KR890016057A - Method for preparing clindamycin-2-phosphate - Google Patents

Method for preparing clindamycin-2-phosphate Download PDF

Info

Publication number
KR890016057A
KR890016057A KR1019880004319A KR880004319A KR890016057A KR 890016057 A KR890016057 A KR 890016057A KR 1019880004319 A KR1019880004319 A KR 1019880004319A KR 880004319 A KR880004319 A KR 880004319A KR 890016057 A KR890016057 A KR 890016057A
Authority
KR
South Korea
Prior art keywords
acid
formula
compound
reaction
clindamycin
Prior art date
Application number
KR1019880004319A
Other languages
Korean (ko)
Other versions
KR910005418B1 (en
Inventor
조성기
김종환
조준상
이상무
Original Assignee
손영희
제일제당 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 손영희, 제일제당 주식회사 filed Critical 손영희
Priority to KR1019880004319A priority Critical patent/KR910005418B1/en
Publication of KR890016057A publication Critical patent/KR890016057A/en
Application granted granted Critical
Publication of KR910005418B1 publication Critical patent/KR910005418B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음No content

Description

클린다마이신-2-포스페이트의 제조방법Method for preparing clindamycin-2-phosphate

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

구조식(Ⅰ)로 표현되는 3,4-O-아릴리덴-클린다마이신 염산염을 삼차아민류의 염기존재하에 비스(2,2,2-삼염화에틸)-포스포로클로리데이트와 포스포틸화 반응시켜 구조식(Ⅱ)의 화합물을 합성한 다음, 구조식(Ⅱ)의 화합물을 아연가루를 사용하여 산가수분해 반응시킴을 특징으로하는 구조식(Ⅲ)으로 표현되는 클린다마이신-2-포스페이트의 제조방법.3,4-O-arylidene-clindamycin hydrochloride represented by Structural Formula (I) was reacted with bis (2,2,2-ethyl trichloride) -phosphorochloridate in the presence of a base of tertiary amines to form a phosphorylation reaction. A method for producing clindamycin-2-phosphate represented by formula (III), wherein the compound of formula (II) is synthesized, and then the compound of formula (II) is subjected to an acid hydrolysis reaction using zinc powder. 제 1 항에 있어서, 삼차아민류의 염기는 트리에틸아민, 피리딘, 트리프로필아민, 트리부틸아민, 트리이소프로필아민, 디메틸아닐린, N-메틸피페리딘을 사용함을 특징으로하는 방법.The method of claim 1, wherein the bases of the tertiary amines are triethylamine, pyridine, tripropylamine, tributylamine, triisopropylamine, dimethylaniline, N-methylpiperidine. 제 1 항에 있어서, 포스포틸화 반응은 0℃에서 10시간 동안 행함을 특징으로 하는 방법.The method of claim 1 wherein the phosphotylation reaction is conducted at 0 ° C. for 10 hours. 제 1 항에 있어서, 산가수분해 반응시 포름산, 프로피온산, 희석된 염산, 희석된 황산, 80% 초산등을 사용함을 특징으로 하는 방법.The method according to claim 1, wherein formic acid, propionic acid, diluted hydrochloric acid, diluted sulfuric acid, 80% acetic acid, and the like are used in the acid hydrolysis reaction. 다음 구조식으로 표현되는 화합물.A compound represented by the following structural formula. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019880004319A 1988-04-15 1988-04-15 Process for preparing clindamycin-2-phosphate KR910005418B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019880004319A KR910005418B1 (en) 1988-04-15 1988-04-15 Process for preparing clindamycin-2-phosphate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019880004319A KR910005418B1 (en) 1988-04-15 1988-04-15 Process for preparing clindamycin-2-phosphate

Publications (2)

Publication Number Publication Date
KR890016057A true KR890016057A (en) 1989-11-28
KR910005418B1 KR910005418B1 (en) 1991-07-29

Family

ID=19273663

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880004319A KR910005418B1 (en) 1988-04-15 1988-04-15 Process for preparing clindamycin-2-phosphate

Country Status (1)

Country Link
KR (1) KR910005418B1 (en)

Also Published As

Publication number Publication date
KR910005418B1 (en) 1991-07-29

Similar Documents

Publication Publication Date Title
KR870004009A (en) Method for preparing thiazole derivative
KR850008657A (en) Method of producing formic acid
KR840007016A (en) Method for preparing crystalline cefem-acid addition salt
KR830007686A (en) Method for preparing cephalosporin derivative
KR830006906A (en) Method for preparing cychloropropane carboxylate
KR890000420A (en) Method for preparing 3-cyano-4-aryl-pyrrole
KR890016057A (en) Method for preparing clindamycin-2-phosphate
KR870005954A (en) Improved process for preparing 5- (2,5-dimethylphenoxy) -2,2-dimethylpentanoic acid
KR840006197A (en) Method for preparing N-formyl-L-aspartic anhydride
KR860000295A (en) Method for preparing oxycam derivative
KR860004004A (en) Method for preparing 4-acyloxy-3-oxo-butyric acid ester
KR850005413A (en) Method of preparing aminonitropyridine
KR850001744A (en) Preparation of 4-R'-5-Q-1,6-naphthyridine-2 (1H)-warms
KR850006428A (en) Method for preparing erythromycin acetate
KR930002342A (en) Method for preparing quinoline derivative
KR860002473A (en) Method for preparing 4-methyl-5-thioformamidinomethylimidazole dihydrochloride
KR860001066A (en) Method for preparing pyrrolidine derivative
KR860002471A (en) Manufacturing method of pyrazole herbicide
KR870006023A (en) Method for preparing N-sulfamoyl-3- (2-guanidinothiazol-4-ylmethylthio) propionamidine derivative
KR850004566A (en) Process for preparing organic carboxylic acid
KR860004066A (en) Process for preparing piperacilline
KR880000443A (en) Method for producing ampicillin (5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl ester hydrochloride
KR830006322A (en) Method for preparing nicotinic acid derivative of glucosamine
KR880000449A (en) Method for preparing cefem derivatives
KR850008493A (en) Method for preparing N-formyl-dithiophosphonic acid amide

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20010619

Year of fee payment: 11

LAPS Lapse due to unpaid annual fee