

Example 8

toilet water

1. Coloring prevention test of cyclodextrin and yeast acid or clathrate yeast acid which are active ingredients of skin whitening of the present invention

(1) sample

A. Cream which mix | blended 20% clathrate yeast acid 5% (weight) [1% as a yeast acid (weight)] manufactured by the manufacturing method example.

B. A cream containing 1% of yeast acid and 4% of β-cyclodextrin prepared in Preparation Example.

C. Cream containing 1% (by weight) yeast acid.

(2) Test method

E(색차)를 측정했다.After leaving samples A, B and C at 45 ° C. for 2 months, Nippon Denshoku Co., Ltd. Z-1001DP was used and 5 ° C. as standard product. L (Brightness), a (Red), b (Yellow) and 1% Yeast Acid Blend Cream

E (color difference) was measured.

(3) Test result

The test results are shown in Table 1 below.

TABLE 1

a,

b는 각기 시료-표품의 값이다. L,

a,

b is the value of each sample-label.

As is evident from the results in Table 1, cosmetic products (A) and (B) of the present invention are significantly less colored than cosmetics (C) in which yeast acid is blended alone.

2. Decolorization test by cultured pigment cells of cyclodextrin and yeast acid or clathrate yeast acid, which are the active ingredients of skin whitening of the present invention.

(1) sample

A: Yeast Acid

B: 20% clathrate yeast acid prepared by the preparation example

C: yeast acid + β-cyclodextrin

D: β-cyclodextrin

(2) Test method

4 × 10 ⁴ mouse melanomeric B16 cells (hereinafter referred to as B16) cells were wound per 1 petri dish, and the MEM MEM medium to which 10% fetal calf serum was added was used to Add (1) yeast acid to a concentration of 2.5 mM (Test A), (2) add 20% clathrate yeast acid prepared according to Preparation Example to be converted to 2.5 mM as yeast acid (test) B), (3) the equivalent amounts of yeast acid and β-cyclodextrin used in Test B, respectively (test D), and (4) the inclusion-beta of yeast acid using β-cyclodextrin in Test B -Add dextrin equivalent (Test District D), (5) Additive-free (Test District E), trypsin-treated by incubating for 6 days at 37 ° C in 5% CO ₂ , 95% air, Cell pellets were prepared by the support core (200 rpm, 5 minutes), and the blackness of each test zone was visually compared.

(3) Test result

Test A showed moderate discoloration compared to Test E (control).

Test strips B and C showed a clear fading, the extent was stronger than test strip A, and the pellets were white to pale yellow in color.

No fading was seen in test zone D.

From the above observation results, cyclodextrin, yeast acid, or clathrate yeast acid, which are the active ingredients of the cosmetic of the present invention, exhibit a remarkable effect of inhibiting melanin production than yeast acid alone.

Claims (2)

A skin whitening cosmetic comprising a combination of cyclodextrin and yeast acid. The cosmetics according to claim 1, wherein the skin obtained by blending the yeast acid enclosed with cyclodextrin is whitened.