KR900701770A - 벤조 티아디아제핀 유도체 - Google Patents
벤조 티아디아제핀 유도체Info
- Publication number
- KR900701770A KR900701770A KR1019900701322A KR900701322A KR900701770A KR 900701770 A KR900701770 A KR 900701770A KR 1019900701322 A KR1019900701322 A KR 1019900701322A KR 900701322 A KR900701322 A KR 900701322A KR 900701770 A KR900701770 A KR 900701770A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- ethyl
- pharmaceutically acceptable
- alkyl group
- lower alkyl
- Prior art date
Links
- KAOYLRLQZXRRBD-UHFFFAOYSA-N 1,2,3-benzothiadiazepine Chemical class S1N=NC=CC2=CC=CC=C12 KAOYLRLQZXRRBD-UHFFFAOYSA-N 0.000 title claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 10
- -1 4-chlorbenzyl Chemical group 0.000 claims 6
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000003416 antiarrhythmic agent Substances 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 claims 2
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- HDOWRFHMPULYOA-UHFFFAOYSA-N piperidin-4-ol Chemical group OC1CCNCC1 HDOWRFHMPULYOA-UHFFFAOYSA-N 0.000 claims 2
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims 1
- 108010013381 Porins Proteins 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 230000003288 anthiarrhythmic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000007739 porin activity proteins Human genes 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
내용없음
Claims (5)
- 일반식[식중 R1은 저급 알킬기 또는 (R3는 수소원자, 저급 알콕시기 또는 할로겐 원자를 내고, 1개 또는 동일 혹은 상이한 2~3개 치환해도 좋다.)를 나타낸다. R2-(CH2)n또는 -(CH2)nCO2R8, n은 1~4의 정수로 R4및 R6는 동일 또는 상이한 수소 원자 또는 저급 알킬기를 나타낸다. 또 R4와 R6는 서로 결합해서 환상 구조를 형성하고 그 환상 구조 중에 다시 산소 원자 혹은 질소 원자를 포함하고 있어도 좋다, R8는 수소원자 또는 저급 알킬기를 나타낸다.]로 표시되는 벤조 티아디아제핀 유도체 및 그 약학적으로 허용되는 염.
- R1이 메틸, 벤질, 4-메톡시벤질, 4-클로르벤질, 2,4-디클로르벤질 또는 2-플루오로-4-부로모벤질, R2가 -(CH2)nNR4R6(여기에서 n은 2또는 3으로, R4및 R6는 동일 상이한 수소 원자 또는 저급 알킬기를 나타내거나, 또는 R4와 R6는 서로 결합해서 질소 원자와 함께 피롤리딘, 파레리딘, 몰포린, N메틸피레라진, 4-히드록시 피레리딘환을 형성한다, CH2CH(OH)CH2NR4R6(여기서 R4및 R6는 동일 또는 상이하며 수소 원자 또는 저급 알킬기를 나타내거나 또는 R4와 R6는 서로 결합해서 질소 원자와 함께 피롤리딘, 피페리딘, 몰포린, N-메틸 피레라진, 4-히드록시 피페리딘 환을 형성한다.) 또는 -CH2CON R4R6(여기에서 R4와 R6는 서로 결합해서 질소원자와 함께 피롤리딘, 피레리딘, 몰포린, N-메틸 피페라진, 4-히드록시 피페리딘 환을 형성한다) 또는 -CH2CON R4R6(여기에서 R4와 R6는 서로 결합해서 질소 원자와 함께 피롤리딘, 피페리딘, 몰포린, N-메틸 피페라진, 4-히드록시 피레리딘 환을 형성한다)로 표시되는 기인 청구 범위 제1항 기재의 벤조티아디아제핀 유도체 및 그 약학적으로 허용되는 염.
- R1이 메틸, 벤질, 4-메톡시 벤질, 또는 4-클로로벤질, R2가 디메틸아미노 에틸, 디메틸아미노프로필,(피롤라디노-1-일)에틸, (피페리디노-1-일)프로필, (몰포리노-1-일)에틸, (몰포리노-1-일)프로필, (4-메틸 피레라지노-1-일)프로필 [2-옥소-2-(몰포리노-1-일)]에틸, [2-옥소-2-(4-메틸 피페라디노-1-일)]에틸 또는 [2-옥소-2-(피페리디노-1-일)]에틸인 청구의 범위 제2항 기재의 벤조티아디아제핀 유도체 및 그 약학적으로 허용되는 염.
- 청구범위 제1항 기재의 벤조티아디아제핀 유도체 또는 그 약학적으로 허용되는 염의 유효량과 약학적으로 허용되는 담체 또는 부형제를 함유하는 항 부정맥제.
- 청구 범위 제4항 기재의 항 부정맥제를 환자에 투여하는 것을 특징으로 하는 항 부정맥 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP63264702A JPH02111766A (ja) | 1988-10-20 | 1988-10-20 | ベンゾチアジアゼピン誘導体及びその塩 |
JP63-264702 | 1988-10-20 | ||
PCT/JP1989/001069 WO1990004590A1 (en) | 1988-10-20 | 1989-10-18 | Benzothiadiazepine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900701770A true KR900701770A (ko) | 1990-12-04 |
Family
ID=17406997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900701322A KR900701770A (ko) | 1988-10-20 | 1989-10-18 | 벤조 티아디아제핀 유도체 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5036065A (ko) |
EP (1) | EP0394484B1 (ko) |
JP (1) | JPH02111766A (ko) |
KR (1) | KR900701770A (ko) |
AT (1) | ATE118488T1 (ko) |
AU (1) | AU615589B2 (ko) |
DE (1) | DE68921198T2 (ko) |
WO (1) | WO1990004590A1 (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0918771A4 (en) | 1996-07-15 | 2001-02-07 | Bristol Myers Squibb Co | THIADIOXOBENZODIAZEPINES FOR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
EP1889198B1 (en) | 2005-04-28 | 2014-11-26 | Proteus Digital Health, Inc. | Pharma-informatics system |
WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
EP2427178B1 (en) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3453266A (en) * | 1966-03-14 | 1969-07-01 | American Home Prod | 1,2,5-benzothiadiazepine 1,1-dioxides |
JPS4643790B1 (ko) * | 1969-01-23 | 1971-12-25 | ||
IT1225729B (it) * | 1988-08-12 | 1990-11-26 | Menarini S A S Firenze A | Derivati della 5,5-diossido-6,11-diidrodibenzo (c,f)(1,2,5) tiadiazepina, loro sali e relativi procedimenti di fabbricazione |
-
1988
- 1988-10-20 JP JP63264702A patent/JPH02111766A/ja active Pending
-
1989
- 1989-10-18 DE DE68921198T patent/DE68921198T2/de not_active Expired - Fee Related
- 1989-10-18 AT AT89911600T patent/ATE118488T1/de active
- 1989-10-18 EP EP89911600A patent/EP0394484B1/en not_active Expired - Lifetime
- 1989-10-18 KR KR1019900701322A patent/KR900701770A/ko not_active IP Right Cessation
- 1989-10-18 AU AU44110/89A patent/AU615589B2/en not_active Ceased
- 1989-10-18 US US07/499,436 patent/US5036065A/en not_active Expired - Fee Related
- 1989-10-18 WO PCT/JP1989/001069 patent/WO1990004590A1/ja active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
AU615589B2 (en) | 1991-10-03 |
JPH02111766A (ja) | 1990-04-24 |
DE68921198T2 (de) | 1995-09-28 |
DE68921198D1 (de) | 1995-03-23 |
AU4411089A (en) | 1990-05-14 |
US5036065A (en) | 1991-07-30 |
WO1990004590A1 (en) | 1990-05-03 |
ATE118488T1 (de) | 1995-03-15 |
EP0394484A1 (en) | 1990-10-31 |
EP0394484B1 (en) | 1995-02-15 |
EP0394484A4 (en) | 1991-07-17 |
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Legal Events
Date | Code | Title | Description |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
LAPS | Lapse due to unpaid annual fee |