KR910016747A - 인돌 유도체 - Google Patents

인돌 유도체 Download PDF

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Publication number
KR910016747A
KR910016747A KR1019910004550A KR910004550A KR910016747A KR 910016747 A KR910016747 A KR 910016747A KR 1019910004550 A KR1019910004550 A KR 1019910004550A KR 910004550 A KR910004550 A KR 910004550A KR 910016747 A KR910016747 A KR 910016747A
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KR
South Korea
Prior art keywords
formula
ind
compound
compounds
quinuclidinyl
Prior art date
Application number
KR1019910004550A
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English (en)
Inventor
뵈트커 헨닝
제이프리트 크리스토프
민크 클라우스-오토
볼프 한스-페터
Original Assignee
호이만, 쉬틀러
메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 호이만, 쉬틀러, 메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁 filed Critical 호이만, 쉬틀러
Publication of KR910016747A publication Critical patent/KR910016747A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

인돌 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식(Ⅰ)의 3-(3-인돌일)-퀴뉴클리딘 및 그의 염.
    Ind-R (Ⅰ)
    상기식에서, Ind는 비치환되거나 또는 1-4-C-알킬, 트리플루오로메틸, 1-4-C-알콕시, 1-4-C-알킬티오, 불소, 염소, 히드록실, 히드록시메틸, 6-10-C-아릴옥시, 7-11-C-아르알킬옥시, 1-5-C-아실옥시, 6-10-C-아로일옥시, 1-4-C-알킬술폰일옥시, 6-10-C-아릴술포일옥시, 카르복실, 1-4-C-알콕시카르보닐 및/또는 메틸렌디옥시로 단일치환 내지 4치환된3-인돌일 그룹이고, R은 3-퀴뉴클리딘일 또는 2,3-데히드로-3-퀴뉴클리딘일이다.
  2. 일반식(Ⅰ)의 화합물 및 그이 염의 제조방법에 있어서, 일반식(Ⅱ)의 화합물을 3-퀴뉴클리디논 또는 그의 염증 하나와 반응시켜, 2,3-데히드로-3-퀴뉴클리딘일화합물(I, R=2,3-데히드로-3-퀴뉴클리딘일)을 수득하고, 필요시, 이를 환원시켜 3-퀴뉴클리딘일화합물(I, R=3-퀴뉴클리딘일)을 수득하고/하거나 그렇지 않으면 일반식(Ⅰ)에 상승하되, 하나이상의 H원자대신 제거가능한 보호 그룹을 함유하는 화합물을 이 보호그룹을 제거함으로써 일반식(Ⅰ)의 화합물로 전환시키고/시키거나 일반식(Ⅰ)의 화합물에 Ind 라디칼을 다른 Ind 라디칼로 전환시키고/시키거나 일반식(Ⅰ)의 염기를 산으로 처리함으로써 그의 염증 하나로 전환시키고/시키거나 일반식(Ⅰ)의 염기를 강 염기를 사용하여 염으로부터 유리시키는 것을 특징으로 하는 제조방법.
    Ind-H (Ⅱ)
    여기서, Ind는 특허청구범위 제1항에서 정의한 바와 같다.
  3. 일반식(Ⅰ)의 화합물 및/또는 그의 생리학적으로 허용되는 염중 하나를 적어도 1종 고체, 액체 또는 반고체 부형제 또는 보조제와 함깨 적합한 용량 형태로 전환시키는 것을 특징으로 하는 약제학적 제제의 제조방법.
  4. 일반식(Ⅰ)의 화합물 및/또는 그의 생리학적으로 허용되는 염중 하나를 함유하는 약제학적 제제.
  5. 질병을 치료하기 위한 일반식(Ⅰ)의 화합물 및/또는 그들의 생리학적으로 허용되는 염중 하나의 용도.
  6. 약품의 제조를 위한 일반식(Ⅰ)의 화합물 및/또는 그들의 생리학적으로 허용되는 염중 하나의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910004550A 1990-03-04 1991-03-22 인돌 유도체 KR910016747A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4009565.7 1990-03-04
DE4009565A DE4009565A1 (de) 1990-03-24 1990-03-24 Indolderivate

Publications (1)

Publication Number Publication Date
KR910016747A true KR910016747A (ko) 1991-11-05

Family

ID=6403022

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910004550A KR910016747A (ko) 1990-03-04 1991-03-22 인돌 유도체

Country Status (15)

Country Link
US (1) US5227386A (ko)
EP (1) EP0450345B1 (ko)
JP (1) JPH04235184A (ko)
KR (1) KR910016747A (ko)
AT (1) ATE123031T1 (ko)
AU (1) AU631303B2 (ko)
CA (1) CA2038908A1 (ko)
DE (2) DE4009565A1 (ko)
DK (1) DK0450345T3 (ko)
ES (1) ES2072467T3 (ko)
HU (1) HU207069B (ko)
IE (1) IE70661B1 (ko)
PT (1) PT97100A (ko)
TW (1) TW217411B (ko)
ZA (1) ZA912198B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9201038D0 (en) * 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
GB9314174D0 (en) * 1993-07-08 1993-08-18 American Home Prod 5-ht3-antagonists
AU2001286561B2 (en) * 2000-08-21 2007-02-08 Georgetown University 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon
DE10045112A1 (de) * 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
JP2004514722A (ja) 2000-12-01 2004-05-20 ニューロサーチ、アクティーゼルスカブ ３−置換されたキヌクリジン及びこれをニコチンアンタゴニストとして使用する方法
DE10121215A1 (de) 2001-04-30 2002-10-31 Merck Patent Gmbh Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
EP1513839B1 (en) * 2002-05-30 2006-07-26 Neurosearch A/S 3-substituted quinuclidines and their use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
AU611976B2 (en) * 1987-12-24 1991-06-27 John Wyeth & Brother Limited Aroyl urea and carbamic acid derivatives of azabicyclo compounds
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
WO1990014347A1 (en) * 1989-05-24 1990-11-29 Nippon Shinyaku Co., Ltd. Indole derivatives and medicine

Also Published As

Publication number Publication date
HUT57761A (en) 1991-12-30
DE4009565A1 (de) 1991-09-26
EP0450345A1 (de) 1991-10-09
AU631303B2 (en) 1992-11-19
AU7360991A (en) 1991-10-03
ES2072467T3 (es) 1995-07-16
JPH04235184A (ja) 1992-08-24
IE70661B1 (en) 1996-12-11
DK0450345T3 (da) 1995-08-07
DE59105550D1 (de) 1995-06-29
EP0450345B1 (de) 1995-05-24
IE910963A1 (en) 1991-09-25
TW217411B (ko) 1993-12-11
PT97100A (pt) 1991-11-29
CA2038908A1 (en) 1991-09-25
HU910972D0 (en) 1991-10-28
ATE123031T1 (de) 1995-06-15
US5227386A (en) 1993-07-13
HU207069B (en) 1993-03-01
ZA912198B (en) 1992-01-29

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