KR900004352A - 뇌졸중 치료용 의약 - Google Patents
뇌졸중 치료용 의약 Download PDFInfo
- Publication number
- KR900004352A KR900004352A KR1019890013434A KR890013434A KR900004352A KR 900004352 A KR900004352 A KR 900004352A KR 1019890013434 A KR1019890013434 A KR 1019890013434A KR 890013434 A KR890013434 A KR 890013434A KR 900004352 A KR900004352 A KR 900004352A
- Authority
- KR
- South Korea
- Prior art keywords
- active compound
- use according
- nmol
- stroke
- binding
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 3
- 229940079593 drug Drugs 0.000 title 1
- 238000002483 medication Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 15
- 208000006011 Stroke Diseases 0.000 claims 2
- 239000003420 antiserotonin agent Substances 0.000 claims 2
- JRZGPXSSNPTNMA-UHFFFAOYSA-N 1,2,3,4-tetrahydronaphthalen-1-amine Chemical class C1=CC=C2C(N)CCCC2=C1 JRZGPXSSNPTNMA-UHFFFAOYSA-N 0.000 claims 1
- IHWDSEPNZDYMNF-UHFFFAOYSA-N 1H-indol-2-amine Chemical class C1=CC=C2NC(N)=CC2=C1 IHWDSEPNZDYMNF-UHFFFAOYSA-N 0.000 claims 1
- DPTWORPMSGTYRE-UHFFFAOYSA-N 2,3,3a,4-tetrahydrobenzo[g]indol-1-amine Chemical class C1=CC=CC2=C3N(N)CCC3CC=C21 DPTWORPMSGTYRE-UHFFFAOYSA-N 0.000 claims 1
- ZGBMWKMFXGAPJO-UHFFFAOYSA-N 2h-thiopyran-2-amine Chemical class NC1SC=CC=C1 ZGBMWKMFXGAPJO-UHFFFAOYSA-N 0.000 claims 1
- 125000004853 tetrahydropyridinyl group Chemical class N1(CCCC=C1)* 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Instructional Devices (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Peptides Or Proteins (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (13)
- 세로토닌 길항제로 작용하며 5HT1A수용체에 결합시의 결합 강도가 10,000nmol/1 미만인 유효 화합물의 뇌졸증 치료용 의약의 제조 용도.
- 제1항에 있어서, 유효 화합물의 결합 강도가 1,000nmol/1 미만임을 특징으로 하는 화합물의 용도.
- 제1항 또는 제2항에 있어서, 유효 화합물의 결합 강도가 0.1 내지 100nmol/1임을 특징으로 하는 화합물의 용도.
- 제1항 내지 제3항 중 어느 하나의 항에 있어서, 유효화합물을 아릴-및 헤타릴-피페라진류로부터 선택하여 사용함을 특징으로 하는 용도.
- 제1항 내지 제3항 중 어느 하나의 항에 있어서, 유효화합물을 아미노테트라히드로벤즈인돌류로부터 선택하여 사용함을 특징으로 하는 용도.
- 제1항 내지 제3항 중 어느 하나의 항에 있어서, 유효화합물을 인돌라민류로부터 선택하여 사용함을 특징으로 하는 용도.
- 제1항 내지 제3항 중 어느 하나의 항에 있어서, 유효화합물을 아미노알킬-벤조디옥산류로부터 선택하여 사용함을 특징으로 하는 용도.
- 제1항 내지 제3항 중 어느 하나의 항에 있어서, 유효화합물을 아미노테트랄린류로부터 선택하여 사용함을 특징으로 하는 용도.
- 제1항 내지 제3항 중 어느 하나의 항에 있어서, 유효화합물을 아미노크로만류 및 아미노티오피란류로부터 선택하여 사용함을 특징으로 하는 용도.
- 제1항 내지 제3항 중 어느 하나의 항에 있어서, 유효화합물을 인돌릴-알킬피페리딘류로부터 선택하여 사용함을 특징으로 하는 용도.
- 제1항 내지 제3항 중 어느 하나의 항에 있어서, 유효화합물을 테트라히드로피리딘류로부터 선택하여 사용함을 특징으로 하는 용도.
- 세로토닌 길항제로서 작용하고 5HT1A수용체에 결합시의 결합 강도가 10,000nmol/1 미만인 유효 화합물을 함유한 뇌졸중 치료용 의약.
- 제12항에 있어서, 유효 화합물을 0.01 내지 20중량% 함유한 의약.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019970061359A KR0149275B1 (en) | 1988-09-20 | 1997-11-20 | Medicaments for the treatment of cerebral apoplexy |
KR1019970061361A KR0149274B1 (en) | 1988-09-20 | 1997-11-20 | Medicaments for the treatment of cerebral apoplexy |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3831888A DE3831888A1 (de) | 1988-09-20 | 1988-09-20 | Arzneimittel zur behandlung von apoplexia cerebri |
DEP3831888.1 | 1988-09-20 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019970061360A Division KR0146486B1 (ko) | 1988-09-20 | 1997-11-20 | 뇌졸증 치료용 의약 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900004352A true KR900004352A (ko) | 1990-04-12 |
KR0135307B1 KR0135307B1 (ko) | 1998-04-23 |
Family
ID=6363313
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890013434A KR0135307B1 (ko) | 1988-09-20 | 1989-09-19 | 뇌졸중 치료용 의약 |
KR1019970061360A KR0146486B1 (ko) | 1988-09-20 | 1997-11-20 | 뇌졸증 치료용 의약 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019970061360A KR0146486B1 (ko) | 1988-09-20 | 1997-11-20 | 뇌졸증 치료용 의약 |
Country Status (15)
Country | Link |
---|---|
US (3) | US4988700A (ko) |
EP (1) | EP0360077B1 (ko) |
JP (1) | JP2669507B2 (ko) |
KR (2) | KR0135307B1 (ko) |
AT (1) | ATE91623T1 (ko) |
AU (1) | AU619895B2 (ko) |
CA (1) | CA1331139C (ko) |
DE (2) | DE3831888A1 (ko) |
DK (1) | DK175128B1 (ko) |
ES (1) | ES2058426T3 (ko) |
FI (1) | FI894404A (ko) |
HU (1) | HU203475B (ko) |
IE (1) | IE62697B1 (ko) |
IL (1) | IL91660A (ko) |
PH (1) | PH26920A (ko) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2097607A1 (en) * | 1990-12-24 | 1992-06-24 | Marcel Hibert | Use of certain glutarimide derivatives in the treatment of depression and mania |
DE4135473A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | Triazaspirodecanon-methylchromane |
DE4138756A1 (de) * | 1991-11-26 | 1993-05-27 | Troponwerke Gmbh & Co Kg | Kombination mit neuroprotektiver wirkung |
ES2085247T1 (es) * | 1992-09-25 | 1996-06-01 | Synaptic Pharma Corp | Receptores adrenergicos alfa 1 humanos que codifican dna y sus utilizaciones. |
AU5446894A (en) * | 1992-10-23 | 1994-05-24 | New York University | Functional interactions between glial s-100b and central nervous system serotonergic neurons |
ATE255888T1 (de) | 1998-06-01 | 2003-12-15 | Ortho Mcneil Pharm Inc | Tetrahydronaphtalene verbindungen und deren verwendung zur behandlung von neurodegenerativen krankheiten |
EP1087963B1 (en) | 1998-06-19 | 2004-08-25 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
WO2000004012A1 (en) | 1998-07-17 | 2000-01-27 | Synaptic Pharmaceutical Corporation | COMPOUNDS SPECIFIC FOR THE HUMAN α1d ADRENERGIC RECEPTOR AND USES THEREOF |
US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
DE19900544A1 (de) * | 1999-01-11 | 2000-07-13 | Basf Ag | Verwendung von Verbindungen der Formel I zur Prophylaxe und Therapie der zerebralen Ischämie |
US20040106623A1 (en) * | 1999-07-16 | 2004-06-03 | Synaptic Pharmaceutical Corporation | Compounds specific for the human alpha1d adrenergic receptor and uses thereof |
US7053092B2 (en) | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US20040002500A1 (en) * | 2002-06-28 | 2004-01-01 | Fabre Kramer Pharmaceutical, Inc. | Methods for treating attention deficit disorder |
US20040077996A1 (en) * | 2002-10-22 | 2004-04-22 | Jasperson Keith E. | Drug infusion system with multiple medications |
BRPI0607517A2 (pt) | 2005-04-13 | 2009-09-08 | Neuraxon Inc | compostos de indol substituìdo, composição farmacêutica compreendendo o mesmo, método para tratar e uso do mesmo |
WO2007118314A1 (en) * | 2006-04-13 | 2007-10-25 | Neuraxon, Inc. | 1,5 and 3,6- substituted indole compounds having nos inhibitory activity |
AU2008323526A1 (en) * | 2007-11-16 | 2009-05-22 | Neuraxon, Inc. | Indole compounds and methods for treating visceral pain |
US20090131503A1 (en) * | 2007-11-16 | 2009-05-21 | Annedi Subhash C | 3,5 - substituted indole compounds having nos and norepinephrine reuptake inhibitory activity |
EP2219449A4 (en) * | 2007-11-16 | 2010-10-27 | Univ Arizona State | METHOD FOR THE TREATMENT OF EXPOSURE TO DAMAGING |
KR102357405B1 (ko) | 2021-05-07 | 2022-02-09 | 정진구 | 호흡기 운동기구 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8810748D0 (en) * | 1988-05-06 | 1988-06-08 | Beecham Wuelfing Gmbh & Co Kg | Novel treatment |
-
1988
- 1988-09-20 DE DE3831888A patent/DE3831888A1/de not_active Withdrawn
-
1989
- 1989-09-06 PH PH39203A patent/PH26920A/en unknown
- 1989-09-07 ES ES89116496T patent/ES2058426T3/es not_active Expired - Lifetime
- 1989-09-07 EP EP89116496A patent/EP0360077B1/de not_active Expired - Lifetime
- 1989-09-07 AT AT89116496T patent/ATE91623T1/de not_active IP Right Cessation
- 1989-09-07 DE DE8989116496T patent/DE58904960D1/de not_active Expired - Fee Related
- 1989-09-14 US US07/407,161 patent/US4988700A/en not_active Expired - Lifetime
- 1989-09-15 IL IL91660A patent/IL91660A/xx not_active IP Right Cessation
- 1989-09-15 AU AU41456/89A patent/AU619895B2/en not_active Ceased
- 1989-09-18 CA CA000611736A patent/CA1331139C/en not_active Expired - Fee Related
- 1989-09-18 FI FI894404A patent/FI894404A/fi not_active Application Discontinuation
- 1989-09-19 DK DK198904616A patent/DK175128B1/da not_active IP Right Cessation
- 1989-09-19 KR KR1019890013434A patent/KR0135307B1/ko not_active IP Right Cessation
- 1989-09-19 IE IE299089A patent/IE62697B1/en not_active IP Right Cessation
- 1989-09-20 JP JP1242417A patent/JP2669507B2/ja not_active Expired - Fee Related
- 1989-09-20 HU HU894897A patent/HU203475B/hu not_active IP Right Cessation
-
1990
- 1990-09-10 US US07/579,414 patent/US5070102A/en not_active Expired - Lifetime
-
1991
- 1991-06-13 US US07/714,470 patent/US5155128A/en not_active Expired - Lifetime
-
1997
- 1997-11-20 KR KR1019970061360A patent/KR0146486B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR0146486B1 (ko) | 1998-08-17 |
ES2058426T3 (es) | 1994-11-01 |
DE3831888A1 (de) | 1990-03-29 |
IE62697B1 (en) | 1995-02-22 |
HU203475B (en) | 1991-08-28 |
US5155128A (en) | 1992-10-13 |
EP0360077B1 (de) | 1993-07-21 |
EP0360077A3 (de) | 1992-03-11 |
PH26920A (en) | 1992-12-03 |
CA1331139C (en) | 1994-08-02 |
DK175128B1 (da) | 2004-06-07 |
EP0360077A2 (de) | 1990-03-28 |
IL91660A0 (ko) | 1990-04-29 |
FI894404A0 (fi) | 1989-09-18 |
DE58904960D1 (de) | 1993-08-26 |
US5070102A (en) | 1991-12-03 |
AU619895B2 (en) | 1992-02-06 |
JPH02121935A (ja) | 1990-05-09 |
IL91660A (en) | 1993-08-18 |
DK461689D0 (da) | 1989-09-19 |
HUT52699A (en) | 1990-08-28 |
IE892990L (en) | 1990-03-20 |
AU4145689A (en) | 1990-03-29 |
KR0135307B1 (ko) | 1998-04-23 |
US4988700A (en) | 1991-01-29 |
DK461689A (da) | 1990-03-21 |
JP2669507B2 (ja) | 1997-10-29 |
ATE91623T1 (de) | 1993-08-15 |
FI894404A (fi) | 1990-03-21 |
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