KR920000767A - Method for preparing 2-phenyl-6- (pyrimidin-2-yl) pyridine derivative, intermediate compound used herein, and method for preparing same - Google Patents

Method for preparing 2-phenyl-6- (pyrimidin-2-yl) pyridine derivative, intermediate compound used herein, and method for preparing same Download PDF

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KR920000767A
KR920000767A KR1019910009373A KR910009373A KR920000767A KR 920000767 A KR920000767 A KR 920000767A KR 1019910009373 A KR1019910009373 A KR 1019910009373A KR 910009373 A KR910009373 A KR 910009373A KR 920000767 A KR920000767 A KR 920000767A
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South Korea
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compound
formula
preparing
hydrogen
chlorine
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KR1019910009373A
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Korean (ko)
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비.엘.필킹턴
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수잔 제인 젠틀
임페리알 케미칼 인더스트리스 피엘씨
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Publication of KR920000767A publication Critical patent/KR920000767A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06—Zinc compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음No content

Description

2-페닐-6-(피리미딘-2-일)피리딘 유도체의 제조방법, 여기에 사용된 중간 화합물, 및 이것의 제조방법Method for preparing 2-phenyl-6- (pyrimidin-2-yl) pyridine derivative, intermediate compound used herein, and method for preparing same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (7)

일반식(Ⅳ)의 화합물을 염화아연(Ⅱ)으로 처리하는 것으로 구성된 일반식(Ⅴ) 화합물의 제조방법.A process for preparing a compound of formula (V), comprising treating a compound of formula (IV) with zinc chloride (II). 식중, W, Y 및 Z는 서로 무관하게 수소, 염소, 불소, 알킬 또는 알콕시.Wherein W, Y and Z are independently of each other hydrogen, chlorine, fluorine, alkyl or alkoxy. 제1항에 있어서, a)일반식(Ⅷ)화합물을 리튬화시키고, b)단계(a)에서 얻은 생성물을 염화아연(Ⅱ)으로 처리하는 단계로 구성된, 일반식(Ⅴ) 화합물의 제조방법.The process for preparing a compound of formula (V) according to claim 1, comprising the steps of a) lithiating the compound of formula (VII) and b) treating the product obtained in step (a) with zinc chloride (II). . 식중, W, Y 및 Z는 상기한 바와 같으며, X는 브롬 또는 요오드.Wherein W, Y and Z are as described above and X is bromine or iodine. a)일반식(Ⅷ) 화합물을 리튬화시키고, b)단계(a)에서 만들어진 생성물을 염화아연(Ⅱ)으로 처리한뒤, c)단계(b)에서 만들어진 생성물을 적당한 촉매가 존재하는 상태에서 일반식(Ⅲ) 화합물과 반응시키는 것을 구성된 일반식(I) 화합물의 제조방법.a) lithiating the compound of formula (iii), b) treating the product produced in step (a) with zinc chloride (II), and c) subjecting the product produced in step (b) to the presence of a suitable catalyst. A method for producing a compound of formula (I), comprising reacting with a compound of formula (III). 식중, W, Y 및 Z는 서로 무관하게 수소, 염소, 불소, 알킬 또는 알콕시, R1,R2및 R3는 서로 무관하게 수소, 알킬, 할로알킬 또는 알콕시, R4,R5및 R6은 서로 무관하게 수소, 염소, 불소, 아릴, 할로알킬 또는 알콕시, 또는 R4와 R5가 서로 합쳐서 m이 3 또는 4인 일반식 -(CH2)m-폴리메틸렌 그룹을 형성한다. X는 브롬 또는 요오드.Wherein W, Y and Z are independently of each other hydrogen, chlorine, fluorine, alkyl or alkoxy, R 1 , R 2 and R 3 are independently of each other hydrogen, alkyl, haloalkyl or alkoxy, R 4 , R 5 and R 6 Irrespective of each other hydrogen, chlorine, fluorine, aryl, haloalkyl or alkoxy, or R 4 and R 5 combine with each other to form a general formula-(CH 2 ) m -polymethylene group wherein m is 3 or 4. X is bromine or iodine. 제1,2 또는 제3항에 있어서, W,Y 및 Z 모두가 수소인 방법.4. A process according to claim 1, 2 or 3 wherein both W, Y and Z are hydrogen. a)일반식(Ⅷ)화합물을 리튬화시키고, b)이렇게하여 만들어진 생성물을 취하여 염화아연(Ⅱ)과 반응시키는; 단계로 구성된 방법으로 만든 생성물.a) lithiating the general compound (b), b) taking the product thus obtained and reacting with zinc chloride (II); Product made by the method consisting of steps. 식중, W,Y 및 Z는 서로 무관하게 수소, 염소, 불소, 알킬 또는 알콕시, X는 염소 또는 브롬.Wherein W, Y and Z are independently of each other hydrogen, chlorine, fluorine, alkyl or alkoxy, X is chlorine or bromine. 일반식(Ⅴ)를 갖는 화합물.Compound having general formula (V). 식중, W,Y 및 Z는 서로 무관하게 수소, 염소, 불소, 알킬 또는 알콕시.Wherein W, Y and Z are independently of each other hydrogen, chlorine, fluorine, alkyl or alkoxy. 일반식(Ⅳ)화합물을 염화아연(Ⅱ)으로 처리하는 것으로 구성된 방법으로 만든 생성물.A product made by the process consisting of treating a compound of formula (IV) with zinc chloride (II). 식중, W,Y 및 Z는 1항과 동일함.Wherein W, Y and Z are the same as in Clause 1. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019910009373A 1990-06-11 1991-06-07 Method for preparing 2-phenyl-6- (pyrimidin-2-yl) pyridine derivative, intermediate compound used herein, and method for preparing same KR920000767A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909012974A GB9012974D0 (en) 1990-06-11 1990-06-11 Chemical process
GB9012974.3 1990-06-11

Publications (1)

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KR920000767A true KR920000767A (en) 1992-01-29

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JP (1) JPH04243875A (en)
KR (1) KR920000767A (en)
DE (1) DE4118430A1 (en)
FR (1) FR2663032A1 (en)
GB (2) GB9012974D0 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101008075B1 (en) * 2008-06-27 2011-01-13 주식회사 포스코 method for reducing coil break of hot strip

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636994A1 (en) * 1996-09-12 1998-03-19 Basf Ag Process for the preparation of (2'-fluorophenyl) -3-halopyridines
GB9626635D0 (en) 1996-12-21 1997-02-12 Zeneca Ltd Zinc reagent and synthesis
JP2001081087A (en) * 1999-09-13 2001-03-27 Sankio Chemical Co Ltd New 2-(2-pyridyl)pyrimidine derivative
US20150284380A1 (en) 2012-10-31 2015-10-08 Bayer Cropscience Ag Novel heterocyclic compounds as pest control agents

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* Cited by examiner, † Cited by third party
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PH23565A (en) * 1986-09-05 1989-08-25 Sumitomo Chemical Co Novel pyrimidinylpyrimidine derivatives and a plant disease protectant containing them as the active ingredient

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101008075B1 (en) * 2008-06-27 2011-01-13 주식회사 포스코 method for reducing coil break of hot strip

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FR2663032A1 (en) 1991-12-13
JPH04243875A (en) 1992-08-31
DE4118430A1 (en) 1991-12-12
GB9012974D0 (en) 1990-08-01
GB2250286A (en) 1992-06-03
GB9111896D0 (en) 1991-07-24

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