KR890005513A - 측유동 크로마토그래피 결합분석장치 - Google Patents

측유동 크로마토그래피 결합분석장치 Download PDF

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KR890005513A
KR890005513A KR1019880011633A KR880011633A KR890005513A KR 890005513 A KR890005513 A KR 890005513A KR 1019880011633 A KR1019880011633 A KR 1019880011633A KR 880011633 A KR880011633 A KR 880011633A KR 890005513 A KR890005513 A KR 890005513A
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sample
reaction site
immobilized
reaction
specific binding
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KR1019880011633A
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고던 줄리안
스튜어트 그레델 퓨 찰스
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조셉 엠.버니크
애보트 래보러토리스
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Application filed by 조셉 엠.버니크, 애보트 래보러토리스 filed Critical 조셉 엠.버니크
Publication of KR890005513A publication Critical patent/KR890005513A/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

내용 없음

Description

측유동 크로마토그래피 결합분석장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명에 따른 장치의 투시도이다.
제2도는 제1도에 도시된 장치의 상면도이다. 제3도는 제2도에 도시된 장치의 3-3선을 자른 단면도이다.

Claims (10)

  1. 분석물질 및 표지된 특이적 결합물질로 이루어진 그룹중의 한일원과 결합할 수 있는 고정화된 시약이 존재하는 반응 부위를 포함하면서, 모세관력 및 하나 또는 그 이상의 반응성 샘플 성분 및 비-고정화된 시약에 대한 므로마토그래피 용매 수송력을 갖는 크로마토그래피 매질, 크로마토그래피 매질에 인접하여 위치하고 반응 부위로부터 상향분지된 샘플 투여수단, 및 반응 부위로부터 하향분지된 액체 흡착 수단을 포함함을 특징으로하는, 특이적 결합반응 하나 이상을 이용한 샘플중의 분석 물질의 존재 여부 및 양을 측정하기 위한 시험장치.
  2. 제1항에 있어서, 액체 흡착수단이 크로마토그래피매질인 시험장치.
  3. 제1항에 있어서, 반응 부위로부터 하향분지된 액체 흡착 수단이 크로마토그래피 매질에 인접하여 위치 하는 시험장치.
  4. 제1항에 있어서, 시그날 발생 기질/보조 인자 그룹중의 한일원을 반응부위에 고정화시키는 시험장치.
  5. 제4항에 있어서, 니트로블루 테트라졸륨을 반응부위에 고정화시키는 시험장치.
  6. 분석 물질 및 표지된 특이적 결합물질로 이루어진 그룹중의 한일원과 결합할 수 있는 고정화된 시약이 존재하는 반응부위를 포함하면서, 모세관력 및 하나 또는 그 이상의 비-고정화된 시약 및 반응성 샘플성분에 대한 크로마토그래피 용매 소송력을 갖는 크로마토그래피 매질, 크로마토그래피 물질에 인접하여 위치하고 반응부위로부터 상향 분지된 샘플투여 수단, 및 반응부위로서 하향 분지된 액체 흡착 수단을 포함하는 장치를 이용하여, (a) 일정 용량의 샘플을 샘플 투여수단에 적용시켜 샘플을 크로마토그래피 매질을 따라 반응부위를 통과하여 샘플 흡착수단에 수송하고, (b) 표지된 특이적 결합 물질을 반응부위에 접촉시키고, (c) 반응부위에서 고정화된 표지된 특이적 결합 물질의 존재 여부 또는 양을 샘플중의 기질의 존재여부 또는 양의 지시로서 측정함을 특징으로하여, 샘플중의 분석 물질의 존재여부 또는 양을 측정하는 방법.
  7. 제6항에 있어서, 결합되지 않은 샘플 물질 및 결합되지 않은 특이적 결합물질을 반응 영역으로부터 세척 단계를 통해 제거시키는 방법.
  8. 제6항에 있어서, 액체 흡착 수단이 크로마토그래피 물질에 인접하여 위치하고 반응 부위로부터 하향분지되어 위치하는 방법.
  9. 제6항에 있어서, 반응 부위가 시그날 발생 기질/보조 인자 그룹중의 고정화된 일원을 포함하며, 시그날 발생 기질/보조 인자 그룹중의 하나 또는 그 이상의 추가 일원을 반응 부위에 접촉시켜 시그날 발생반응을 개시하는 단계(C')를 추가로 포함하는 방법.
  10. 제9항에 있어서, 니트로블루 테트라졸을 반응부위에 고정화시키고 브로모클로로인돌릴포스페이트를 가하여 시그날 발생반응을 개시하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880011633A 1987-09-11 1988-09-09 측유동 크로마토그래피 결합분석장치 KR890005513A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9580187A 1987-09-11 1987-09-11
US07/095,801 1987-09-11

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KR890005513A true KR890005513A (ko) 1989-05-15

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KR1019880011633A KR890005513A (ko) 1987-09-11 1988-09-09 측유동 크로마토그래피 결합분석장치

Country Status (9)

Country Link
EP (1) EP0306772B1 (ko)
JP (1) JPH0627738B2 (ko)
KR (1) KR890005513A (ko)
AT (1) ATE86746T1 (ko)
AU (1) AU619480B2 (ko)
CA (1) CA1336577C (ko)
DE (1) DE3879048T2 (ko)
ES (1) ES2039533T3 (ko)
GR (1) GR3007381T3 (ko)

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Also Published As

Publication number Publication date
AU619480B2 (en) 1992-01-30
DE3879048T2 (de) 1993-09-02
DE3879048D1 (de) 1993-04-15
JPH01113662A (ja) 1989-05-02
ATE86746T1 (de) 1993-03-15
AU2175388A (en) 1989-03-16
JPH0627738B2 (ja) 1994-04-13
GR3007381T3 (ko) 1993-07-30
CA1336577C (en) 1995-08-08
EP0306772A1 (en) 1989-03-15
ES2039533T3 (es) 1993-10-01
EP0306772B1 (en) 1993-03-10

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