KR900018026A - 고융점의 다형체 형 테르페나딘의 제조 방법 - Google Patents

고융점의 다형체 형 테르페나딘의 제조 방법 Download PDF

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Publication number
KR900018026A
KR900018026A KR1019900006077A KR900006077A KR900018026A KR 900018026 A KR900018026 A KR 900018026A KR 1019900006077 A KR1019900006077 A KR 1019900006077A KR 900006077 A KR900006077 A KR 900006077A KR 900018026 A KR900018026 A KR 900018026A
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KR
South Korea
Prior art keywords
terpenadine
melting point
high melting
producing polymorphic
polymorphic
Prior art date
Application number
KR1019900006077A
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English (en)
Inventor
조셉 맥카티 프레드릭
Original Assignee
게리 디. 스트리트
메렐 다우 파마슈티칼스 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 게리 디. 스트리트, 메렐 다우 파마슈티칼스 인크. filed Critical 게리 디. 스트리트
Publication of KR900018026A publication Critical patent/KR900018026A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

공융점의 다형체 형 테르페나딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. (a)테프레나딘을 아세톤중에 용해시킴으로써 용액을 형성하고, (b)용액을 물로 희석하고, (c)결정화된 생성물을 모으는 것을 되어 있는 고융점의 다형체 형 테르페나딘의 제조방법.
  2. 제1항에 있어서, 물 대 용액의 부피비가 0.25:1 내지 1:1인 것을 특징으로 하는 방법.
  3. 제1항에 있어서, 테프페나딘 대 아세톤의 중대 대 부피의 비가 80㎎/ℓ내지 200㎎/ℓ인 것을 특징으로 하는 방법.
  4. 제2항에 있어서, 테프페나딘 대 아세톤의 중량 대 부피의 비가 80㎎/ℓ내지 200㎎/ℓ인 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019900006077A 1989-05-01 1990-04-30 고융점의 다형체 형 테르페나딘의 제조 방법 KR900018026A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34579989A 1989-05-01 1989-05-01
US345.799 1989-05-01

Publications (1)

Publication Number Publication Date
KR900018026A true KR900018026A (ko) 1990-12-20

Family

ID=23356531

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900006077A KR900018026A (ko) 1989-05-01 1990-04-30 고융점의 다형체 형 테르페나딘의 제조 방법

Country Status (8)

Country Link
EP (1) EP0396100A1 (ko)
JP (1) JPH02306961A (ko)
KR (1) KR900018026A (ko)
CA (1) CA2015390A1 (ko)
HU (1) HUT54646A (ko)
IE (1) IE901564L (ko)
IL (1) IL94226A0 (ko)
ZA (1) ZA903145B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247092A (en) * 1989-12-29 1993-09-21 Erregierre Industria Chimica S.P.A. Preparation of the high-melting polymorph of terfenadine
FR2681861B1 (fr) * 1991-10-01 1995-06-09 Isochem Sa Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu.
US5347006A (en) * 1992-12-31 1994-09-13 Augusto Lavacchielli Method of preparing a polymorph of terfenadine
IT1270829B (it) * 1993-09-17 1997-05-13 Recordati Chem Pharm Procedimento per la preparazione di polimorfo i della terfenadina con distribuzione granulometrica ottimale

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US4742175A (en) * 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine
IT1217837B (it) * 1988-06-17 1990-03-30 Lepetit Spa Procedimento per la preparazione del "alfa /4(1,1 dimetiletil)fenil/piperidinbutanolo"

Also Published As

Publication number Publication date
IL94226A0 (en) 1991-01-31
JPH02306961A (ja) 1990-12-20
HUT54646A (en) 1991-03-28
ZA903145B (en) 1991-02-27
EP0396100A1 (en) 1990-11-07
CA2015390A1 (en) 1990-11-01
HU902618D0 (en) 1990-09-28
IE901564L (en) 1990-11-01

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