KR900700131A - 유사분열물질에 의한 면역자극 혈액처리를 위한 방법 및 장치 - Google Patents

유사분열물질에 의한 면역자극 혈액처리를 위한 방법 및 장치

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Publication number
KR900700131A
KR900700131A KR1019890702371A KR890702371A KR900700131A KR 900700131 A KR900700131 A KR 900700131A KR 1019890702371 A KR1019890702371 A KR 1019890702371A KR 890702371 A KR890702371 A KR 890702371A KR 900700131 A KR900700131 A KR 900700131A
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KR
South Korea
Prior art keywords
mitotic
blood sample
blood
substance
antibody
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KR1019890702371A
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English (en)
Inventor
스벤 에릭 로트만 울프
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스벤 에릭 로트만 울프
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Application filed by 스벤 에릭 로트만 울프 filed Critical 스벤 에릭 로트만 울프
Publication of KR900700131A publication Critical patent/KR900700131A/ko

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/64—Mould opening, closing or clamping devices
    • B29C45/66—Mould opening, closing or clamping devices mechanical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/64—Mould opening, closing or clamping devices
    • B29C45/66—Mould opening, closing or clamping devices mechanical
    • B29C2045/667—Cam drive for mould closing or clamping

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

유사분열물질에 의한 면역자극 혈액처리를 위한 방법 및 장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 따라서 사용되는 혈액자루 시스템의 첫번째 양태를 도시한 것이다. 제2도는 본 발명에 따라서 사용되는 혈액자루 시스템의 두번째 양태를 도시한 것이다. 제3도는 무처리된 집토끼에 주입된 VX2 악성종양에 종양 크기 발전을 도시한 것이다.

Claims (10)

  1. 특정 개체로부터 취해진 세포-함유 샘플, 특히 세포-함유전혈 샘플을 유사분열물질과 함께 시험관내에서 배양하여 동일한 개체에 재투여하고자 고안된 혈액 제제를 제고하는 면역-자극 제제의 제조방법에 있어서, 시험관내에서 유사분열물질과 함께 배양하기 전에 혈액 샘플로부터 유사분열물질에 대한 항체를 제거하는 단계를 더 포함함을 특징으로 하는 면역 자극 제제의 제조방법.
  2. 제 1항에 있어서, 혈액샘플을 대응 유사분열물질 또는 그의 활성 유도체 또는 유사분열물질의 활성 고정화형태와 접촉시킴으로써 혈액샘플로부터 유사분열물질에 대한 항체를 제거하는 방법.
  3. 제1 또는 2항에 있어서, 유사분열물질이 단세포 및/ 또는 B세포와 같은 부세포상의 MHC Ⅱ에 대해 강력한 특이성을 갖는 방법.
  4. 제1 내지 3항중 어느 한 항에 있어서, 유사분열 물질이 SEA, SEB 및 이들의 단편, 특히 유사분열 활성을 가지며 인체에 대해 실질적으로 무독한 단편으로 이루어진 군으로부터 선택되는 방법.
  5. 제4항에 있어서, 유사분열물질이 유사분열활성을 가지면서 인체에 실질적으로 무독하고, 재투여하려고하는 혈액 제제에 이 유사 분열물질이 함유되어 있는 방법.
  6. 제1 내지 5항중 어느 한 항에 있어서, 혈액 샘플의 시험관 내에서의 배양이 생체내에서의 종량 퇴치물질의 후속 생성을 위한 혈액세포의 시험관애 준비를 포함하는 방법.
  7. 유사분열 물질-함유 혈액 샘플을 유사분열물질에 대해 특이성을 갖는 항체와 접촉시켜 유사분열물질을 항체에 결합시키고, 혈액 샘플로부터 항체와 함께 결합 유사분열물질을 분리함을 특징으로 하는, 유사분열물질과 함께 배양된 세포-함유 혈액 샘플로부터 유사분열물질의 분리방법.
  8. 제5항에 있어서, 항체를 혈액 샘플보다 실질적으로 더큰 입경을 갖는 담체에 고정화시키는 방법.
  9. 혈액 샘플 주입구 및 혈액 샘플 배출구를 갖는 적어도 1개의 혈액용기, 혈액 샘플로부터 유사분열물질을 제거하여 배출구에 남아 있는 처리 혈액 샘플이 실질적으로 유사분열활성을 결여하도록 할수 있는 배출구에 설치된 분리장치 및 적어도 1개의 상기 혈액용기에서 유사분열활성을 갖는 적어도 1종의 약품과 혈액샘플을 접촉시키기 위한 장치를 포함함을 특징으로 하는 제1 내지 8항중 어느 한 항에 따른 방법을 수행하기 위한 혈액처리 용구.
  10. 제1 내지 6항중 어느 한 항에 있어서, 혈액샘플이 취해진 개체에 혈액제제를 재투여하는 단계를 더 포함하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890702371A 1988-04-15 1989-04-14 유사분열물질에 의한 면역자극 혈액처리를 위한 방법 및 장치 KR900700131A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE8801426-1 1988-04-15
SE8801426A SE8801426D0 (sv) 1988-04-15 1988-04-15 Forfarande och medel for blodbehandling
PCT/SE1989/000208 WO1989009619A1 (en) 1988-04-15 1989-04-14 Method and means for immuno-stimulating blood treatment with mitogen

Publications (1)

Publication Number Publication Date
KR900700131A true KR900700131A (ko) 1990-08-11

Family

ID=20372041

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890702371A KR900700131A (ko) 1988-04-15 1989-04-14 유사분열물질에 의한 면역자극 혈액처리를 위한 방법 및 장치

Country Status (6)

Country Link
EP (1) EP0406317A1 (ko)
JP (1) JPH03503640A (ko)
KR (1) KR900700131A (ko)
AU (1) AU632999B2 (ko)
SE (1) SE8801426D0 (ko)
WO (1) WO1989009619A1 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6042837A (en) * 1989-09-20 2000-03-28 Kalland; Terje Methods of staphylococcal enterotoxin directed cell-mediated cytotoxicity (SDCC)
SE8903100D0 (sv) * 1989-09-20 1989-09-20 Pharmacia Ab New pharmaceutical agent
US5728388A (en) * 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
CA2078003C (en) * 1990-01-17 2006-11-21 David S. Terman Tumor killing effects of enterotoxins and related compounds
CA2157379A1 (en) * 1993-03-02 1994-09-15 David S. Terman Method of cancer treatment
PT789588E (pt) * 1994-11-17 2005-05-31 Univ South Florida Processo para a producao de um medicamento para o tratamento de imunodeficiencia secundaria
US6977072B2 (en) 2000-10-27 2005-12-20 Irx Therapeutics, Inc. Vaccine immunotherapy for immune suppressed patients
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
DK2234642T3 (en) 2007-11-28 2018-01-08 Irx Therapeutics Inc PROCEDURE FOR INCREASING AN IMMUNOLOGICAL EFFECT
JP5797190B2 (ja) 2009-05-15 2015-10-21 アイ アール エックス セーラピューティクス， インコーポレイテッド ワクチン免疫療法
CN103097543A (zh) 2009-12-08 2013-05-08 伊尔克斯治疗有限公司 逆转朗格汉斯细胞免疫抑制的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU570911B2 (en) * 1981-11-06 1988-03-31 Baylor College Of Medicine Immunoadsorbent based on immobilized protein a and its use
CA1204667A (en) * 1982-10-04 1986-05-20 Masashi Kodama Blood treating material
JPS60501558A (ja) * 1983-06-13 1985-09-19 マリエッテ、コンサルタンツ、リミテッド インタ−フエロン感受性疾病の治療方法およびγ−インタ−フエロン含有製剤の製造方法および装置
US4551435A (en) * 1983-08-24 1985-11-05 Immunicon, Inc. Selective removal of immunospecifically recognizable substances from solution
EP0147689B1 (en) * 1983-12-05 1990-09-19 Asahi Kasei Kogyo Kabushiki Kaisha A method of inducing antitumor immunocytes, and a process for producing antitumor immunocytes and antitumor immunocytes produced by the process
DE68909254T2 (de) * 1988-01-25 1994-04-28 American Cyanamid Co Heparinbindende Gehirnmitogene.
WO1989007448A1 (en) * 1988-02-12 1989-08-24 Regents Of The University Of California Use of synthetic peptides to generate and manipulate cellular immunity

Also Published As

Publication number Publication date
EP0406317A1 (en) 1991-01-09
JPH03503640A (ja) 1991-08-15
WO1989009619A1 (en) 1989-10-19
SE8801426D0 (sv) 1988-04-15
AU632999B2 (en) 1993-01-21
AU3420689A (en) 1989-11-03

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