KR900015726A - 이뇨제, 소염제 및 뇌혈제관제로서의 7-치환 아미노-8-치환 카르보닐-메틸아미노-1-옥사스피로[4,5]데칸 - Google Patents
이뇨제, 소염제 및 뇌혈제관제로서의 7-치환 아미노-8-치환 카르보닐-메틸아미노-1-옥사스피로[4,5]데칸 Download PDFInfo
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- KR900015726A KR900015726A KR1019900005561A KR900005561A KR900015726A KR 900015726 A KR900015726 A KR 900015726A KR 1019900005561 A KR1019900005561 A KR 1019900005561A KR 900005561 A KR900005561 A KR 900005561A KR 900015726 A KR900015726 A KR 900015726A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 다음 일반식 (I)의 화합물 및 그의 제약상 허용되는 염의 유효 치료량을 뇌혈관 장해의 치료를 요하는 환자에게 단위 투여 형태로 투여하는 것으로 되어 있는 뇌혈관 장해의 치료 방법.상기 식에서, n은 1 내지 6의 정수이고, X 또는 Y 중 어느 하나는 산소이고, 나머지 하나는 -CH2-이며, R1은 a)(상기 식 중, R4및 R5는 독립적으로 불소, 염소, 브롬, 니트로, 트리플루오로메틸, 탄소 원자수 1 내지 6개의 알킬, 탄소 원자수 1 내지 6개의 알콕시, 또는 아릴임), b) 3,4,5-트리메틸페녹시,(상기 식 중, R6은 수소, 불소, 염소, 탄소 원자수 1 내지 6개의 알킬, 또는 아릴이고, Z는 -CH2-, -O-, -S-, 또는 -NR7(여기서 R7은 수소, 탄소 원자수 1 내지 6개의 알카노일, 또는 탄소 원자수 1 내지 6개의 알킬임)임),(상기 식 중, R8및 R9은 독립적을 수소, 불소, 브롬, 탄소 원자수 1 내지 6개의 알킬, 또는 탄소 원자수 1 내지 4개의 알콕시임), 또는 e)(상기 식 중, R8및 R9는 상기 정의한 바와 같음) 중에서 선택되고, R2는 메틸이고, R3은 수소, 탄소 원자수 1 내지 6개의 알킬,(여기서, R10은 탄소 원자수 1 내지 4개의 알킬임)이거나, 또는 R2및 R3는 부착되어 있는 질소 원자와 함께 할 경우, 이 기들은 피롤리디닐, 피페리디닐 또는 헥사히드로-1H-아제피닐 고리를 형성한다.
- 제1항에 있어서, 뇌혈관 장해가 뇌졸중인 것을 특징으로 하는 치료방법.
- 제1항에 있어서, 상기 화합물이 (-)-5α-7α-8β-N-메틸-N-[7-(1-피롤리디닐)-1-옥사스피로[4.5]데크-8-일]-4-벤조푸란아세트아미드인 것을 특징으로 하는 치료방법.
- 제1항에 있어서, 상기 화합물 또는 제약상 허용되는 염을 0.001mg 내지 10 mg/kg(체중)/1일으로 투여하는 것을 특징으로 하는 치료 방법.
- 제1항의 화합물의 뇌혈관 장해치료의 유효량과 제약상 허용되는 담체의 조합으로 되어 있는 제약 조성물.
- 다음 일반식 (I)의 화합물 및 그의 제약상 허용되는 염의 유효 치료량을 뇌혈관 장해의 치료를 요하는 환자에게 단위 투여 형태로 투여하는 것으로 되어 있는 감염치료 방법.상기 식에서, n은 1 내지 6의 정수이고, X 또는 Y 중 어느 하나는 산소이고, 나머지 하나는 -CH2-이며, R1은 a)(상기 식 중, R4및 R5는 독립적으로 불소, 염소, 브롬, 니트로, 트리플루오로메틸, 탄소 원자수 1 내지 6개의 알킬, 탄소 원자수 1 내지 6개의 알콕시, 또는 아릴임), b) 3,4,5-트리메틸페녹시, c)(상기 식 중, R6은 수소, 불소, 염소, 탄소 원자수 1 내지 6개의 알킬, 또는 아릴이고, Z는 -CH2-, -O-, -S-, 또는 -NR7(여기서 R7은 수소, 탄소 원자수 1 내지 6개의 알카노일, 또는 탄소 원자수 1 내지 6개의 알킬임)임),(상기 식 중, R8및 R9은 독립적을 수소, 불소, 브롬, 탄소 원자수 1 내지 6개의 알킬, 또는 탄소 원자수 1 내지 4개의 알콕시임), 또는 e)(상기 식 중, R8및 R9는 상기 정의한 바와 같음) 중에서 선택되고, R2는 메틸이고, R3은 수소, 탄소 원자수 1 내지 6개의 알킬,(여기서, R10은 탄소 원자수 1 내지 4개의 알킬임)이거나, 또는 R2및 R3는 부착되어 있는 질소 원자와 함께 할 경우, 이 기들은 피롤리디닐, 피페리디닐 또는 헥사히드로-1H-아제피닐 고리를 형성한다.
- 제6항에 있어서, 상기 화합물이 (-)-5α-7α-8β-N-메틸-N-[7-(1-피롤리디닐)-1-옥사스피로[4.5]데크-8-일]-4-벤조[b]푸란아세트아미드인 것을 특징으로 하는 치료방법.
- 제6항에 있어서, 상기 화합물 또는 제약상 허용되는 염을 0.001mg 내지 1 mg/kg(체중)/1일으로 투여하는 것을 특징으로 하는 치료 방법.
- 제6항의 화합물의 염증 치료 유효향과 제약상 허용되는 담체의 조합으로 되어 있는 제약 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019980015878A KR0150182B1 (ko) | 1989-04-21 | 1998-05-02 | 소염제로서의 7-치환 아미노-8-치환 카르보닐-메틸 아미노-1-옥사스피로(4,5)데칸 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US341336 | 1989-04-21 | ||
US07/341,336 US4965278A (en) | 1989-04-21 | 1989-04-21 | 7-(substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro[4,5]decanes as diuretics antiiflammatory, and cerebrovascular agents |
US341,336 | 1989-04-21 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019980015878A Division KR0150182B1 (ko) | 1989-04-21 | 1998-05-02 | 소염제로서의 7-치환 아미노-8-치환 카르보닐-메틸 아미노-1-옥사스피로(4,5)데칸 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900015726A true KR900015726A (ko) | 1990-11-10 |
KR0149491B1 KR0149491B1 (ko) | 1998-10-15 |
Family
ID=23337122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900005561A KR0149491B1 (ko) | 1989-04-21 | 1990-04-20 | 뇌혈관 장해치료제로서의 7-치환 아미노-8-치환카르보닐-메틸아미노-1-옥사스피로(4,5)데칸 |
Country Status (10)
Country | Link |
---|---|
US (1) | US4965278A (ko) |
EP (1) | EP0393696A3 (ko) |
JP (1) | JP3070930B2 (ko) |
KR (1) | KR0149491B1 (ko) |
AU (1) | AU622312B2 (ko) |
CA (1) | CA2014957A1 (ko) |
IE (1) | IE64852B1 (ko) |
NZ (1) | NZ233376A (ko) |
PT (1) | PT93806B (ko) |
ZA (1) | ZA903016B (ko) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5317028A (en) * | 1992-09-08 | 1994-05-31 | Warner-Lambert Co. | 7-((substituted)amino)-8((substituted)carbonyl)-methylamino-1-oxaspiro(4,5)decanes useful in Parkinson's disease, dystonia, and other movement disorders |
US5369120A (en) * | 1993-07-28 | 1994-11-29 | Warner-Lambert Company | Pharmaceutical composition of 7-((substituted)amino-8-((substituted)carbonyl)-(methylamino)-1-oxasp iro(4,5)decanes and L-dopa |
US5489607A (en) * | 1995-02-16 | 1996-02-06 | Warner-Lambert Company | Use of enadoline in the treatment of benign prostatic enlargement |
US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US20020188268A1 (en) | 1999-06-30 | 2002-12-12 | Mark James Kline | Elastomeric side panel for use with convertible absorbent articles |
US5859043A (en) * | 1996-06-11 | 1999-01-12 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method for maintaining kidney function during surgery or severe trauma under general anesthesia |
US6468971B1 (en) | 1997-03-05 | 2002-10-22 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Maintaining kidney function during surgery or trauma |
BR9810706A (pt) * | 1997-07-14 | 2000-08-08 | Adolor Corp | Processo para a prevenção ou tratamento do prurido em um mamìfero em necessidade de tal prevenção ou tratamento |
US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
GB0123571D0 (en) * | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
US7964800B2 (en) * | 2006-05-25 | 2011-06-21 | Fujikura Ltd. | Printed wiring board, method for forming the printed wiring board, and board interconnection structure |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT376669B (de) | 1982-11-26 | 1984-12-27 | Laevosan Gmbh & Co Kg | Verfahren zur herstellung neuer thienylessigsaeureamid-derivate und pharmazeutisch vertraeglicher saeureadditionssalze davon |
US4598087A (en) | 1983-12-06 | 1986-07-01 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
US4618621A (en) * | 1984-09-21 | 1986-10-21 | The Upjohn Company | Method for treating medical conditions involving cerebral ischemia |
US4737493A (en) * | 1985-07-01 | 1988-04-12 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents |
US4663343A (en) | 1985-07-19 | 1987-05-05 | Warner-Lambert Company | Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds |
GB8618188D0 (en) | 1986-07-25 | 1986-09-03 | Ici Plc | Diamine compounds |
EP0258095B1 (fr) | 1986-08-12 | 1991-06-12 | Roussel-Uclaf | Nouveaux dérivés de la décahydroquinoléine, leur procédé de préparation et les nouveaux intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant |
DE3781627T2 (de) | 1986-08-21 | 1993-05-06 | Roussel Uclaf | Indanderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, diese enthaltende pharmazeutische zusammensetzungen und erhaltene zwischenprodukte. |
DE3767816D1 (de) | 1986-09-02 | 1991-03-07 | Zambeletti Spa L | 1-acylsubstituierte piperidinderivate. |
US4876269A (en) | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
EP0261842B1 (en) | 1986-09-17 | 1990-11-22 | Dr. Lo. Zambeletti S.p.A. | N1-acylated-(1-(phenyl or benzyl))-1,2-ethylene diamines |
US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
-
1989
- 1989-04-21 US US07/341,336 patent/US4965278A/en not_active Expired - Lifetime
-
1990
- 1990-04-19 PT PT93806A patent/PT93806B/pt not_active IP Right Cessation
- 1990-04-19 AU AU53686/90A patent/AU622312B2/en not_active Ceased
- 1990-04-19 CA CA002014957A patent/CA2014957A1/en not_active Withdrawn
- 1990-04-19 NZ NZ233376A patent/NZ233376A/xx unknown
- 1990-04-20 ZA ZA903016A patent/ZA903016B/xx unknown
- 1990-04-20 EP EP19900107514 patent/EP0393696A3/en not_active Withdrawn
- 1990-04-20 KR KR1019900005561A patent/KR0149491B1/ko not_active IP Right Cessation
- 1990-04-20 IE IE142290A patent/IE64852B1/xx not_active IP Right Cessation
- 1990-04-20 JP JP2103207A patent/JP3070930B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IE901422L (en) | 1990-10-21 |
ZA903016B (en) | 1991-12-24 |
KR0149491B1 (ko) | 1998-10-15 |
PT93806A (pt) | 1990-11-20 |
JP3070930B2 (ja) | 2000-07-31 |
EP0393696A2 (en) | 1990-10-24 |
US4965278A (en) | 1990-10-23 |
CA2014957A1 (en) | 1990-10-21 |
NZ233376A (en) | 1999-08-30 |
PT93806B (pt) | 1996-09-30 |
IE64852B1 (en) | 1995-09-06 |
JPH02292218A (ja) | 1990-12-03 |
EP0393696A3 (en) | 1992-09-02 |
AU5368690A (en) | 1990-10-25 |
AU622312B2 (en) | 1992-04-02 |
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