KR860004066A - Process for preparing piperacilline - Google Patents

Process for preparing piperacilline Download PDF

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Publication number
KR860004066A
KR860004066A KR1019840007038A KR840007038A KR860004066A KR 860004066 A KR860004066 A KR 860004066A KR 1019840007038 A KR1019840007038 A KR 1019840007038A KR 840007038 A KR840007038 A KR 840007038A KR 860004066 A KR860004066 A KR 860004066A
Authority
KR
South Korea
Prior art keywords
compound
formula
piperacillin
preparing
iii
Prior art date
Application number
KR1019840007038A
Other languages
Korean (ko)
Inventor
김영설
Original Assignee
김영설
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 김영설 filed Critical 김영설
Priority to KR1019840007038A priority Critical patent/KR860004066A/en
Priority to JP60058619A priority patent/JPS61115086A/en
Publication of KR860004066A publication Critical patent/KR860004066A/en
Priority to JP62330180A priority patent/JPS63239282A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/70—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with hetero rings as additional substituents on the carbon chain

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음No content

Description

피페라실린(Piperacilline)의 제조방법Process for preparing piperacilline

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (4)

다음 구조식(Ⅲ) 화합물과 1―하이드록시벤조트리아졸을 비극성용매 중에서 반응시켜 구조식(Ⅳ)화합물을 제조하고, 구조식(Ⅳ) 화합물과 구조식(Ⅱ)화합물을 반응시킴을 특징으로 하는 구조식(Ⅰ)의 피페라실린의 제조방법.A compound of formula (III) is prepared by reacting a compound of formula (III) with 1-hydroxybenzotriazole in a nonpolar solvent and reacting a compound of formula (IV) with a compound of formula (II). Method for preparing piperacillin). 제1항에서, 구조식(Ⅲ) 화합물과 1―하이드록시벤조트리아졸을 톨루엔이나 벤젠 중에서 3―5시간 환류시켜 구조식(Ⅳ) 화합물을 제조함을 특징으로 하는 피페라실린의 제조방법.The method for producing piperacillin according to claim 1, wherein the compound of formula (III) and 1-hydroxybenzotriazole are refluxed in toluene or benzene for 3-5 hours to produce the compound of formula (IV). 제1항에 있어서, 구조식(Ⅳ)화합물과 구조식화합물을 물과 아세톤, 아세토니트릴, 에틸아세테이트의 혼합용매중에서 반응시킴을 특징으로 하는 피페라실린의 제조방법.The method for producing piperacillin according to claim 1, wherein the compound of formula (IV) and the compound of formula are reacted in a mixed solvent of water, acetone, acetonitrile and ethyl acetate. 제1항에 있어서, 구조식(Ⅳ)화합물과 구조식(Ⅱ) 화합물을 33―35℃에서 3―5시간 반응시킴을 특징으로 하는 피페라실린의 제조방법.The method for producing piperacillin according to claim 1, wherein the compound of formula (IV) and the compound of formula (II) are reacted at 33-35 ° C. for 3-5 hours. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840007038A 1984-11-10 1984-11-10 Process for preparing piperacilline KR860004066A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019840007038A KR860004066A (en) 1984-11-10 1984-11-10 Process for preparing piperacilline
JP60058619A JPS61115086A (en) 1984-11-10 1985-03-25 Manufacture of piperacillins
JP62330180A JPS63239282A (en) 1984-11-10 1987-12-28 Novel piperazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840007038A KR860004066A (en) 1984-11-10 1984-11-10 Process for preparing piperacilline

Publications (1)

Publication Number Publication Date
KR860004066A true KR860004066A (en) 1986-06-16

Family

ID=19236137

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840007038A KR860004066A (en) 1984-11-10 1984-11-10 Process for preparing piperacilline

Country Status (2)

Country Link
JP (2) JPS61115086A (en)
KR (1) KR860004066A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3151682A1 (en) * 2014-06-05 2017-04-12 Nestec S.A. Rotary die assemblies, methods for using same, and food products made by same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2440268A1 (en) * 1974-08-22 1976-03-04 Bayer Ag BETA-LACTAMANTIBIOTICS, THE METHOD OF MANUFACTURING AND THEIR USE AS A MEDICINAL PRODUCT
DE2528079A1 (en) * 1975-06-24 1977-01-20 Bayer Ag PENICILLIN, THE METHOD FOR MANUFACTURING IT AND THEIR USE AS A MEDICINAL PRODUCT
JPS52106883A (en) * 1976-02-13 1977-09-07 Toyama Chem Co Ltd Novel penicillins and cephalosporins

Also Published As

Publication number Publication date
JPS61115086A (en) 1986-06-02
JPS63239282A (en) 1988-10-05

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