KR910011264A - Method for preparing prostaglandins useful for medicine - Google Patents

Method for preparing prostaglandins useful for medicine Download PDF

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Publication number
KR910011264A
KR910011264A KR1019890019932A KR890019932A KR910011264A KR 910011264 A KR910011264 A KR 910011264A KR 1019890019932 A KR1019890019932 A KR 1019890019932A KR 890019932 A KR890019932 A KR 890019932A KR 910011264 A KR910011264 A KR 910011264A
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KR
South Korea
Prior art keywords
pgf
mixture
organic solvent
medicine
solvent
Prior art date
Application number
KR1019890019932A
Other languages
Korean (ko)
Other versions
KR960010102B1 (en
Inventor
박영환
김상호
박상후
박무신
Original Assignee
하기주
주식회사 코오롱
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Priority to KR1019890019932A priority Critical patent/KR960010102B1/en
Publication of KR910011264A publication Critical patent/KR910011264A/en
Application granted granted Critical
Publication of KR960010102B1 publication Critical patent/KR960010102B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음No content

Description

의약용으로 유용한 프로스타 그란딘류의 제조방법Method for preparing prostaglandins useful for medicine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (3)

프로스타그란딘 유도체중 PGF2α또는 PGE2를 분리정제하는 방법에 있어서, PGF2-모도 테트라 하이드로 퓨란, 또는 이들의 혼합물을 피리디늄 파라톨루엔 설포네이트 존재하에 유기용매중에서 탄산수소나트륨과 pH8-12로 조절하며 반응시켜서 PGF2α, PGF2또는 이들의 혼합물의 소디움염을 형성시킨후 유기용매로 추출하고, 물층을 pH2-6으로 조절하고 통상의 방법으로 처리하여 순수한 PGF2α, PGF2또는 이들의 혼합물로 정제하는 방법.Prostaglandin A method for separating and purifying the PGF 2α or PGE 2 derivatives of, PGF 2 - controlled by modo, ongjin tetrahydrofuran, or sodium hydrogen carbonate and pH8-12 in an organic solvent mixture thereof under the presence of pyridinium p-toluene sulfonate, and After the reaction to form a sodium salt of PGF 2α , PGF 2 or a mixture thereof, and extracted with an organic solvent, the water layer was adjusted to pH 2-6 and treated in a conventional manner to purified into pure PGF 2α , PGF 2 or a mixture thereof How to. 제1항에서 염 형성 유기용매로 탄소수 1-5의 저급 알카놀을 사용하는 방법.The method of using a lower alkanol having 1 to 5 carbon atoms as a salt-forming organic solvent in claim 1. 제1항에 추출용매로 티클로로메탄, 에틸에테르, 초산에틸, 클로로포름, 벤젠, 톨루엔, 키실렌 등에서 선택된 용매 또는 용매 혼합물을 사용하는 방법.The method according to claim 1, wherein a solvent or a mixture of solvents selected from thichloromethane, ethyl ether, ethyl acetate, chloroform, benzene, toluene, xylene, and the like is used as the extraction solvent. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890019932A 1989-12-28 1989-12-28 Process for the preparation of prostaglandin for pharmaceutical KR960010102B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019890019932A KR960010102B1 (en) 1989-12-28 1989-12-28 Process for the preparation of prostaglandin for pharmaceutical

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019890019932A KR960010102B1 (en) 1989-12-28 1989-12-28 Process for the preparation of prostaglandin for pharmaceutical

Publications (2)

Publication Number Publication Date
KR910011264A true KR910011264A (en) 1991-08-07
KR960010102B1 KR960010102B1 (en) 1996-07-25

Family

ID=19293997

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890019932A KR960010102B1 (en) 1989-12-28 1989-12-28 Process for the preparation of prostaglandin for pharmaceutical

Country Status (1)

Country Link
KR (1) KR960010102B1 (en)

Also Published As

Publication number Publication date
KR960010102B1 (en) 1996-07-25

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