ES2072467T3 - Derivados de indol. - Google Patents

Derivados de indol.

Info

Publication number
ES2072467T3
ES2072467T3 ES91103628T ES91103628T ES2072467T3 ES 2072467 T3 ES2072467 T3 ES 2072467T3 ES 91103628 T ES91103628 T ES 91103628T ES 91103628 T ES91103628 T ES 91103628T ES 2072467 T3 ES2072467 T3 ES 2072467T3
Authority
ES
Spain
Prior art keywords
quinuclidinyl
ind
indol
derivatives
indolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91103628T
Other languages
English (en)
Inventor
Henning Dr Bottcher
Christoph Dr Seyfried
Klaus-Otto Dr Minck
Hans-Peter Prof Dr Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of ES2072467T3 publication Critical patent/ES2072467T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Abstract

LAS 3-(3-INDOLIL)-QUINUCLIDINAS CON FORMULA (I) IND-R (I) EN LA QUE IND ES UN GRUPO 3-INDOLIL SUSTITUIDO UNA A CUATRO VECES POR 1-4-C-ALQUILO, TRIFLUORMETILO, 1-4-C-ALCOXI, 1-4-C-ALQUILTIO, FLUOR, CLORO, HIDROXI, HIDROXIMETILO, 6-10-C-ARILOXI, 7-11-C-ARALQUILOXI, 1-5-C-ACILOXI, 6-10-C-AROILOXI, 1-4-C-ALQUILSULFONILOXI, 6-10-C-ARILSULFONILOXI, CARBOXI, 1-4-C-ALCOXICARBONILO Y/O METILENDIOXI Y R 3-QUINUCLIDINIL O 2, 3-DEHIDRO-3-QUINUCLIDINIL ASI COMO SUS SALES FISIOLOGICAMENTE INNOCUAS SE PUEDEN UTILIZAR COMO PSICOFARMACOS.
ES91103628T 1990-03-24 1991-03-09 Derivados de indol. Expired - Lifetime ES2072467T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4009565A DE4009565A1 (de) 1990-03-24 1990-03-24 Indolderivate

Publications (1)

Publication Number Publication Date
ES2072467T3 true ES2072467T3 (es) 1995-07-16

Family

ID=6403022

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91103628T Expired - Lifetime ES2072467T3 (es) 1990-03-24 1991-03-09 Derivados de indol.

Country Status (15)

Country Link
US (1) US5227386A (es)
EP (1) EP0450345B1 (es)
JP (1) JPH04235184A (es)
KR (1) KR910016747A (es)
AT (1) ATE123031T1 (es)
AU (1) AU631303B2 (es)
CA (1) CA2038908A1 (es)
DE (2) DE4009565A1 (es)
DK (1) DK0450345T3 (es)
ES (1) ES2072467T3 (es)
HU (1) HU207069B (es)
IE (1) IE70661B1 (es)
PT (1) PT97100A (es)
TW (1) TW217411B (es)
ZA (1) ZA912198B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9201038D0 (en) * 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
GB9314174D0 (en) * 1993-07-08 1993-08-18 American Home Prod 5-ht3-antagonists
EP1315493A4 (en) * 2000-08-21 2007-12-05 Univ Georgetown 2-3-DISUBSTITUTED QUINUCLIDINS AS MONOAMINE CARRIER MODULATORS AND THERAPEUTIC AND DIAGNOSTIC METHODS BASED THEREON
DE10045112A1 (de) * 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
ATE385497T1 (de) * 2000-12-01 2008-02-15 Neurosearch As 3-substituierte quinuclidin-derivate und deren verwendung als nikotinischen agonisten
DE10121215A1 (de) 2001-04-30 2002-10-31 Merck Patent Gmbh Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
MXPA04011858A (es) * 2002-05-30 2005-03-31 Neurosearch As Quinuclidinas sustituidas en la posicion 3 y su uso.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
AU611976B2 (en) * 1987-12-24 1991-06-27 John Wyeth & Brother Limited Aroyl urea and carbamic acid derivatives of azabicyclo compounds
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
WO1990014347A1 (en) * 1989-05-24 1990-11-29 Nippon Shinyaku Co., Ltd. Indole derivatives and medicine

Also Published As

Publication number Publication date
EP0450345A1 (de) 1991-10-09
AU631303B2 (en) 1992-11-19
CA2038908A1 (en) 1991-09-25
ZA912198B (en) 1992-01-29
AU7360991A (en) 1991-10-03
KR910016747A (ko) 1991-11-05
IE910963A1 (en) 1991-09-25
PT97100A (pt) 1991-11-29
US5227386A (en) 1993-07-13
ATE123031T1 (de) 1995-06-15
JPH04235184A (ja) 1992-08-24
EP0450345B1 (de) 1995-05-24
DE4009565A1 (de) 1991-09-26
DK0450345T3 (da) 1995-08-07
HU207069B (en) 1993-03-01
DE59105550D1 (de) 1995-06-29
HUT57761A (en) 1991-12-30
IE70661B1 (en) 1996-12-11
TW217411B (es) 1993-12-11
HU910972D0 (en) 1991-10-28

Similar Documents

Publication Publication Date Title
US5151423B1 (en) Heterocyclic n-oxide derivatives of substituted benzo(5,6)cycloheptapyridines, compositions and methods of use
ES2090048T3 (es) Derivados de xantina.
DK275488D0 (da) Indolonderivater
DK0393936T3 (da) 3-substituerede 2-oxindolderivater som antiinflammatoriske midler
ES2072467T3 (es) Derivados de indol.
SE8704952D0 (sv) Farmaceutisk komposition
FI95259C (fi) Menetelmä farmaseuttisesti aktiivisten 7-substituoitu-2-amino-3,5-dihydro-4H-pyrrolo/3,2-d/pyrimidin-4-onien valmistamiseksi
SE7811455L (sv) 2-imino-imidazolidin-derivat
IT9047999A0 (it) Derivati xantinici 1-7 sostituiti ad attivita' antiasmatica, loro sali fisiologicamente accettabili, loro composizioni farmaceutiche e procedimento per la loro preparazione.
JPS57501628A (es)
LV10098A (lv) Metilpiperazinazepina atvasinajumi to iegusana un lietosana
ES501398A0 (es) Procedimiento para la preparacion de 1,1-dioxidos de 4-hi- droxi-1,2-benzoisotiazol-3(2h)-ona
DE69129238T2 (de) Okulare hypotensive homo-prostaglandinderivate
ES2059097T3 (es) Derivados de la ergolina.
IT8719801A0 (it) Procedimento per la preparazione di derivati aclhilammino furanonici e loro sali farmaceuticamentei accettabili.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 450345

Country of ref document: ES