KR880003632A - Specific antibody-containing material from egg, manufacturing method and use thereof - Google Patents

Specific antibody-containing material from egg, manufacturing method and use thereof Download PDF

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KR880003632A
KR880003632A KR870000607A KR870000607A KR880003632A KR 880003632 A KR880003632 A KR 880003632A KR 870000607 A KR870000607 A KR 870000607A KR 870000607 A KR870000607 A KR 870000607A KR 880003632 A KR880003632 A KR 880003632A
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antigen
egg
specific antibody
hen
containing material
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KR870000607A
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Korean (ko)
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KR910005409B1 (en
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히데오 도고로
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히데오 도고로
호아베스도 유한회사
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/02—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/861—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgG3, IgG4, IgA, or IgY

Abstract

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Description

계란으로부터의 특이적항체함유재료 및 그 제조방법과 용도Specific antibody-containing material from egg, manufacturing method and use thereof

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제 1 도는 돼지의 장독소대장균(ETEC)의 987P+항원에 대한 면역성을 가진후 암탉의 난황내의 항체적정량의 주변화율을 도시한 그래프.1 is a graph showing the marginalization rate of antibody titer in egg yolk of hens after immunity to 987P + antigen of swine enterococci (ETEC).

제 2 도는 동일한 항원에 대해 면역성을 가진 암탉의 알로부터 회수된 난황분말이 투여 집단의 동물들에게 경구투여되며 반면에 이러한 투여는 대조집단에서는 사용되지 않는, 987P+ETEC에 의한 첼린지(Challenge)후 갓 태어난 돼지새끼들의 체온 변화율을 도시한 그래프.Figure 2 shows that yolk powder recovered from eggs of hens immune to the same antigen is orally administered to animals in the administration population, whereas such administration is post-challenge with 987P + ETEC, which is not used in the control population. Graph showing body temperature change rate of newborn piglets.

제 3 도는 987P+ETEC로 첼린지 접종후 갓태어난 돼지 새끼들의 체중 증가율을 도시한 그래프.3 is a graph showing the weight gain rate of newborn piglets after challenge with 987P + ETEC.

Claims (20)

계란으로부터 특이적 항체-함유재료를 제조하는 방법으로서, 다음과 같은 단계로 구성된 제조방법.A method for producing a specific antibody-containing material from eggs, the method comprising the following steps. 항원에 대해 면역성을 갖게하기 위해 선택된 항원으로 암탉을 접종하여 암탉 몸내에 항원에 대한 특이적 항체를 생성시키는 단계 ; 특이적 항체가 난자내에 생성된후 암탉이 낳은 계란을 모으는 단계 ; 그리고 특이적 항체-함유 재료 즉 암탉이 면역성을 갖게하는데 사용되는 항원에 대해 활성인 특이적 항체를 함유하는 재료로서, 특이적항체를 함유하는 계란의 알전체, 난황 또는 난백의 모든 부분 또는 분설을 회수하는 단계.Inoculating a hen with a selected antigen to immunize the antigen to produce a specific antibody to the antigen in the hen body; Collecting eggs laid by the hen after the specific antibody is produced in the egg; And a specific antibody-containing material, i.e. a material containing a specific antibody active against an antigen used to immunize a hen, wherein all parts or fragments of the egg whole, egg yolk or egg white of the egg containing the specific antibody are removed. Recovering. 청구범위 1항에 있어서, 암탉은 물-오일 에멀젼 보조액과 함께 항원으로 접종되는 것을 특징으로 하는 제조방법.The method of claim 1, wherein the hen is inoculated with the antigen together with the water-oil emulsion aid. 청구범위 1 또는 2항에 있어서, 계란의 알전체, 난황 또는 난백의 모든 부분은 분별화 과정을 거치지않고 특이적 항체-함유 재료로서 회수되는 것을 특징으로 하는 제조방법.The method according to claim 1 or 2, wherein all parts of the egg whole, egg yolk or egg white of the egg are recovered as a specific antibody-containing material without undergoing fractionation. 청구범위 3항에 있어서, 특이적 항체-함유재료는 계란의 알전체, 난황 또는 난백의 모든 부분을 교반시켜 에멀젼으로 만들고 이 에멀젼을 건조시켜 분말로 형성시킴으로써 분말의 형태로 회수되는 것을 특징으로 하는 제조방법.The method according to claim 3, characterized in that the specific antibody-containing material is recovered in the form of a powder by stirring all parts of the egg whole, egg yolk or egg white to form an emulsion and drying the emulsion to form a powder. Manufacturing method. 청구범위 1 또는 2항에 있어서, 특이적 항체를 함유하는 계란의 알전체 난황, 또는 난백의 분설은 특이적 항체-함유재료로서 회수되는 것을 특징으로 하는 제조방법.The method according to claim 1 or 2, characterized in that whole egg yolk, or egg white separation of eggs containing a specific antibody, is recovered as a specific antibody-containing material. 청구범위 1항 내지 5항에 있어서, 항원은 꽃가루 박테리아, 바이러스, 곰팡이, 알레르겐, 병든동물로부터 추출한 혈액, 정자 및 톡신으로 구성된 군으로부터 선택되는 것을 특징으로 하는 제조방법.The method of claim 1, wherein the antigen is selected from the group consisting of pollen bacteria, viruses, fungi, allergens, blood extracted from diseased animals, sperm and toxins. 청구범위 1 내지 6항중 어느 한 항에 있어서, 항원은 동물의 장전염병을 유발시키는 대장균 박테리안인 것을 특징으로 하는 제조방법.The method according to any one of claims 1 to 6, wherein the antigen is Escherichia coli bacterium causing an enterocolitis of an animal. 청구범위 1 내지 7항중 어느 한 항에 있어서, 항원은 불활성 항원, 약독성항원, 및 서브유니트항원으로부터 선택되는 것을 특징으로 하는 제조방법.8. The method of claim 1, wherein the antigen is selected from inactive antigens, weakly toxic antigens, and subunit antigens. 청구범위 1 내지 8항중 어느 한 항의 제조방법으로 제조되는 특이적항체-함유재료.A specific antibody-containing material prepared by the method of any one of claims 1 to 8. 특이적 전이인자-류 성분을 함유하는 재료의 제조방법으로서 다음과 같은 단계로 구성된 제조방법.A method for producing a material containing a specific transfer factor-like component, comprising the following steps. 항원에 대해 면역성을 갖게하기위해 선택된 항원으로 암탉에 접종하여 암탉몸내에 항원에 대한 특이적 항체를 생성시키는 단계 ; 특이적항체가 난자내에 생성된후 암탉이 낳은 알을 모으는 단계 ; 특이적 항체를 함유하는 계란의 알전체, 난황 또는 난백을 회수하는 단계 ; 그리고 최대한 분자량 10,000의 회수된 알전체, 난황, 또는 난백의 분설 즉, 암탉이 면역성을 갖는데 사용되는 항원에 대해 특이적인 전이인자-류성분을 함유하는 재료인 상기 분설을 분리해내는 단계.Inoculating the hen with an antigen selected for immunity to the antigen to produce a specific antibody to the antigen in the hen body; Collecting the eggs laid by the hen after the specific antibody is produced in the egg; Recovering the egg whole, egg yolk or egg white of an egg containing a specific antibody; And separating the recovered whole egg, egg yolk, or egg white with a molecular weight of 10,000, i.e., the material containing a transfer factor-like component specific for the antigen that the hen is used to immunize. 청구범위 10항에 있어서, 분설의 분리는 희석시키거나 또는 희석시키지 않고 알전체, 난황 또는 난백을 교반시켜 에멀젼을 만들고, 이 에멀젼을 산으로 처리한 다음 중화시키거나 또는 에멀젼을 유기용매로 처리하고, 원심분리에 의해 침전된 고형물을 제거시키고, 최대한 분자량 10,000인 분설을 분리해내기 위해 상등액을 한외여과시켜 특이적 전이인자-류성분을 함유한 재료로서 회수함으로써 수행되는 것을 특징으로 하는 제조방법.The method according to claim 10, wherein the separation of the separation is performed with or without dilution of the whole, egg yolk or egg white to form an emulsion, which is treated with an acid and then neutralized or the emulsion is treated with an organic solvent. And removing the solid precipitated by centrifugation and ultrafiltration the supernatant to separate the separation of molecular weight 10,000 as much as possible, and recovering it as a material containing a specific transfer factor-like component. 청구범위 10 또는 11항에 있어서, 암탉은 물-오일 에멀젼 보조액과 함께 항원으로 접종되는 것을 특징으로 하는 제조방법.Method according to claim 10 or 11, characterized in that the hen is inoculated with the antigen together with the water-oil emulsion aid. 청구범위 10 내지 12항중 어느 한 항에 있어서, 항원은 꽃가루, 박테리아 바이러스, 곰팡이, 알레르겐, 병든 동물로부터 추출한 혈액, 정자 및 톡신으로 구성된 군으로부터 선택되는 것을 특징으로 하는 제조방법.The method of claim 10, wherein the antigen is selected from the group consisting of pollen, bacterial virus, fungus, allergens, blood extracted from sick animals, sperm and toxin. 청구범위 10 내지 13항중 어느 한 항에 있어서, 항원은 불활성 항원, 약독성항원, 및 서브유니트 항원으로부터 선택되는 것을 특징으로 하는 제조방법.The method of any one of claims 10-13, wherein the antigen is selected from inactive antigens, weakly toxic antigens, and subunit antigens. 청구범위 10 내지 14항중 어느 한 항의 제조방법으로 제조되는 특이적 전이인자-류 성분을 함유하는 재료.A material containing a specific transition factor-like component prepared by the method of any one of claims 10-14. 청구범위 1 내지 9항중 어느 한 항의 제조방법으로 제조되는 특이적항체-함유재료로 구성되는, 동물들의 사료에 사용되는 첨가제.An additive for use in animal feed comprising a specific antibody-containing material prepared by the method of any one of claims 1 to 9. 청구범위 10 내지 14항중 어느 한 항의 제조방법으로 제조되는 특이적 전이인자-류 성분을 함유하는 재료로 구성되는, 동물들의 사료에 사용되는 첨가제.An additive for use in animal feed comprising a material containing a specific transfer factor-like component prepared by the method of any one of claims 10-14. 병원균 항원이 암탉이 면역성을 갖게하는데에 사용되는 청구범위 1 내지 9항중 어느 한 항의 제조방법으로 제조되는 특이적 항체-함유재료를 동물에 경구로 투여하는 것을 특징으로 하는 병원균 항원에 의해 유발되는 장전염병으로부터 동물을 보호하는 방법.Pathogens induced by a pathogen antigen characterized by orally administering to the animal a specific antibody-containing material prepared by the method of any one of claims 1 to 9 in which the pathogen antigen is used to immunize the hen. How to protect animals from infectious diseases. 대장균 박테리아 암탉이 면역성을 갖게하는 항원으로서 사용되는 청구범위 1 내지 9항중 어느한 항의 제조방법으로 제조되는 특이적 항체-함유재료를 동물에 경구로 투여하는 것을 특징으로 하는 대장균 박테리아에 의해 유발되는 동물의 장전염병을 예방 또는 치료하는 방법.Animals induced by E. coli bacteria characterized by orally administering to the animal a specific antibody-containing material prepared by the method of any one of claims 1 to 9 used as an antigen for immunizing E. coli bacterial hens To prevent or treat intestinal infectious diseases in children. 청구범위 19항에 있어서, 암탉이 면역성을 갖게하는데에 사용되는 항원이 장독소 대장균으로부터 얻어지는 것을 특징으로 하는 동물의 장전염병을 예방 또는 치료하는 방법.20. The method of claim 19, wherein the antigen used to immunize the hen is obtained from enterotoxin Escherichia coli. ※ 참고사항 : 최초출원 내용에 분해한 커버의 투시도.※ Note: Perspective view of cover disassembled in original application.
KR1019870000607A 1985-11-25 1987-01-26 Process for preparing specific antibody containing substance from eggs KR910005409B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP26410885 1985-11-25
JP86-218859 1986-09-17
JP61218859A JPH0753669B2 (en) 1985-11-25 1986-09-17 Material containing specific antibody from hen's egg, production method and use thereof
JP218859 1986-09-17

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KR880003632A true KR880003632A (en) 1988-05-28
KR910005409B1 KR910005409B1 (en) 1991-07-29

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Publication number Priority date Publication date Assignee Title
KR100406870B1 (en) * 2001-05-25 2003-11-21 주식회사 두산 Process for purifying water soluble components from egg yolk using precipitation and the use of precipitated by-product
KR20030012563A (en) * 2001-08-01 2003-02-12 주식회사 단바이오텍 Feed compound for substituting antibiotic

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JPH0753669B2 (en) 1995-06-07
KR910005409B1 (en) 1991-07-29

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