KR900702033A - 클론된 신장염 항원 - Google Patents

클론된 신장염 항원

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KR900702033A
KR900702033A KR1019900700817A KR900700817A KR900702033A KR 900702033 A KR900702033 A KR 900702033A KR 1019900700817 A KR1019900700817 A KR 1019900700817A KR 900700817 A KR900700817 A KR 900700817A KR 900702033 A KR900702033 A KR 900702033A
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sequence
recombinant dna
functional derivative
molecule
animal
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KR1019900700817A
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에이. 스미스 잔
레이초우드리 레이크티마
엘. 나일즈 잔
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원본미기재
더 제네랄 호스피탈 코오퍼레이션
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Publication of KR900702033A publication Critical patent/KR900702033A/ko

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Abstract

내용 없음

Description

클론된 신장염 항원
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 역상 HPLC에 의해 분리된 gp330 트립신 분해 펩티드의 HPLC추적을 도시한다. 제2도는 gp330으로 부터 유도된 다섯개의 트립신 분해 펩티드의 아미노산 서열을 도시한다. 제3도는 gp330 DNA 단편(1.4, 0.6 및 0.4kb)의 제한 지도를 도시하며 23- 염기 올리고뉴클레오티드 프로브에 대한 홍성화 부위를 명시한다.

Claims (15)

  1. 하이만 신장염 항원인 gp330, 또는 그의 기능상의 유도체를 코드화하는 유전서열로 이루어지는 재조합 DNA 분자.
  2. 제1항에 있어서, 상기 유전서열이 제4도의 서열을 포함하는 것을 특징으로 하는 재조합 DNA 분자.
  3. 제1항에 있어서, 상기 유전서열이 제8도의 서열을 포함하는 것을 특징으로 하는 재조합 DNA 분자.
  4. 제1항에 있어서, 상기 유전서열이 제9도의 서열을 포함하는 것을 특징으로 하는 재조합 DNA 분자.
  5. 제1항에 있어서, 복제가능한 벡터인 것을 특징으로 하는 재조합 DNA 분자.
  6. 제5항의 벡터로 형질전환된 숙주.
  7. 실질적으로 정제되고 쥐로부터 유래한 불순물이 없는 하이만 신장염 항원 분자인 gp330, 또는 그의 기능상의 유도체.
  8. 제7항에 있어서, 제5도에 도시된 아미노산 서열로 이루어지는 것을 특징으로 하는 분자.
  9. 제7항에 있어서, 제8도에 도시된 아미노산 서열로 이루어지는 것을 특징으로 하는 분자.
  10. 제7항에 있어서, 제9도에 도시된 아미노산 서열로 이루어지는 것을 특징으로 하는 분자.
  11. (a)제5항의 벡터로 형질전환된 숙주를 얻는 단계, (b)상기 유전서열의 발현을 허용하기에 충분한 조건하에서 상기 숙주를 성장시키는 단계, 그리고 (c)상기 발현된 gp330 또는 그의 기능상의 유도체를 회수하는 단계로 이루어지는, gp330 또는 그의 기능상의 유도체의 제조방법.
  12. 동물의 LDL수용체 유전자의 유전적 이상의 검출방법으로서,(a)상기 이상을 보이는 것으로 추측되는 동물로부터 DNA를 분리하는 단계; (b)단계(a)에서 얻은 상기 DNA를 gp330 또는 그의 기능상의 유도체를 코드화하는 DNA 서열과, 혼성화 조건하에서 접촉시키는 단계; 그리고 (c)상기 gp330DNA서열과 상기 분리된 DNA와의 혼성화를 검출하는 단계로 이루어지는 방법.
  13. 제12항에 있어서, 상기 유전적 이상이 가족성 과콜레스테롤 혈증인 것을 특징으로 하는 방법.
  14. 외상을 치료하기에 유효한 양으로 존재하는 (a)gp330 또는 그의 기능상의 유도체, 및 (b)약학적으로 허용가능한 담체로 이루어지는 약학조성물을 동물에 투여하는 것으로 이루어지는 외상의 치료방법.
  15. 궤양을 방지 또는 치료하기에 효과적인 양으로 존재하는 (a)gp330 또는 그의 기능상의 유도체 및 (b)약학적으로 허용가능한 담채로 이루어지는 약학조성물을 동물에 투여하는 것으로 이루어지는, 동물의 위궤양을 방지 또는 치료하기 위한 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900700817A 1988-08-23 1989-08-23 클론된 신장염 항원 KR900702033A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23521188A 1988-08-23 1988-08-23
US235,211 1988-08-23
US31368289A 1989-02-22 1989-02-22
US313.682 1989-02-22
US396,697 1989-08-22
US07/396,697 US5208144A (en) 1988-08-23 1989-08-22 Method for detection of human dna containing the gene encoding low density lipoprotein receptor
PCT/US1989/003621 WO1990002207A1 (en) 1988-08-23 1989-08-23 Cloned nephritis antigen

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KR900702033A true KR900702033A (ko) 1990-12-05

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KR1019900700817A KR900702033A (ko) 1988-08-23 1989-08-23 클론된 신장염 항원

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Country Link
US (1) US5208144A (ko)
JP (1) JPH04500603A (ko)
KR (1) KR900702033A (ko)
AU (1) AU623930B2 (ko)
DK (1) DK27591A (ko)
FI (1) FI910852A0 (ko)
WO (1) WO1990002207A1 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723556B1 (en) * 1982-12-02 2004-04-20 Cornell Research Foundation, Inc. Nucleic acid encoding a fragment of bovine luteinizing hormone/chorionic gonadotropin receptor
US5304636A (en) * 1987-04-14 1994-04-19 Boehringer Ingelheim International Gmbh Receptor for the human rhinovirus minor group
US5603932A (en) * 1987-04-14 1997-02-18 Boehringer Ingelheim International Gmbh Receptor of the minor human rhinovirus receptor group
US5496926A (en) * 1992-01-19 1996-03-05 Yeda Research And Development Co. Ltd. Process of preparing a soluble LDL receptor
US6187548B1 (en) * 1993-05-23 2001-02-13 Rhone-Poulenc Rorer Pharmaceuticals Inc. Methods using human calcium sensor protein, fragments thereof and DNA encoding same
CA2205648A1 (en) * 1994-11-23 1996-05-30 Goran Hjalm Human calcium sensor protein, fragments thereof and dna encoding same
US5523208A (en) * 1994-11-30 1996-06-04 The Board Of Trustees Of The University Of Kentucky Method to discover genetic coding regions for complementary interacting proteins by scanning DNA sequence data banks
JP3919839B2 (ja) * 1994-11-30 2007-05-30 日本ケミファ株式会社 変性低密度リポ蛋白質受容体に対する抗体
EP1794609A2 (en) * 2004-09-27 2007-06-13 Fonar Corporation Magnetic resonance imaging system, apparatus and associated methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7907292A (nl) * 1979-10-01 1981-04-03 Bogey Bv Houder met transportinrichting voor bandvormige informatiedrager en inrichting voor het schrijven, lezen of wissen van informatie, te gebruiken met zulk een houder.
JPS60501737A (ja) * 1983-07-05 1985-10-17 チロン コ−ポレイシヨン 上皮成長因子のハイブリドdna合成
CA1263619A (en) * 1984-10-09 1989-12-05 Ryuji Marumoto Dna, production and use thereof
US4745060A (en) * 1984-12-28 1988-05-17 Board Of Regents, The University Of Texas System Methods and compositions for the detection of Familial Hypercholesterolemia
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof

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Publication number Publication date
WO1990002207A1 (en) 1990-03-08
US5208144A (en) 1993-05-04
DK27591D0 (da) 1991-02-18
DK27591A (da) 1991-02-18
FI910852A0 (fi) 1991-02-22
JPH04500603A (ja) 1992-02-06
AU4212789A (en) 1990-03-23
AU623930B2 (en) 1992-05-28

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