KR880002844A - 펜옥사지논, 이의 제조방법 및 용도 - Google Patents

펜옥사지논, 이의 제조방법 및 용도 Download PDF

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Publication number
KR880002844A
KR880002844A KR870009376A KR870009376A KR880002844A KR 880002844 A KR880002844 A KR 880002844A KR 870009376 A KR870009376 A KR 870009376A KR 870009376 A KR870009376 A KR 870009376A KR 880002844 A KR880002844 A KR 880002844A
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South Korea
Prior art keywords
hydrogen
dsm
compound
hydroxyl
compound according
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KR870009376A
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English (en)
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제엑 악첼
브라이딩-막 사비네
그라블러이 주자네
보엘스코브 하르트무트
자이베르트 게르하르트
Original Assignee
하인리히 벡커, 베른하르트 벡
훽스트 아크티엔게젤샤프트
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Application filed by 하인리히 벡커, 베른하르트 벡, 훽스트 아크티엔게젤샤프트 filed Critical 하인리히 벡커, 베른하르트 벡
Publication of KR880002844A publication Critical patent/KR880002844A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

펜옥사지논, 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 일반식(Ⅰ)의 화합물.
    상기식에서,
    R1은 하이드록실 또는(C1-C5)-알콜시 또는 아미노이고, R2는 수소 또는 일반식(여기서, R4는 수소 또는(C1-C5)-아실이고 R5는 하이드록실 또는(C1-C5)의 그룹이며, R3는 수소 또는 (C1-C5)-아실이다.
  2. a) 스트랩토마이세스 종(streptomyces spec.) DSM 3813을 1a) R1은 하이드록실이고 R2는
    이며 R3는 수소이거나, 1b) R1은 하이드록실이고 R2는 수소이며 R3는 아세틸이거나, 1c) R1은 아미노이고 R2및 R3는 수소인 일반식(Ⅰ)의 화합물이 영양배지에 축적될 때까지 영양배지상에서 배양하고, 경우에 따라 b) 언급된 화합물을 분리하고 유도체를 형성시킴을 특징으로 하여, 제1항에 따른 일반식(Ⅰ)의 화합물을 제조하는 방법.
  3. 제2항에 있어서, 스트랩토마이세스 종 DSM 3813을 대두가루 및 만니톨을 함유하는 영양용액 중에서 배양하는 방법.
  4. 제2항 또는 3항에 있어서, 스트랩토마이세스 종 DSM 3813을 18 내지 35℃에서 배양하는 방법.
  5. 제2항 내지 4항중 어느 한 항에 있어서, 스트랩토마이세스 종 DSM 3813을 pH5 내지 8.5에서 배양하는 방법.
  6. 제2항 내지 5항중 어느 한 항에 있어서, 발효에 의해 제조된 화합물로부터 유도체를 화학적으로 형성시키는 방법.
  7. 의약품 제조 또는 진단을 위한 제1항에 따른 화학물의 용도.
  8. 진균, 원생동물 및 바이러스성 감염의 치료를 위한 의약품 제조 및 구충제 제조 및 리폭시게나제 억제제로서의 제1항에 따른 화합물의 용도.
  9. 진균, 바이러스, 원생동물 및 장내기생충에 대한 약제로서의 제1항에 따른 화합물의 용도.
  10. 제1항에 따른 화합물 유효량 및 약제학적으로 허용되는 담체를 함유하는 진균, 원생동물, 바이러스 및 구충 감염의 치료를 위한 약제학적 조성물.
  11. 제1항에 따른 화합물을 생성하는 스트랩토-마이세스 종 DSM 3813 또는 이의 변종 또는 돌연변이체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870009376A 1986-08-27 1987-08-27 펜옥사지논, 이의 제조방법 및 용도 KR880002844A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3629062.9 1986-08-27
DE3629062 1986-08-27

Publications (1)

Publication Number Publication Date
KR880002844A true KR880002844A (ko) 1988-05-11

Family

ID=6308253

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870009376A KR880002844A (ko) 1986-08-27 1987-08-27 펜옥사지논, 이의 제조방법 및 용도

Country Status (14)

Country Link
US (1) US4861775A (ko)
EP (1) EP0260486B1 (ko)
JP (1) JPS6371190A (ko)
KR (1) KR880002844A (ko)
AT (1) ATE60326T1 (ko)
AU (1) AU611642B2 (ko)
DE (1) DE3767621D1 (ko)
DK (1) DK446087A (ko)
ES (1) ES2031860T3 (ko)
GR (1) GR3001560T3 (ko)
HU (1) HU201354B (ko)
IL (1) IL83646A0 (ko)
IN (1) IN164557B (ko)
ZA (1) ZA876353B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03161441A (ja) * 1989-11-20 1991-07-11 Senjiyu Seiyaku Kk メイラード反応阻害剤
CN101132796A (zh) * 2005-02-17 2008-02-27 独立行政法人科学技术振兴机构 含有吩嗪化合物作为活性成分的药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4667032A (en) * 1983-01-21 1987-05-19 Merck Frosst Canada, Inc. Phenothiazone derivatives and analogs

Also Published As

Publication number Publication date
DE3767621D1 (de) 1991-02-28
ATE60326T1 (de) 1991-02-15
HU201354B (en) 1990-10-28
ES2031860T3 (es) 1993-01-01
EP0260486A1 (de) 1988-03-23
JPS6371190A (ja) 1988-03-31
US4861775A (en) 1989-08-29
HUT44624A (en) 1988-03-28
IL83646A0 (en) 1988-01-31
IN164557B (ko) 1989-04-08
DK446087A (da) 1988-02-28
AU7744187A (en) 1988-03-31
EP0260486B1 (de) 1991-01-23
AU611642B2 (en) 1991-06-20
ZA876353B (en) 1988-03-01
DK446087D0 (da) 1987-08-26
GR3001560T3 (en) 1992-11-23

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