KR890014119A - 사이클릭 amp 유도체 연고제 - Google Patents

사이클릭 amp 유도체 연고제 Download PDF

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Publication number
KR890014119A
KR890014119A KR1019890004031A KR890004031A KR890014119A KR 890014119 A KR890014119 A KR 890014119A KR 1019890004031 A KR1019890004031 A KR 1019890004031A KR 890004031 A KR890004031 A KR 890004031A KR 890014119 A KR890014119 A KR 890014119A
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KR
South Korea
Prior art keywords
ointment
cyclic phosphate
adenosine
sodium
benzylthio
Prior art date
Application number
KR1019890004031A
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English (en)
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KR970007905B1 (ko
Inventor
사다오 히로타
히토시 야마우치
Original Assignee
스즈끼 타다시
다이이치세이야꾸가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 스즈끼 타다시, 다이이치세이야꾸가부시끼가이샤 filed Critical 스즈끼 타다시
Publication of KR890014119A publication Critical patent/KR890014119A/ko
Application granted granted Critical
Publication of KR970007905B1 publication Critical patent/KR970007905B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

사이클릭 AMP 유도체 연고제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 활성성분인 아데노신 3´,5´- 사이클릭 포스페이트 유도체, 흡수성과 건조특성이 있는 연고 기제, 삭카라이드 및/또는 무기 고중합체를 포함함을 특징으로 하는 연고제.
  2. 제1항에 있어서, 아데노신 3´,5´- 사이클릭 포스페이트 유도체가 나트륨 N6, 2´-0-디부티릴아데노신 3´,5´- 사이클릭 포스페이트, 나트륨 2´-0-부티릴아데노신 3´,5´- 사이클릭 포스페이트, 나트륨 N6-부티릴아데노신 3´,5´- 사이클릭 포스페이트, 나트륨 아데노신 3´,5´- 사이클릭 포스페이트, 8-벤질티오- N6-부티릴아데노신 3´,5´- 사이클릭 포스페이트, 8-벤질티오 2´-0-부티릴아데노신 3´,5´- 사이클릭 포스페이트 또는 8-벤질티오 아데노신 3´,5´- 사이클릭 포스페이트인 연고제.
  3. 제1항에 있어서, 연고 기제가 분자량이 서로 상이한 두가지 이상의 폴리에틸렌 글리콜을 포함함을 특징으로 하는 연고제.
  4. 제1항에 있어서, 삭카라이드가 덱스트린, 덱스트란, α-,β- 또는 γ- 사이클로 덱스트린 또는 이의 혼합물인 연고제.
  5. 제1항에 있어서, 삭카라이드를 연고 기제 100중량부당 약 0.5 내지 20부의 양으로 사용하는 연고제.
  6. 제1항에 있어서, 무기 고중합체가 무수 수산화 알루미늄 겔, 합성 마그네슘 실리케이트, 하이드로탈사이트 또는 이의 혼합물인 연고제.
  7. 제1항에 있어서, 무기 고중합체를 연고 기제 100중량부당 약 0.1내지 10부의 양으로 사용하는 연고제.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019890004031A 1988-03-30 1989-03-30 사이클릭 amp 유도체 연고제 KR970007905B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP63-77915 1988-03-30
JP77915/88 1988-03-30
JP7791588 1988-03-30

Publications (2)

Publication Number Publication Date
KR890014119A true KR890014119A (ko) 1989-10-21
KR970007905B1 KR970007905B1 (ko) 1997-05-17

Family

ID=13647370

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890004031A KR970007905B1 (ko) 1988-03-30 1989-03-30 사이클릭 amp 유도체 연고제

Country Status (6)

Country Link
US (1) US5096891A (ko)
EP (1) EP0335379B1 (ko)
KR (1) KR970007905B1 (ko)
AU (1) AU619532B2 (ko)
CA (1) CA1322957C (ko)
DE (1) DE68901799T2 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2634374B1 (fr) * 1988-07-19 1993-10-15 Laboratoires Serobiologiques Agents photoprotecteurs, cytophotoprotecteurs cutanes ayant une activite photoprotectrice des cellules constitutives, fonctionnelles de la peau, en particulier des cellules de langerhans, a base de composes nucleiques : nucleoprotides, ribonucleotides et desoxyribonucleotides, ribonucleosides et desoxyribonucleosides, compositions cosmetiques ou dermo-pharmaceutiques contenant un tel agent ainsi que des nouveaux composes en soi
FR2649610B1 (fr) * 1989-07-13 1994-06-03 Dior Christian Parfums Composition cosmetique ou pharmaceutique et notamment dermatologique contenant de l'ampc ou ses derives en liposomes
CA2052193A1 (en) * 1990-09-28 1992-03-29 Norio Takasugi Topical powder composition containing cyclic amp derivative
AU657033B2 (en) * 1992-01-27 1995-02-23 Daiichi Pharmaceutical Co., Ltd. Cyclic AMP derivative-containing ointment

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978213A (en) * 1972-07-10 1976-08-31 Nelson Research & Development Company Cosmetic use of cyclic amp and phosphodiesterase inhibitors
US4537767A (en) * 1973-01-29 1985-08-27 Pharmacia Aktiebolag Method for cleansing fluid discharging skin surfaces, wounds and mucous membranes and means for carrying out the method
US4005191A (en) * 1974-06-04 1977-01-25 Clark Mary G Topical ointment composition
FR2358155A1 (fr) * 1976-07-15 1978-02-10 Lapinet Eugene Composition pour le traitement et la prevention de l'irritation et de l'inflammation de la peau, de l'oeil et des muqueuses
US4271144A (en) * 1979-06-06 1981-06-02 Holles Laboratories, Inc. Dextran composition for controlling corneal hydration
DE2947742C2 (de) * 1979-11-27 1986-04-03 Koch, Jürgen, Dr., 2000 Hamburg Arzneimittel, enthaltend β-Cyclodextrin
US4481197A (en) * 1980-04-25 1984-11-06 Burroughs Wellcome Co. Anti-inflammatory deoxyribosides
JPS5838250A (ja) * 1981-09-01 1983-03-05 Teikoku Chem Ind Corp Ltd 複合体
JPS6197229A (ja) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd 安定なエリトロポエチン製剤
US4791103A (en) * 1985-02-08 1988-12-13 Warner-Lambert Company 2,N6 -disubstituted adenosines, derivatives and methods of use
JPH0653658B2 (ja) * 1984-12-17 1994-07-20 中外製薬株式会社 安定な錠剤の製造法
JPS62286925A (ja) * 1986-06-06 1987-12-12 Terumo Corp 水酸化アルミニウムゲルを含有する外用薬組成物
DE3786714T2 (de) * 1986-06-16 1994-03-10 Daiichi Seiyaku Co Therapeutisches Mittel für Hautgeschwüre.
US4793998A (en) * 1986-10-20 1988-12-27 Warner-Lambert Company Stabilized drug compositions

Also Published As

Publication number Publication date
EP0335379B1 (en) 1992-06-17
EP0335379A3 (en) 1990-01-10
CA1322957C (en) 1993-10-12
KR970007905B1 (ko) 1997-05-17
AU619532B2 (en) 1992-01-30
US5096891A (en) 1992-03-17
EP0335379A2 (en) 1989-10-04
DE68901799T2 (de) 1993-02-04
AU3227089A (en) 1989-10-05
DE68901799D1 (de) 1992-07-23

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