KR840005105A - Method for preparing pharmaceutical pyridazinone derivatives - Google Patents

Method for preparing pharmaceutical pyridazinone derivatives Download PDF

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KR840005105A
KR840005105A KR1019830002710A KR830002710A KR840005105A KR 840005105 A KR840005105 A KR 840005105A KR 1019830002710 A KR1019830002710 A KR 1019830002710A KR 830002710 A KR830002710 A KR 830002710A KR 840005105 A KR840005105 A KR 840005105A
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pyridazinone
choh
och
producing
compound according
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KR1019830002710A
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Korean (ko)
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KR860001339B1 (en
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쉬브레 앙리
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쟝 쉬브레
떼아(떼라뾔띠끄 에 아쁠리까시용) 쏘씨에떼 아노님
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음No content

Description

의약용 피리다지논류 유도체의 제조방법.Method for producing a pharmaceutical pyridazinone derivative.

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (10)

다음 일반식에 해당하는 5-아닐리멘(2H, 4H)-3-피리다지논에 의해 치환된 피리다지논 유도체의 제조방법.A method for producing a pyridazinone derivative substituted by 5-anilimene (2H, 4H) -3-pyridazinone corresponding to the following general formula. 윗식중 R1,R2,R3,R4및 R5는 각각 다음과 같다.R 1 , R 2 , R 3 , R 4 and R 5 in the above formulas are as follows. R1=H,R,CI,NO2또는 OCH3;R2=H,CI,NO2, CF3또는 OCH3;R3=H,F,CI,CH3,NO2, OCH3또는 OH;R4=H 또는 OCH3;R5=H 또는 CI, 단 동시에 모두 수소원자가 될수 없으며, R2및 R3는 -O-CH2-C-에 결합될수 있고 R6는 -CH= 또는 -CHOH-이다.R 1 = H, R, CI, NO 2 or OCH 3 ; R 2 = H, CI, NO 2 , CF 3 or OCH 3 ; R 3 = H, F, CI, CH 3 , NO 2 , OCH 3 or OH R 4 = H or OCH 3 ; R 5 = H or CI, provided that both cannot be hydrogen atoms at the same time, R 2 and R 3 can be bonded to -O-CH 2 -C- and R 6 is -CH = or- CHOH-. 제1항에 있어서 R6가 -CH=그룹인 화합물의 제조방법.The process for preparing a compound according to claim 1, wherein R 6 is —CH═group. 제1항에 있어서 R6가 -CHOH- 그룹이고, R2와 R4가 수소원자인 화합물의 제조방법.The method for producing a compound according to claim 1, wherein R 6 is a -CHOH- group and R 2 and R 4 are hydrogen atoms. 제2항에 있어서 R1가 H 또는 CI이고, R2는 H, CI 또는 CF3이며, R3가 CI, NO2가 또는 H이고, R4가 H이며 R5가 H 또는 CI인 화합물의 제조방법.The compound of claim 2, wherein R 1 is H or CI, R 2 is H, CI or CF 3 , R 3 is CI, NO 2 or H, R 4 is H and R 5 is H or CI. Manufacturing method. 제1항에 있어서 R1과 R5가 H 또는 CI이고 R2, R3및 R4가 H인 화합물의 제조방법.The method of claim 1, wherein R 1 and R 5 are H or CI and R 2 , R 3 and R 4 are H. 제1항에 있어서 다음 일반식을 갖는 4-아릴-3-아세틸-4-부타놀라이드를 극성 유기용매중에서 하이드라진 수화물과 반응시켜 R6가 -CHOH-인 화합물의 제조방법.The method for producing a compound according to claim 1, wherein R 6 is -CHOH- by reacting 4-aryl-3-acetyl-4-butanolide having the following general formula with a hydrazine hydrate in a polar organic solvent. 윗식중 R1,R2,R3,R4및 R5는 제1항과 같다.Wherein R 1 , R 2 , R 3 , R 4 and R 5 are the same as defined in claim 1. 제1항에 있어서 R6가 -CHOH-인 대응하는 일반식을 가진 4,5-디하디드로(2H)피리다지논에 대하여 탈수를 실시하여 R6가 -CH=인 화합물의 제조방법.The method for preparing a compound according to claim 1, wherein R 6 is -CH = by dehydrating a 4,5-dihadediro (2H) pyridazinone having a corresponding general formula wherein R 6 is -CHOH-. 제1항에 있어서 적어도 하나의 피리다지논 유도체의 유효량을 함유한 진정작용은 약하나 대퇴부혈류량의 상당한 증가를 일이키는 약제의 제조방법.The method of claim 1 wherein the sedation containing an effective amount of at least one pyridazinone derivative is mild but results in a significant increase in femoral blood flow. 제5항에 있어서 상기 약제가 6-메틸-5-(2′,6′-디클로로-1′-벤질리덴)(2H,4H)-3-피리다지논의 약리학적 유효량을 함유하는 약제의 제조방법.The method of claim 5, wherein the medicament contains a pharmacologically effective amount of 6-methyl-5- (2 ′, 6′-dichloro-1′-benzylidene) (2H, 4H) -3-pyridazinone. . 제8항에 있어서 상기 약제가 6-메틸-5-(2′,6′-디클로로페닐-1′-하이드록시메틸)_-4,5-디하이드로(2H)-3-피리다지논의 약리학적 유효량을 함유하는 약제의 제조방법.The pharmaceutical composition of claim 8, wherein the medicament is 6-methyl-5- (2 ', 6'-dichlorophenyl-1'-hydroxymethyl) _- 4,5-dihydro (2H) -3-pyridazinone A method for producing a medicament containing an effective amount. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830002710A 1982-06-18 1983-06-17 Process for preparation of pyridazinone derivatives KR860001339B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8210630 1982-06-18
FR8210630A FR2528837A1 (en) 1982-06-18 1982-06-18 ARYLACETYL BUTANOLIDES AND THEIR PYRIDAZINONE DERIVATIVES AS MEDICAMENTS, AND METHODS FOR THEIR MANUFACTURE

Publications (2)

Publication Number Publication Date
KR840005105A true KR840005105A (en) 1984-11-03
KR860001339B1 KR860001339B1 (en) 1986-09-15

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ID=9275129

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KR1019830002710A KR860001339B1 (en) 1982-06-18 1983-06-17 Process for preparation of pyridazinone derivatives

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JP (1) JPS5910571A (en)
KR (1) KR860001339B1 (en)
BE (1) BE897085A (en)
CH (1) CH657125B (en)
DE (1) DE3321772A1 (en)
FR (1) FR2528837A1 (en)
GB (1) GB2122195A (en)
GR (1) GR78284B (en)
IT (1) IT1194281B (en)
NL (1) NL8302087A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666902A (en) * 1983-06-20 1987-05-19 Cassella Aktiengesellschaft Tetrahydropyridazinone derivatives, processes for their preparation and their use
EP0210530A1 (en) * 1985-07-27 1987-02-04 MERCK PATENT GmbH 6-Arylalkenyl pyridazinones
JPS63220512A (en) * 1987-03-09 1988-09-13 松下電器産業株式会社 Electrode foil for electrolytic capacitor
JPH04100106U (en) * 1991-02-12 1992-08-28
JPH0776050B2 (en) * 1991-07-25 1995-08-16 実 近藤 Work transfer device

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2304977A1 (en) * 1973-02-01 1974-08-08 Basf Ag 3-Aminoaryl-5-alkyl-4,5-dihydro-6(1H)-pyridazones - prepd. by reacting 2-alkyl-3-aminoaroyl-propionic acids with hydrazines

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IT1194281B (en) 1988-09-14
FR2528837A1 (en) 1983-12-23
JPS5910571A (en) 1984-01-20
GR78284B (en) 1984-09-26
IT8321684A0 (en) 1983-06-17
GB2122195A (en) 1984-01-11
CH657125B (en) 1986-08-15
FR2528837B1 (en) 1984-12-07
GB8316516D0 (en) 1983-07-20
KR860001339B1 (en) 1986-09-15
NL8302087A (en) 1984-01-16
BE897085A (en) 1983-12-19
DE3321772A1 (en) 1983-12-22

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