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Application filed by 다무라 시로오, 니홍 이야꾸힝 고오교 가부시끼가이샤, 다께다 시게끼, 가부시끼가이샤 산요 가가꾸 겐뀨쇼filedCritical다무라 시로오
Priority to KR870014715ApriorityCriticalpatent/KR890009860A/en
Publication of KR890009860ApublicationCriticalpatent/KR890009860A/en
광학적 활성 카르복실산 유도체 L-리진염 및 그의 제조방법.Optically active carboxylic acid derivative L-lysine salt and method for preparing the same.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.
Claims (8)
하기식(Ⅰ)로 나타내어지는 d-트레오-2-히드록시-3-(2-아미노페닐티오)-3-(4-메톡시페닐)-프로리온산과 L-리진과의 염.A salt of d-threo-2-hydroxy-3- (2-aminophenylthio) -3- (4-methoxyphenyl) -prolic acid represented by the following formula (I) with L-lysine.상기식에서, *C는 광학적으로 분활된 분자의 탄소원자를 나타낸다.In the formula, * C represents a carbon atom of the optically divided molecule.하기식(Ⅱ)로 나타내어지는 d1-트레오-2-히드록시-3-(2-아미노페닐티오)-3-(4-메톡시페놀)-프로피온산을 L-리진과 반응시키거나 상기 프로피온산의 금속염을 L-리진의 산염과 반응시켜 상응하는 염을 생성하고, 생성된 2개의 광학적 활성염으로부터 이들염의 특정 용매중 용해도 차를 이용하여 난용성염을 분리시킴을 특징으로 하여, 하기식(Ⅰ)로 나타내어지는 d-트레오-2-히드록시-3-(2-아미노페닐티오)-3-(4-메톡시페닐)-프로피온산과 L-리진과의 염을 제조하는 방법.D1-threo-2-hydroxy-3- (2-aminophenylthio) -3- (4-methoxyphenol) -propionic acid represented by the following formula (II) is reacted with L-lysine or a metal salt of the propionic acid Is reacted with an acid salt of L-lysine to produce the corresponding salt, and from the resulting two optically active salts, the poorly soluble salts are separated using a difference in solubility in a specific solvent thereof, A process for preparing a salt of d-threo-2-hydroxy-3- (2-aminophenylthio) -3- (4-methoxyphenyl) -propionic acid and L-lysine as shown.상기식에서, *C는 광학적으로 분할된 분자의 탄소원자를 나타낸다.In the formula, * C represents the carbon atom of the optically divided molecule.제2항에 있어서, 언급된 용매가 수성 유기 용매인 방법.The process of claim 2 wherein the solvent mentioned is an aqueous organic solvent.제3항에 있어서, 언급된 수성 용기 용매가 저급알콕과 물과의 혼합물 또는 아세톤과 물과의 혼합물인 방법.4. The process according to claim 3, wherein the aqueous container solvent mentioned is a mixture of lower alkoxy and water or a mixture of acetone and water.제2항에 있어서, 식(Ⅱ)의 d1-트레오-2-히드록시-3-(2-아미노페닐티오)-3-(4-메톡시페닐)-프로피온산 또는 그의 금속염 1당량당 약 1 내지 약 1.2당량의 리진 또는 그의 산염을 사용하는 방법.The compound of claim 2, wherein the compound is represented by about 1 to about 1 equivalent of d 1 -threo-2-hydroxy-3- (2-aminophenylthio) -3- (4-methoxyphenyl) -propionic acid or a metal salt thereof of formula (II). Using about 1.2 equivalents of lysine or its acid salt.제2항에 있어서, d1-트레오-2-히드록시-3-(2-아미노페닐티오)-3-(4-메톡시페닐)-프로피온산 또는 그의 금속염과 L-리진 또는 그의 산염과의 반응을 가열하에 용매중에서 수행하는 방법.The reaction according to claim 2, wherein the reaction of d1-threo-2-hydroxy-3- (2-aminophenylthio) -3- (4-methoxyphenyl) -propionic acid or a metal salt thereof with L-lysine or an acid salt thereof is carried out. Process carried out in solvent under heating.제2항에 있어서, 식(Ⅱ)의 d1-트레오-2-히드록시-3-(2-아미노페닐티오)-3-(4-메톡시페닐)-프로피온산의 나트륨염고 같은 금속염을 L-리진의 염산염과 같은 산염과 반응시키는 방법.The metal salt as claimed in claim 2, wherein the metal salt such as sodium salt of d1-threo-2-hydroxy-3- (2-aminophenylthio) -3- (4-methoxyphenyl) -propionic acid of formula (II) Reaction with acid salts such as hydrochloride.하기식(Ⅰ)의 d-트레오-2-히드록시-3-(2-아미노페닐티오)-3-(4-메독시페닐)-프로피온산과 L-리진과의 염 수용액에 무기산을 가하여 용액의 pH를 약 2.5 내지 약 3.5로 조절함으로써 수용액으로부터 d-트레오-2-히드록시-3-(2-아미노페닐티오)-3-(4-메녹시페닐)-프로피온산을 침전시킴으을 특징으로 하는, 하기식(Ⅰ)의 d-트레오-2-히드록시-3-(2-아미노페닐티오)-3-(4-메톡시페닐)-프로피온산의 제조방법.Inorganic acid was added to the aqueous solution of the salt of d-threo-2-hydroxy-3- (2-aminophenylthio) -3- (4-methoxyphenyl) -propionic acid and L-lysine of formula (I) characterized by precipitating d-threo-2-hydroxy-3- (2-aminophenylthio) -3- (4-menoxyphenyl) -propionic acid from an aqueous solution by adjusting the pH to about 2.5 to about 3.5 A process for producing d-threo-2-hydroxy-3- (2-aminophenylthio) -3- (4-methoxyphenyl) -propionic acid of formula (I).※참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is to be disclosed based on the initial application.
KR870014715A1987-12-221987-12-22
Optically active carboxylic acid derivative L-lysine salt and preparation method thereof
KR890009860A
(en)
2 ', 4'-difluoro-4-hydroxy- (1,1'-diphenyl) -3-carboxylic acid derivatives of IV-acetylcysteine and S-carboxymethylcysteine with anti-inflammatory action and mucolytic action Manufacturing Method