KR910000119A - 약품의 조절된 방출을 위한 불균질 상호침투 중합체 망상조직체 - Google Patents

약품의 조절된 방출을 위한 불균질 상호침투 중합체 망상조직체 Download PDF

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Publication number
KR910000119A
KR910000119A KR1019890008203A KR890008203A KR910000119A KR 910000119 A KR910000119 A KR 910000119A KR 1019890008203 A KR1019890008203 A KR 1019890008203A KR 890008203 A KR890008203 A KR 890008203A KR 910000119 A KR910000119 A KR 910000119A
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South Korea
Prior art keywords
ipn
drug
hydrophilic
hydrophobic
matrix
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KR1019890008203A
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English (en)
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배유한
데루오 오까노
김성완
Original Assignee
원본미기재
유니버시티 오브 유타
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Publication of KR910000119A publication Critical patent/KR910000119A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

약품의 조절된 방풀을 위한 불균질 상호침투 중합체 망상조직체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 "케이스 1" IPN으로부터의 예상되는 방출속도론을 나타내는 그래프.
제2도는 본 발명의 "케이스 2" IPN으로부터의 예상되는 방출속도론을 나타내는 그래프.
제3도는 IPN 매트릭스로부터 약품 방출의 세가지 상을 나타내는 그래프.

Claims (13)

  1. (a) 제1중합체 물질의 매트릭스 (b) 상기 매트릭스를 통해 분산된 제2중합체물질, 여기서 상기 중합체물질의 한 가지는 친수성이고 상기 물질의 다른 것을 소수성이며, (c)는 상기 중합체물질의 한가지 또는 둘다에 용해되거나 아니면 분산된 약품으로 이루어지는 것을 특징으로 하는 약품 함유 3차원 상호 침투 중합체 망상조직체(IPN).
  2. 제1항에 있어서, 상기 제1물질은 친수성이고 상기 제2물질은 소수성인 것을 특징으로 하는 IPN.
  3. 제1항에 있어서, 상기 제1물질은 소수성이고 상기 제2물질은 친수성인 것을 특징으로 하는 IPN.
  4. 제1항에 있어서, 상기 제1물질은 내 약품의 확산계수는 D1는 상기 제2물질 내 약품의 확산계수 D2와 다른 것을 특징으로 하는 IPN.
  5. 제1항에 있어서, 상기 제1물질내 약품의 용해도 S1은 상기 제2물질내 약품의 용해도 S2와 다른 것을 특징으로 하는 IPN.
  6. 제1항에 있어서, 상기 제1물질의 상기 제2물질에 대한 중량비는 약 9:1 내지 약4:1의 범위인 것을 특징으로 하는 IPN.
  7. 제1항에 있어서, 상기 중량비는 약 6:4 내지 약 4:6의 범위인 것을 특징으로 하는 IPN.
  8. 제1항에 있어서, 상기 제1 및 제2물질의 한가지만 약품을 함유하는 것을 특징으로 하는 IPN.
  9. 제1항에 있어서, 상기 제1 및 제2물질 둘다 약품을 함유하는 것을 특징으로 하는 IPN.
  10. 제9항에 있어서, 상기 제1물질은 제1약품을 함유하고 상기 제2물질은 제2약품을 함유하는 것을 특징으로 하는 IPN.
  11. 제1항에 있어서, 친수성물질은 트리이소시아네이트와 가교 결합된 폴리에틸렌옥사이드이고 소수성물질은 에틸렌글리콜 디메타크릴레이트와 가교결합된 폴리스티렌 또는 풀리(부틸 메타크릴레이트)인 것을 특징으로 하는 IPN.
  12. 제1항에 있어서, 친수성물질은 폴리(N-N'-디메틸아크릴아미드공스틸렌)이고 소수성물질은 폴리테트라메티렌 에테르 글리콜인 것을 특징으로 하는 IPN.
  13. 제1성분을 중합하여 제1중합체 물질의 매트릭스를 얻는 단계 ; 제2성분을 중합하여 상기 매트릭스내에 제2중합체 물질을 갖는 IPN을 얻는 단계, 여기서 상기 제1 및 상기 제2물질의 한 가지는 친수성이고 상기물질의 다른 것은 소수성이며 ; 약품 용액에 침지시킴으로써 IPN에 약품을 함입시키는 단계로 이루어지는 것을 특징으로 하는 약품 함유 IPN의 제조방법.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890008203A 1988-06-14 1989-06-14 약품의 조절된 방출을 위한 불균질 상호침투 중합체 망상조직체 KR910000119A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/206,593 US4931287A (en) 1988-06-14 1988-06-14 Heterogeneous interpenetrating polymer networks for the controlled release of drugs
US206593 1988-06-14

Publications (1)

Publication Number Publication Date
KR910000119A true KR910000119A (ko) 1991-01-29

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KR1019890008203A KR910000119A (ko) 1988-06-14 1989-06-14 약품의 조절된 방출을 위한 불균질 상호침투 중합체 망상조직체

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US (1) US4931287A (ko)
KR (1) KR910000119A (ko)

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